Page last updated: 2024-12-06
trimethyl citrate
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
Trimethyl citrate is a colorless, odorless liquid that is soluble in water and organic solvents. It is synthesized by the reaction of citric acid with methanol. Trimethyl citrate is used as a plasticizer, a flavoring agent, and a solvent. It has also been studied for its potential applications in medicine and agriculture. For example, trimethyl citrate has been shown to have anti-inflammatory and antioxidant properties. It has also been investigated for its potential to improve crop yield and protect plants from pests and diseases.'
trimethyl citrate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 74112 |
| CHEMBL ID | 455514 |
| SCHEMBL ID | 168730 |
| MeSH ID | M0456230 |
Synonyms (39)
| Synonym |
|---|
| 1,2,3-propanetricarboxylic acid, 2-hydroxy-, trimethyl ester |
| trimethyl citrate |
| 1,3-propanetricarboxylic acid, 2-hydroxy-, trimethyl ester |
| nsc75824 |
| nsc-75824 |
| 1587-20-8 |
| citric acid, trimethyl ester |
| NCIOPEN2_004149 |
| trimethyl citrate, >=98.0% |
| citric acid trimethyl ester |
| hddlvzwgopwkfw-uhfffaoysa- |
| inchi=1/c9h14o7/c1-14-6(10)4-9(13,8(12)16-3)5-7(11)15-2/h13h,4-5h2,1-3h3 |
| 1,2,3-trimethyl 2-hydroxypropane-1,2,3-tricarboxylate |
| trimethyl 2-hydroxypropane-1,2,3-tricarboxylate |
| CHEMBL455514 |
| c9h14o7 |
| einecs 216-449-2 |
| nsc 75824 |
| unii-2p8176332l |
| 2p8176332l , |
| 1,2,3-propanetricarboxylic acid, 2-hydroxy-, 1,2,3-trimethyl ester |
| AKOS015901740 |
| SCHEMBL168730 |
| DTXSID2061804 |
| trimethylcitrate |
| 3-hydroxy-3-methoxycarbonylpentanedioic acid, dimethyl ester |
| HDDLVZWGOPWKFW-UHFFFAOYSA-N |
| trimethyl 2-hydroxy-1,2,3-propanetricarboxylate # |
| trimethyl2-hydroxypropane-1,2,3-tricarboxylate |
| 1,2,3-propanetricarboxylicacid, 2-hydroxy-, 1,2,3-trimethyl ester |
| mfcd00025889 |
| EN300-749076 |
| J-009525 |
| 3-hydroxy-3-methoxycarbonyl-pentanedioic acid dimethyl ester |
| FT-0726449 |
| AS-12383 |
| Q27255361 |
| W11576 |
| CS-W014165 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1376888 | Antimicrobial activity against Bacillus cereus DSM 4313 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter) | |||
| AID1376887 | Antimicrobial activity against Escherichia coli DSM 8579 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter) | |||
| AID1376890 | Antimicrobial activity against Staphylococcus aureus DSM 25923 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter) | |||
| AID1376875 | Cytotoxicity against human DeFew cells at 10 to 100 uM by MTT assay | |||
| AID1376873 | Antioxidant activity in human plasma assessed as inhibition of H2O2/Fe2+-induced lipid peroxidation at 10 uM after 30 mins by TBARS assay relative to control | |||
| AID398683 | Hypoglycemic activity in Swiss-Webster mouse assessed as change plasma glucose level at 250 mg/kg, ip after 4 hrs | 1995 | Journal of natural products, Aug, Volume: 58, Issue:8 | Identification of 3-hydroxy-3-methylglutaric acid (HMG) as a hypoglycemic principle of Spanish moss (Tillandsia usneoides). |
| AID1376874 | Cytotoxicity against human A549 cells at 10 to 100 uM by MTT assay | |||
| AID1376872 | Antioxidant activity in human plasma assessed as inhibition of H2O2-induced lipid peroxidation at 10 uM after 30 mins by TBARS assay relative to control | |||
| AID1376889 | Antimicrobial activity against Pseudomonas aeruginosa DSM 50071 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter) | |||
| AID1376886 | Antimicrobial activity against Bacillus cereus DSM 4384 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter) | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 31.25
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (31.25) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||