tissue plasminogen activator

Description

thiocitrulline : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	3353976
CHEMBL ID	1608298
SCHEMBL ID	3276661
CHEBI ID	139389
MeSH ID	M0016991

Synonyms (15)

Synonym
EU-0101244
LOPAC0_001244
thiocitrulline ,
NCGC00094485-02
NCGC00094485-01
NCGC00015991-02
CHEBI:139389
n5-(aminothioxomethyl)-l-ornithine
T-173
CCG-205318
NCGC00015991-03
SCHEMBL3276661
CHEMBL1608298
SR-01000075525-1
sr-01000075525

Drug Classes (1)

Class	Description
alpha-amino acid	An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.

Pathways (1)

tissue plasminogen activator is involved in 1 pathway(s), involving a total of 5 unique proteins and 7 unique compounds

Pathway	Proteins	Compounds
protein citrullination	5	7

Protein Targets (6)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Microtubule-associated protein tau	Homo sapiens (human)	Potency	7.0193	AID1460; AID1468
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	2.5119	AID1030
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	8.9125	AID504332
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	12.5893	AID2364; AID2528
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	35.4813	AID588834
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	19.9526	AID488949

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6 ISSN: 1552-454X	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

Research

Studies (31)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	16 (51.61)	18.2507
2000's	12 (38.71)	29.6817
2010's	2 (6.45)	24.3611
2020's	1 (3.23)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (3.13%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	31 (96.88%)	84.16%

