Page last updated: 2024-12-06
thiarubrine a
Description
Thiarubrine A is a natural product with a unique structure containing a thiazole ring fused to a pyridone ring. It has been isolated from various Streptomyces species and exhibits potent biological activities, including antimicrobial, anti-inflammatory, and anticancer effects. The compound's synthesis has been studied extensively, leading to several synthetic routes, including a biomimetic approach. Thiarubrine A is a promising lead compound for drug development, particularly for the treatment of infections and inflammatory diseases. Its unique mechanism of action, involving the inhibition of bacterial DNA synthesis and the modulation of inflammatory pathways, has sparked significant research interest. The compound's ability to disrupt bacterial cell wall formation and inhibit the production of pro-inflammatory cytokines makes it a potential candidate for a new class of therapeutic agents.'
thiarubrine A: dithiin polyacetylene; bioactive constituent of Aspilia (Asteraceae); structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Aspilia | genus | A plant genus of the family ASTERACEAE. Members contain thiarubrine A and diterpenes.[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 72386 |
| CHEBI ID | 9538 |
| SCHEMBL ID | 1653142 |
| MeSH ID | M0130703 |
Synonyms (20)
| Synonym |
|---|
| 3-hex-5-en-1,3-diynyl-6-prop-1-ynyl-dithiine |
| thiarubrine a |
| thiarubrin a |
| 63543-09-9 |
| C08461 |
| 3-(5-hexene-1,3-diynyl)-6-(1-propynyl)-1,2-dithiin |
| 1,2-dithiin, 3-(5-hexene-1,3-diynyl)-6-(1-propynyl)- |
| unii-dvv5w0eg1z |
| dvv5w0eg1z , |
| thiarubrin(e) a |
| 1-(2-methyleth-1-yn)-4-(hex-1,3-diyn-5-ene)-2,3-dithiacyclohex-1,3-diene |
| 1,2-dithiin, 3-(5-hexene-1,3-diyn-1-yl)-6-(1-propyn-1-yl)- |
| thiarubrine a [mi] |
| SCHEMBL1653142 |
| CHEBI:9538 |
| DTXSID80212947 |
| LMFA12000371 |
| thiorubrine a |
| 3-(hexa-5-en-1,3-diyn-1-yl)-6-(prop-1-yn-1-yl)-1,2-dithiine |
| Q27108431 |
Drug Classes (1)
| Class | Description |
|---|
| organosulfur heterocyclic compound | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 19.55
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 19.55 (24.57) | | Research Supply Index | 2.20 (2.92) | | Research Growth Index | 4.11 (4.65) | | Search Engine Demand Index | 15.26 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |