Compounds > tracheal cytotoxin, bordetella pertussis
Page last updated: 2024-12-08

tracheal cytotoxin, bordetella pertussis

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tracheal cytotoxin, Bordetella pertussis: RN & structure given in first source; a disaccharide-tetrapeptide derivative of the cell wall peptidoglycan layer; attaches to ciliated epithelial cells resulting in their destruction [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID163626
CHEBI ID46763
MeSH IDM0166029

Synonyms (16)

Synonym
2-acetamido-2-deoxy-beta-d-glucopyranose(beta1-4)-2-acetamido-1,6-anhydro-3-o-[(r)-1-carboxyethyl]-2-deoxy-beta-d-glucopyranose-l-alanyl-gamma-d-glutamyl-meso-diaminopimelyl-d-alanine
glcnac(beta1-4)-murnac(1,6-anhydro)-l-ala-gamma-d-glu-meso-a2pm-d-ala
DB04736
94102-64-4
tat-bp
n-[(2r)-2-{[(1r,2s,3r,4r,5r)-4-acetamido-2-(2-acetamido-2-deoxy-beta-d-glucopyranosyloxy)-6,8-dioxabicyclo[3.2.1]oct-3-yl]oxy}propanoyl]-l-alanyl-n-[(1s,5r)-5-amino-5-carboxy-1-{[(1r)-1-carboxyethyl]carbamoyl}pentyl]-d-glutamine
CHEBI:46763
n-(n-acetyl-4-o-(2-(acetylamino)-2-deoxy-beta-d-glucopyranosyl)-1,6-anhydro-beta-muramoyl)-l-alanyl-d-gamma-glutamyl-(6r)-6-carboxy-l-lysyl-d-alanine
tracheal cytotoxin, bordetella pertussis
d-alanine, n-(n-acetyl-4-o-(2-(acetylamino)-2-deoxy-beta-d-glucopyranosyl)-1,6-anhydro-beta-muramoyl)-l-alanyl-d-gamma-glutamyl)-(6r)-6-carboxy-l-lysyl-
DTXSID90276530
118013-66-4
(2r,5s,10r,13s,16r)-16-{[(1r,2s,3r,4r,5r)-4-(acetylamino)-2-{[(2s,3r,4r,5s,6r)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl]oxy}-6,8-dioxabicyclo[3.2.1]oct-3-yl]oxy}-5-[(4r)-4-amino-4-carboxybutyl]-10-carboxy-2,13-dimethyl-4,7,1
Q27095473
(2r,6s)-6-[[(4r)-4-[[(2s)-2-[[(2r)-2-[[(1r,2s,3r,4r,5r)-4-acetamido-2-[(2s,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,8-dioxabicyclo[3.2.1]octan-3-yl]oxy]propanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-2-amino-7-[[(1
PD006438

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The toxic effects of nitric oxide are consistent with spectroscopic evidence of the formation of iron-dinitrosyl-dithiolate complexes in TCT-treated cells."( Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis.
Corbett, JA; Goldman, WE; Heiss, LN; Lancaster, JR, 1994)		0.29

Dosage Studied

ExcerptRelevanceReference
" Although lactyl tetrapeptides are the most toxic of the TCT fragments, producing dose-response curves identical to TCT, the smallest analogues of TCT which are active in our assay are of the form X-gamma-(D)-Glu-meso-A2pm, where X may be an amino acid or a blocking group."( Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis.
Goldman, WE; Luker, KE; Marshall, GR; Tyler, AN, 1995)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-acetyl-beta-D-glycosaminyl glycopeptideA glycopeptide having an N-acetyl-beta-D-glycosaminyl residue at the non-reducing end.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (7)

PathwayProteinsCompounds
Peptidoglycan cytoplasmic synthesis and recycling pathways834
Drosophila signaling pathways1928
Imd pathway244
Formation of the PGN:PGRP-LC/LE receptor 'signalling complex'71
Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE21
Peptidoglycan bound PGRP-LC/LE oligomerises31
Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'31

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (8.70)18.7374
1990's14 (60.87)18.2507
2000's3 (13.04)29.6817
2010's2 (8.70)24.3611
2020's2 (8.70)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.39 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index5.27 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (17.39%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (82.61%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.0210aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		1.9810arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
glycidyl nitrate
glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.		6.68230
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		1.9810amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
diaminopimelic acid
Diaminopimelic Acid: A diamino derivative of heptanedioic acid with amino groups at C-2 and C-6 and the general formula (COOH)CH(NH2)CH2CH2CH2CH(NH2)(COOH).. LL-2,6-diaminopimelic acid : A 2,6-diaminopimelic acid in which both chiral centres have S configuration. It is a component of bacterial cell wall.		2.43202,6-diaminopimelic acid;
amino acid zwitterion		Escherichia coli metabolite
n-formylmethionine leucyl-phenylalanine
N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.. N-formyl-L-methionyl-L-leucyl-L-phenylalanine : A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.		1.9810tripeptide
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Bordetella pertussis Infection, Respiratory
[description not available]		04.4750
Whooping Cough
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.		04.4750