trimethyl phosphite profile

Trimethyl phosphite, also known as trimethyl triphosphite, is a colorless liquid with a pungent odor. It is a common reagent in organic chemistry, particularly in the synthesis of phosphines and phosphites. It is synthesized by the reaction of phosphorus trichloride (PCl3) with methanol (CH3OH) in the presence of a base, such as triethylamine. Trimethyl phosphite is a versatile compound, used in the synthesis of various pharmaceuticals, pesticides, and other fine chemicals. It acts as a reducing agent, a ligand, and a catalyst in various organic reactions. Its reactivity stems from its ability to donate electrons from its phosphorus atom. Research on trimethyl phosphite focuses on its applications in organic synthesis, catalysis, and its potential in new chemical processes. Its importance lies in its ability to provide efficient and selective pathways for the synthesis of complex molecules.'

trimethyl phosphite: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

trimethyl phosphite : An organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	8472
CHEMBL ID	3186364
CHEBI ID	183313
SCHEMBL ID	58775
MeSH ID	M0054404

Synonym
trimethylphosphit
trimethoxyphosphane
phosphorous acid trimethyl ester
p(ome)3
CHEBI:183313
tmphite
trimethyl ester of phosphorous acid
121-45-9
trimethyl phosphite
methyl phosphite ((meo)3p)
trimethoxyphosphine
nsc-6513
phosphorous acid, trimethyl ester
nsc6513
wln: 1opo1 & o1
methyl phosphite
einecs 204-471-5
un2329
nsc 6513
ai3-60394
fosforyn trojmetylowy [czech]
trimethylphosphite
trimethylfosfit [czech]
trimethoxyfosfin [czech]
hsdb 1007
inchi=1/c3h9o3p/c1-4-7(5-2)6-3/h1-3h
phosphorous acid,trimethyl ester
trimethyl phosphite, >=99.999% trace metals basis
trimethyl phosphite, 97%
trimethyl phosphite, >=99%
FT-0655759
AKOS000121918
dtxsid4026979 ,
cas-121-45-9
tox21_200440
NCGC00257994-01
dtxcid106979
T0488
FT-0675632
ec 204-471-5
26q0321zdg ,
trimethyl phosphite [un2329] [flammable liquid]
unii-26q0321zdg
trimethoxyfosfin
fosforyn trojmetylowy
trimethylfosfit
BP-21379
SCHEMBL58775
trimethyl-phosphite
p(och3)3
trimethyl phosphite [hsdb]
un 2329
CHEMBL3186364
trimethyl phosphite, >=97%
mfcd00008350
Q153418
trimethyl phosphite (tmpi)

Excerpt	Reference	Relevance
"Trimethyl phosphite (TMP) is an organophosphorus alkylating agent used primarily in the synthesis of organophosphate compounds. "	( Teratological evaluation of trimethyl phosphite in the rat. Craig, PH; Gallo, MA; Mehlman, MA, 1984)	2

Excerpt	Reference	Relevance
"The studies on toxic properties of trimethyl and triethyl phosphities involved: determination of acute general toxic effect on white rats following intragastric and intraperitoneal administration of these compounds, based on DL50 test, determination of damaging effect direction, by histopathological examination of animals' internal organs, determination of intensity of primarily irritating action on the skin, eye and conjunctiva, as well as sensitizing effect on guinea-pigs."	( [Acute toxic effects of trimethyl and triethyl phosphites]. Czajkowska, T; Graczyk, J; Krysiak, B; Stetkiewicz, J, 1978)	0.26

Role	Description
alkylating agent	Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
organophosphorus compound	An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	17.7559	0.0015	30.6073	15,848.9004	AID1224849
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (25.00)	18.7374
1990's	2 (16.67)	18.2507
2000's	3 (25.00)	29.6817
2010's	3 (25.00)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.11	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.46	2	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
hydrochloric acid Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.. hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.	2.07	1	chlorine molecular entity; gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	1.96	1	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	7.05	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
ethylene oxide Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794). oxirane : A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.	2.01	1	gas molecular entity; oxacycle; saturated organic heteromonocyclic parent	allergen; mouse metabolite; mutagen
dimethyl sulfate dimethyl sulfate: RN given refers to unlabeled cpd; structure. dimethyl sulfate : The dimethyl ester of sulfuric acid.	2	1	alkyl sulfate	alkylating agent; immunosuppressive agent
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	2.11	1	chromium group element atom	micronutrient
phosphine phosphane : The simplest phosphine, consisting of a single phosphorus atom with three hydrogens attached.. phosphine : Phosphane (PH3) and compounds derived from it by substituting one, two or three hydrogen atoms by hydrocarbyl groups: RPH2, R2PH, R3P (R =/= H) are called primary, secondary and tertiary phosphines, respectively. A specific phosphine is preferably named as a substituted phosphane.	2.11	1	mononuclear parent hydride; phosphanes; phosphine	carcinogenic agent; fumigant insecticide
triethyl phosphite triethyl phosphite: RN given refers to parent cpd; structure	1.95	1
alkenes [no description available]	7.01	1
phosphites Phosphites: Inorganic salts or organic esters of phosphorous acid that contain the (3-)PO3 radical. (From Grant & Hackh's Chemical Dictionary, 5th ed). phosphite(3-) : A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid.	3.87	12	phosphite ion; trivalent inorganic anion
carbene carbene: electrically neutral species H2C: and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons; carbene is the name of the parent hydride :CH2 ; hence, the name dichlorocarbene for :CCl2. However, names for acyclic and cyclic hydrocarbons containing one or more divalent carbon atoms are derived from the name of the corresponding all-4-hydrocarbon using the suffix -ylidene; methylene carbene also available. carbene : The electrically neutral species H2C(2.) and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons, which may be spin-paired (singlet state) or spin-non-paired (triplet state).	2.11	1	carbene; methanediyl
molybdenum chloride [no description available]	2.11	1
organophosphonates hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.	2.04	1	divalent inorganic anion; phosphite ion

Condition	Relationship Strength	Studies
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.95	1
Contact Dermatitis [description not available]	1.95	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	1.95	1

trimethyl phosphite

Description

Cross-References

Synonyms (57)

Research Excerpts

Overview

Toxicity

Roles (1)

Drug Classes (1)

Protein Targets (1)

Potency Measurements

Research

Studies (12)

Market Indicators

Research Demand Index: 41.77

Study Types