Compounds > trichodermamide a
Page last updated: 2024-11-12

trichodermamide a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

trichodermamide A: from cultures of the marine-derived fungus Trichoderma virens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10982906
CHEMBL ID477717
CHEBI ID188558
MeSH IDM0453205

Synonyms (7)

Synonym
CHEMBL477717
trichodermamide a
(4as,5r,8r,8as)-n-(7,8-dimethoxy-2-oxochromen-3-yl)-4a,5,8-trihydroxy-4,5,8,8a-tetrahydro-1,2-benzoxazine-3-carboxamide
CHEBI:188558
Q63396565
DTXSID40894001
508218-11-9
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
coumarins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID337072Antimicrobial activity against vancomycin-resistant Enterococcus faecium2003Journal of natural products, Mar, Volume: 66, Issue:3
Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.
AID337070Antimicrobial activity against amphoterocin-resistant Candida albicans2003Journal of natural products, Mar, Volume: 66, Issue:3
Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.
AID1478424Cytotoxicity against human HL60 cells2017Journal of natural products, 03-24, Volume: 80, Issue:3
Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues.
AID1478425Cytotoxicity against human A549 cells2017Journal of natural products, 03-24, Volume: 80, Issue:3
Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues.
AID1478427Cytotoxicity against human HeLa cells after 48 hrs by SRB assay2017Journal of natural products, 03-24, Volume: 80, Issue:3
Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues.
AID1478426Cytotoxicity against mouse P388 cells2017Journal of natural products, 03-24, Volume: 80, Issue:3
Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues.
AID337071Antimicrobial activity against methacillin-resistant Staphylococcus aureus2003Journal of natural products, Mar, Volume: 66, Issue:3
Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.
AID337069Cytotoxicity against human HCT116 cells2003Journal of natural products, Mar, Volume: 66, Issue:3
Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinone
benzoquinone : The simplest members of the class of benzoquinones, consisting of cyclohexadiene which is substituted by two oxo groups.. 1,4-benzoquinone : The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.. quinone : Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).		2.11101,4-benzoquinonescofactor;
human xenobiotic metabolite;
mouse metabolite
quinic acid
(-)-quinic acid : The (-)-enantiomer of quinic acid.		2.0310
trichodermamide b
trichodermamide B: from cultures of the marine-derived fungus Trichoderma virens; structure in first source		3.1550
aspergillazine a
aspergillazine A: structure in first source		7.7930
gliovirin
gliovirin: from Gliocladium virens; structure given in first source		2.4620
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.0110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0110
Colorectal Cancer
[description not available]		02.1510
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.1510
Benign Neoplasms
[description not available]		02.2510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.2510