Page last updated: 2024-12-09

tretoquinol hydrochloride anhydrous

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID656634
CHEMBL ID1788290
MeSH IDM0582610

Synonyms (39)

Synonym
l-1-(3,4,5-trimethylbenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
6,7-isoquinolinediol, 1,2,3,4-tetrahydro-1-((3,4,5-trimethoxyphenyl)methyl)-, hydrochloride, (s)-
trimetoquinol (van)
l-1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
tretoquinol l-form hydrochloride
1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, l-
einecs 242-423-5
triquinol
l-trimetoquinol
nsc 288748
6,7-isoquinolinediol, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)-, hydrochloride, (-)-
trimethoquinol (van)
ccris 1913
trikvinol (triquinol) hydrochloride
trimethoquinol
18559-59-6
trimetoquinol-hydrochloride
aql 208
D01978
inolin (tn)
trimetoquinol hydrochloride
CHEMBL1788290
NCGC00182977-01
unii-298sp836n4
298sp836n4 ,
cas-18559-59-6
tox21_113220
dtxcid8028682
dtxsid1048756 ,
tretoquinol l-form hydrochloride [mi]
(-)-1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)isoquinoline-6,7-diol hydrochloride
tretoquinol hydrochloride anhydrous
anhydrous tretoquinol hydrochloride
6,7-isoquinolinediol, 1,2,3,4-tetrahydro-1-((3,4,5-trimethoxyphenyl)methyl)-, hydrochloride (1:1), (1s)-
anhydrous tretoquinol hydrochloride [mart.]
(1s)-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol;hydrochloride
(-)-trimetoquinol; aql 208; bentomex; inolin; nsc 288748
Q27254403
s-(-)-tretoquinol hydrochloride

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency26.83250.000221.22318,912.5098AID743036
estrogen nuclear receptor alphaHomo sapiens (human)Potency10.68220.000229.305416,493.5996AID743069
aryl hydrocarbon receptorHomo sapiens (human)Potency33.49150.000723.06741,258.9301AID743085
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency5.62340.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1146267Agonist activity at beta 2 adrenergic receptor in Sprague-Dawley rat adipocytes assessed as lipolysis after 1 hr1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Synthesis of 1-substituted analogues of trimetoquinol possessing differential and selective beta-adrenergic properties.
AID41015Compound was evaluated for beta-2 adrenergic receptor activity on carbachol-contracted guinea pig tracheal strips1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Syntheses and beta-adrenergic agonist and antiaggregatory properties of N-substituted trimetoquinol analogues.
AID92815Compound was evaluated for the inhibition of U-46,619-induced human platelet aggregation (Antiaggregatory activity)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Syntheses and beta-adrenergic agonist and antiaggregatory properties of N-substituted trimetoquinol analogues.
AID92819Compound was evaluated for the secretion of [14C]- Serotonin (Antisecretory activity)1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Syntheses and beta-adrenergic agonist and antiaggregatory properties of N-substituted trimetoquinol analogues.
AID1146265Agonist activity at beta 2 adrenergic receptor in guinea pig trachea assessed as tracheal relaxation1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Synthesis of 1-substituted analogues of trimetoquinol possessing differential and selective beta-adrenergic properties.
AID39963Compound was evaluated for beta-1 adrenergic receptor activity in spontaneously beating guinea pig right atria.1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Syntheses and beta-adrenergic agonist and antiaggregatory properties of N-substituted trimetoquinol analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]