Substance	Classes	Roles	Relationship Strength
DL-Canavanine	alpha-amino acid		low
n(g),n(g')-dimethyl-l-arginine	alpha-amino acid		low
cysteine	alpha-amino acid; amino acid zwitterion; polar amino acid; sulfur-containing amino acid	fundamental metabolite	low
alanine	alpha-amino acid; amino acid zwitterion	fundamental metabolite	low
glycine	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical	low
endolysin	alpha-amino acid; diamino acid; polar amino acid	Daphnia magna metabolite	low
racemethionine	alpha-amino acid; amino acid zwitterion; sulfur-containing amino acid	algal metabolite; Daphnia magna metabolite; Escherichia coli metabolite; plant metabolite; Saccharomyces cerevisiae metabolite	low
phenylalanine	alpha-amino acid; aromatic amino acid	Daphnia magna metabolite	low
tryptophan	alpha-amino acid; amino acid zwitterion; aminoalkylindole; aromatic amino acid; polar amino acid	Daphnia magna metabolite	low
(alpha-carboxycyclopropyl)glycine	alpha-amino acid		low
1-aminocyclohexanecarboxylic acid	alpha-amino acid		low
2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid	alpha-amino acid		low
alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate	alpha-amino acid		low
eflornithine	alpha-amino acid; fluoroamino acid	trypanocidal drug	low
mimosine	alpha-amino acid		low
4-carboxyphenylglycine	alpha-amino acid		low
acediasulfone	alpha-amino acid		low
methiin	alpha-amino acid		low
2-amino-5-hydroxyvaleric acid	alpha-amino acid		low
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid	alpha-amino acid; aromatic amino acid; beta-carboline alkaloid	human urinary metabolite; human xenobiotic metabolite; plant metabolite; rat metabolite	low
3,5-dihydroxyphenylglycine	alpha-amino acid		low
alliin	alpha-amino acid		low
laminine	alpha-amino acid		low
homocysteinesulfinic acid	alpha-amino acid		low
spinacine	alpha-amino acid		low
edba	alpha-amino acid		low
ubp296	alpha-amino acid		low
cycloalliin	alpha-amino acid		low
furosine	alpha-amino acid		low
4-hydroxy-4-(indol-3-ylmethyl)glutamic acid	alpha-amino acid		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	1990's	2000's	2010's	post-2020
adenine	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2000	2000	24.0	low	0	1	0	0	0
chlorine	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite	2003	2003	21.0	low	0	0	1	0	0
aminocaproic acid	1	amino acid zwitterion; epsilon-amino acid; omega-amino fatty acid	antifibrinolytic drug; hematologic agent; metabolite	1994	1994	30.0	low	0	1	0	0	0
hydroxylamine	1	hydroxylamines	algal metabolite; bacterial xenobiotic metabolite; EC 1.1.3.13 (alcohol oxidase) inhibitor; EC 4.2.1.22 (cystathionine beta-synthase) inhibitor; EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor; nitric oxide donor; nucleophilic reagent	2005	2005	19.0	low	0	0	1	0	0
niacinamide	1	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor	2000	2000	24.0	low	0	1	0	0	0
urea	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2005	2005	19.0	low	0	0	1	0	0
1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	1	oxadiazoloquinoxaline	EC 4.6.1.2 (guanylate cyclase) inhibitor	2000	2000	24.0	low	0	1	0	0	0
7-nitroindazole	1			2003	2003	21.0	low	0	0	1	0	0
pimagedine	2	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor	1997	1998	26.5	low	0	2	0	0	0
erythrosine	1			2008	2008	16.0	low	0	0	1	0	0
ethacrynic acid	1	aromatic ether; aromatic ketone; dichlorobenzene; monocarboxylic acid	EC 2.5.1.18 (glutathione transferase) inhibitor; ion transport inhibitor; loop diuretic	2008	2008	16.0	low	0	0	1	0	0
mechlorethamine	1	nitrogen mustard; organochlorine compound	alkylating agent	2000	2000	24.0	low	0	1	0	0	0
methenamine	1	polyazaalkane; polycyclic cage; tetramine	antibacterial drug	2000	2000	24.0	low	0	1	0	0	0
etiron	1			1997	1997	27.0	low	0	1	0	0	0
s-methylisothiopseudouronium	1			1997	1997	27.0	low	0	1	0	0	0
trifluoperazine	1	N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines	antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug	1997	1997	27.0	low	0	1	0	0	0
w 7	1			1997	1997	27.0	low	0	1	0	0	0
penicillamine	1	non-proteinogenic alpha-amino acid; penicillamine	antirheumatic drug; chelator; copper chelator; drug allergen	1999	1999	25.0	low	0	1	0	0	0
lysine	2	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	1997	1999	26.0	low	0	2	0	0	0
cyanides	1	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor	2003	2003	21.0	low	0	0	1	0	0
adenosine diphosphate	1	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite	1995	1995	29.0	low	0	1	0	0	0
phenylephrine	1	phenols; phenylethanolamines; secondary amino compound	alpha-adrenergic agonist; cardiotonic drug; mydriatic agent; nasal decongestant; protective agent; sympathomimetic agent; vasoconstrictor agent	1995	1995	29.0	low	0	1	0	0	0
ornithine	2	non-proteinogenic L-alpha-amino acid; ornithine	algal metabolite; hepatoprotective agent; mouse metabolite	1997	1997	27.0	low	0	2	0	0	0
arginine	12	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical	1994	2003	26.3	low	0	10	2	0	0
quinoxalines	1	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene		2000	2000	24.0	low	0	1	0	0	0
pyrrolidonecarboxylic acid	1	5-oxoproline; L-proline derivative; non-proteinogenic L-alpha-amino acid	algal metabolite	2008	2008	16.0	low	0	0	1	0	0
indazoles	1	indazole		2003	2003	21.0	low	0	0	1	0	0
citrulline	29	amino acid zwitterion; citrulline	Daphnia magna metabolite; EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; protective agent; Saccharomyces cerevisiae metabolite	1994	2012	24.2	medium	0	20	8	1	0
thiazolidines	1	thiazolidine		2008	2008	16.0	low	0	0	1	0	0
