Trifluoroacetanilide is a white, crystalline solid compound that is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is synthesized by the reaction of trifluoroacetic anhydride with aniline. Trifluoroacetanilide exhibits biological activity, including anti-inflammatory and analgesic properties. Its unique structure and chemical properties make it a valuable building block in drug discovery and development. Researchers study trifluoroacetanilide to understand its potential therapeutic applications and to explore its reactivity and synthetic versatility.'
```
| ID Source | ID |
|---|---|
| PubMed CID | 67881 |
| SCHEMBL ID | 474941 |
| MeSH ID | M0054352 |
| Synonym |
|---|
| HMS1474P07 |
| BB 0258807 |
| acetanilide, 2,2,2-trifluoro- |
| acetamide, 2,2,2-trifluoro-n-phenyl- |
| 2,2-trifluoroacetanilide |
| nsc-9474 |
| acetamide,2,2-trifluoro-n-phenyl- |
| 404-24-0 |
| .alpha.,.alpha.-trifluoroacetanilide |
| nsc9474 |
| acetanilide,2,2-trifluoro- |
| trifluoroacetanilide |
| alpha, alpha, alpha-trifluoroacetanilide |
| 2,2,2-trifluoro-n-phenyl-acetamide |
| CHEMDIV3_000689 |
| NCGC00172620-01 |
| BRD-K56317999-001-01-7 |
| 2,2,2-trifluoro-n-phenylacetamide |
| AKOS001092693 |
| nsc 9474 |
| alpha,alpha,alpha-trifluoroacetanilide |
| 75vuz1674i , |
| einecs 206-965-6 |
| unii-75vuz1674i |
| 2,2,2-trifluoroacetanilide |
| n-trifluoroacetylaniline |
| FT-0680636 |
| F0722-1368 |
| trifluoracetanilide |
| n-trifluoroacetylaminobenzene |
| T3645 |
| 8E-016 |
| SCHEMBL474941 |
| n-phenyl-2,2,2-trifluoroacetamide |
| n-phenyltrifluoroacetamide |
| 2,2,2-trifluoro-n-phenylacetamide # |
| .alpha.,.alpha.,.alpha.-trifluoroacetanilide |
| J-506764 |
| DTXSID30193398 |
| SR-01000400085-1 |
| sr-01000400085 |
| mfcd00196027 |
| Z57056420 |
| SY032147 |
| Q27266409 |
| CS-W015963 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.24) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||