Page last updated: 2024-12-06

trimethyl citrate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Trimethyl citrate is a colorless, odorless liquid that is soluble in water and organic solvents. It is synthesized by the reaction of citric acid with methanol. Trimethyl citrate is used as a plasticizer, a flavoring agent, and a solvent. It has also been studied for its potential applications in medicine and agriculture. For example, trimethyl citrate has been shown to have anti-inflammatory and antioxidant properties. It has also been investigated for its potential to improve crop yield and protect plants from pests and diseases.'

trimethyl citrate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID74112
CHEMBL ID455514
SCHEMBL ID168730
MeSH IDM0456230

Synonyms (39)

Synonym
1,2,3-propanetricarboxylic acid, 2-hydroxy-, trimethyl ester
trimethyl citrate
1,3-propanetricarboxylic acid, 2-hydroxy-, trimethyl ester
nsc75824
nsc-75824
1587-20-8
citric acid, trimethyl ester
NCIOPEN2_004149
trimethyl citrate, >=98.0%
citric acid trimethyl ester
hddlvzwgopwkfw-uhfffaoysa-
inchi=1/c9h14o7/c1-14-6(10)4-9(13,8(12)16-3)5-7(11)15-2/h13h,4-5h2,1-3h3
1,2,3-trimethyl 2-hydroxypropane-1,2,3-tricarboxylate
trimethyl 2-hydroxypropane-1,2,3-tricarboxylate
CHEMBL455514
c9h14o7
einecs 216-449-2
nsc 75824
unii-2p8176332l
2p8176332l ,
1,2,3-propanetricarboxylic acid, 2-hydroxy-, 1,2,3-trimethyl ester
AKOS015901740
SCHEMBL168730
DTXSID2061804
trimethylcitrate
3-hydroxy-3-methoxycarbonylpentanedioic acid, dimethyl ester
HDDLVZWGOPWKFW-UHFFFAOYSA-N
trimethyl 2-hydroxy-1,2,3-propanetricarboxylate #
trimethyl2-hydroxypropane-1,2,3-tricarboxylate
1,2,3-propanetricarboxylicacid, 2-hydroxy-, 1,2,3-trimethyl ester
mfcd00025889
EN300-749076
J-009525
3-hydroxy-3-methoxycarbonyl-pentanedioic acid dimethyl ester
FT-0726449
AS-12383
Q27255361
W11576
CS-W014165
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1376888Antimicrobial activity against Bacillus cereus DSM 4313 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1376887Antimicrobial activity against Escherichia coli DSM 8579 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1376890Antimicrobial activity against Staphylococcus aureus DSM 25923 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1376875Cytotoxicity against human DeFew cells at 10 to 100 uM by MTT assay
AID1376873Antioxidant activity in human plasma assessed as inhibition of H2O2/Fe2+-induced lipid peroxidation at 10 uM after 30 mins by TBARS assay relative to control
AID398683Hypoglycemic activity in Swiss-Webster mouse assessed as change plasma glucose level at 250 mg/kg, ip after 4 hrs1995Journal of natural products, Aug, Volume: 58, Issue:8
Identification of 3-hydroxy-3-methylglutaric acid (HMG) as a hypoglycemic principle of Spanish moss (Tillandsia usneoides).
AID1376874Cytotoxicity against human A549 cells at 10 to 100 uM by MTT assay
AID1376872Antioxidant activity in human plasma assessed as inhibition of H2O2-induced lipid peroxidation at 10 uM after 30 mins by TBARS assay relative to control
AID1376889Antimicrobial activity against Pseudomonas aeruginosa DSM 50071 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1376886Antimicrobial activity against Bacillus cereus DSM 4384 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.25 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.69 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]