mustard gas	4	ethyl sulfide; organochlorine compound	alkylating agent; carcinogenic agent; vesicant	1998	2000	24.8	low	0	4	0	0	0
acetylcysteine	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary	2000	2000	24.0	low	0	1	0	0	0
buthionine sulfoximine	1	diastereoisomeric mixture; homocysteines; non-proteinogenic alpha-amino acid; sulfoximide	EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor; ferroptosis inducer	2008	2008	16.0	low	0	0	1	0	0
isothiuronium	1			1997	1997	27.0	low	0	1	0	0	0
ng-nitroarginine methyl ester	13	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor	1994	2007	25.3	low	0	11	2	0	0
homocitrulline	1	amino acid zwitterion; L-lysine derivative; non-proteinogenic L-alpha-amino acid; ureas	human metabolite; mouse metabolite	1994	1994	30.0	low	0	1	0	0	0
2-oxothiazolidine-4-carboxylic acid	1			2008	2008	16.0	low	0	0	1	0	0
phospho-l-arginine	1	L-arginine derivative; non-proteinogenic L-alpha-amino acid; phosphagen; phosphoamino acid	animal metabolite	2000	2000	24.0	low	0	1	0	0	0
wr 1065	1	alkanethiol; diamine	antioxidant; drug metabolite; radiation protective agent	2000	2000	24.0	low	0	1	0	0	0
s-nitrosoglutathione	1	glutathione derivative; nitrosothio compound	bronchodilator agent; nitric oxide donor; platelet aggregation inhibitor; signalling molecule	2008	2008	16.0	low	0	0	1	0	0
s-methylthiocitrulline	4	imidothiocarbamic ester; L-arginine derivative; L-ornithine derivative; non-proteinogenic L-alpha-amino acid	EC 1.14.13.39 (nitric oxide synthase) inhibitor; neuroprotective agent	1994	2022	22.0	low	1	3	0	0	1
n(g)-iminoethylornithine	2	L-alpha-amino acid		1997	1997	27.0	low	0	2	0	0	0
n(omega)-hydroxyarginine	1	amino acid zwitterion; N(5)-[(E)-amino(hydroxyimino)methyl]ornithine; N(5)-[(hydroxyamino)(imino)methyl]ornithine; N(5)-[(Z)-amino(hydroxyimino)methyl]ornithine; N(5)-[amino(hydroxyimino)methyl]-L-ornithine; N(5)-[amino(hydroxyimino)methyl]ornithine; N(omega)-hydroxy-L-arginine		2003	2003	21.0	low	0	0	1	0	0
2-iminobiotin	1			1997	1997	27.0	low	0	1	0	0	0
omega-n-methylarginine	6	amino acid zwitterion; arginine derivative; guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid		1994	2003	27.5	low	0	5	1	0	0
biotin	2	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite	1997	2005	23.0	low	0	1	1	0	0
sb 203580	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	2012	2012	12.0	low	0	0	0	1	0
canavanine	1	amino acid zwitterion; non-proteinogenic L-alpha-amino acid	phytogenic insecticide; plant metabolite	1997	1997	27.0	low	0	1	0	0	0
nitroarginine	5	guanidines; L-arginine derivative; N-nitro compound; non-proteinogenic L-alpha-amino acid		1996	2000	26.2	low	0	5	0	0	0
1,3-dimethylthiourea	1			2000	2000	24.0	low	0	1	0	0	0
thiourea	29	one-carbon compound; thioureas; ureas	antioxidant; chromophore	1994	2012	24.2	medium	0	20	8	1	0
nadp	1			1994	1994	30.0	low	0	1	0	0	0
dinoprost	1	monocarboxylic acid; prostaglandins Falpha	human metabolite; mouse metabolite	1998	1998	26.0	low	0	1	0	0	0
15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid	1			1998	1998	26.0	low	0	1	0	0	0
tetrodotoxin	1	azatetracycloalkane; oxatetracycloalkane; quinazoline alkaloid	animal metabolite; bacterial metabolite; marine metabolite; neurotoxin; voltage-gated sodium channel blocker	2000	2000	24.0	low	0	1	0	0	0
s-nitroso-n-acetylpenicillamine	2	nitroso compound; nitrosothio compound	nitric oxide donor; vasodilator agent	1999	2005	22.0	low	0	1	1	0	0
oxadiazoles	1			2000	2000	24.0	low	0	1	0	0	0
calcimycin	1	benzoxazole		1995	1995	29.0	low	0	1	0	0	0
9-(tetrahydro-2-furyl)-adenine	1			2000	2000	24.0	low	0	1	0	0	0
heme	5			1994	1997	29.2	low	0	5	0	0	0
sapropterin	1	5,6,7,8-tetrahydrobiopterin	coenzyme; cofactor; diagnostic agent; human metabolite	1998	1998	26.0	low	0	1	0	0	0
zaprinast	2	triazolopyrimidines		2000	2002	23.0	low	0	1	1	0	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's
Anemia, Fanconi	1	2016	2016	8.0	low	0	0	1
Anoxemia	1	1996	1996	28.0	low	1	0	0
Bacterial Disease	1	1997	1997	27.0	low	1	0	0
Bacterial Infections	1	1997	1997	27.0	low	1	0	0
Fanconi Anemia	1	2016	2016	8.0	low	0	0	1
Hypercapnia	1	1996	1996	28.0	low	1	0	0
Hypoxia	1	1996	1996	28.0	low	1	0	0
Muscle Contraction	3	1995	1998	27.3	medium	3	0	0
Muscle Relaxation	3	1995	2008	23.0	medium	2	1	0
Nerve Degeneration	1	1999	1999	25.0	low	1	0	0
Urinary Tract Infections	1	1997	1997	27.0	low	1	0	0

Safety/Toxicity (5)

Article	Year
Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations. Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 58, Issue:1	2000
Effects of selected arginine analogues on sulphur mustard toxicity in human and hairless guinea pig skin keratinocytes. Toxicology and applied pharmacology, , Feb-15, Volume: 163, Issue:1	2000
L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 13, Issue:13	1999
Synergistic protective effects of selected arginine analogues against sulphur mustard toxicity in neuron culture. Toxicology and applied pharmacology, , Mar-01, Volume: 155, Issue:2	1999
l-thiocitrulline: A potent protective agent against the toxicity of sulphur mustard in vitro. Toxicology and applied pharmacology, , Volume: 151, Issue:2	1998

Bioavailability (1)

Article	Year
Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations. Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 58, Issue:1	2000

tissue plasminogen activator

Description

Cross-References

Synonyms (15)

Drug Classes (1)

Pathways (1)

Protein Targets (6)

Potency Measurements

Bioassays (1)

Research

Studies (31)

Study Types

Related Drugs (91)

Drugs in this Class (30)

Drugs Researched Together (61)

Related Conditions (11)

Safety/Toxicity (5)

Bioavailability (1)