trimethylolpropane phosphite profile

Trimethylolpropane phosphite (TMPP) is an organophosphorus compound used as a stabilizer in various applications. It is synthesized by reacting trimethylolpropane with phosphorus trichloride. TMPP acts as an antioxidant, preventing oxidation and degradation of materials. Its effectiveness is attributed to its ability to scavenge free radicals. TMPP is widely studied for its potential applications in various industries, including plastics, polymers, and lubricants. It is particularly important as a stabilizer in polyvinyl chloride (PVC) to improve its long-term performance and prevent discoloration. Research focuses on understanding the mechanism of its stabilization and exploring new applications for TMPP in advanced materials.'

Cross-References

ID Source	ID
PubMed CID	13210
SCHEMBL ID	267114
MeSH ID	M0069450

Synonyms (49)

Synonym
1nd7080zyd ,
unii-1nd7080zyd
4-aethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octan
4-ethyl-2,7-trioxa-1-phosphabicyclo[2.2.2]octane
4-aethyl-1-phospha-2,7-trioxabicyclo(2.2.2)octan
nsc-127561
trimethylolpropane phosphite
trimethylolpropane cyclic phosphite (1:1)
1, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphite (1:1)
4-ethyl-1-phospha-2,7-trioxabicyclo[2.2.2]octane
2,7-trioxa-1-phosphabicyclo[2.2.2]octane, 4-ethyl-
824-11-3
nsc127561
1,1-trishydroxymethylpropane bicyclic phosphite
wln: t66 a b ao eopotj c2
4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane
1,1,1-trishydroxymethylpropane bicyclic phosphite
4-aethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octan [german]
einecs 212-523-3
1,3-propanediol, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphite (1:1)
hsdb 6409
nsc 127561
4-ethyl-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane
1,3-propanediol, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphite
2-(hydroxymethyl)-2-ethyl-1,3-propanediol, cyclic phosphite (1:1)
brn 0906923
2,6,7-trioxa-1-phosphabicyclo(2.2.2)octane, 4-ethyl-
4-ethyl-2,6,7-trioxa-1-phosphabicyclo(2.2.2)octane
inchi=1/c6h11o3p/c1-2-6-3-7-10(8-4-6)9-5-6/h2-5h2,1h
T0816
4-ethyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane
4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octan
AKOS006230569
etpb
FT-0626263
SCHEMBL267114
trimethylolpropane phosphite [hsdb]
2-ethyl-2-hydroxymethyl-1,3-propanediol cyclic phosphite
1-ethyl-3,5,8-trioxa-4-phospha(2.2.2)bicyclooctane
ethriol phosphite
QRUSNTDXJQBKBI-UHFFFAOYSA-N
2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane, 4-ethyl-
mfcd00152500
triimethylolpropane phosphite
1,1,1-trimethylolpropane phosphite
ethyl bicyclic phosphite
DTXSID10871809
Q7842218
D92401

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (28.57)	18.7374
1990's	4 (57.14)	18.2507
2000's	1 (14.29)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
molsidomine Molsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.. molsidomine : A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.	1.99	1	ethyl ester; morpholines; oxadiazole; zwitterion	antioxidant; apoptosis inhibitor; cardioprotective agent; nitric oxide donor; vasodilator agent
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.95	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
linsidomine linsidomine: RN given refers to parent cpd; structure	1.99	1	morpholines
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	1.99	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.04	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
trimethylolpropane [no description available]	1.99	1	primary alcohol
hematoporphyrin Hematoporphyrins: Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.. hematoporphyrin : A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.	1.99	1
phosphites Phosphites: Inorganic salts or organic esters of phosphorous acid that contain the (3-)PO3 radical. (From Grant & Hackh's Chemical Dictionary, 5th ed). phosphite(3-) : A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid.	3.37	7	phosphite ion; trivalent inorganic anion
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	1.99	1	cysteinium	fundamental metabolite

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.41	2
Absence Seizure [description not available]	2.37	2
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	2.37	2
Organophosphorus Poisoning [description not available]	1.95	1
Organophosphate Poisoning Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.	1.95	1

trimethylolpropane phosphite

Cross-References

Synonyms (49)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.32

Study Types

trimethylolpropane phosphite

Cross-References

Synonyms (49)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.32

Study Types

Related Drugs (9)

Related Conditions (5)