Page last updated: 2024-12-06

trimethylsilylisothiocyanate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Trimethylsilylisothiocyanate (TMSCNS) is a versatile reagent in organic synthesis, particularly for the introduction of isothiocyanate (-NCS) functionalities. It is often used in the preparation of isothiocyanates from various starting materials, such as amines, alcohols, and carboxylic acids. The reagent's reactivity stems from the electrophilic nature of the isothiocyanate group, which readily reacts with nucleophiles. TMSCNS has been employed in the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and natural products. Research into TMSCNS focuses on its application in various synthetic transformations, such as the formation of thioureas, isothiocyanates, and heterocyclic compounds. The compound's ability to introduce the isothiocyanate group with high efficiency and selectivity makes it a valuable tool for organic chemists.'

Cross-References

ID SourceID
PubMed CID75297
SCHEMBL ID837256
MeSH IDM0154556

Synonyms (30)

Synonym
2290-65-5
silane, isothiocyanatotrimethyl-
trimethylsilyl isothiocyanate
(trimethylsilyl)isothiocyanate, 99%
isothiocyanato(trimethyl)silane
einecs 218-929-7
isothiocyanatotrimethylsilane
trimethylsilylisothiocyanate
(trimethylsilyl)isothiocyanate
SCHEMBL837256
tmsisothiocyanate
tms-isothiocyanate
trimethylsilyl isothio-cyanate
trimethylsilyl-isothiocyanate
DTXSID4062307
isothiocyanato(trimethyl)silane #
AKOS028108504
mfcd00004797
J-014895
FT-0729941
FS-5342
trimethylsilylisothicyanate
trimethylsilyl isothicyanate
CAA29065
?trimethylsilyl isothiocyanate
F87234
EN300-78444
SY036225
JK38S9F7MN
trimethylisothiocyanatosilane
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]