Compounds > tetritol
Page last updated: 2024-12-05

tetritol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tetritol is a sugar alcohol with the molecular formula C4H10O4. It is a white, crystalline solid that is soluble in water. Tetritol is a naturally occurring compound found in some plants. It has been studied for its potential use as a sweetener and as a component of dietary supplements. Tetritol has also been investigated for its potential therapeutic effects, such as its ability to reduce blood sugar levels and improve insulin sensitivity. However, more research is needed to fully understand the safety and efficacy of tetritol for these purposes.'

butane-1,2,3,4-tetrol : A tetritol that is butane substituted by hydroxy groups at positions 1, 2, 3 and 4. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID8998
CHEMBL ID402812
CHEBI ID48299
SCHEMBL ID36228
MeSH IDM0042517

Synonyms (32)

Synonym
AKOS005445107
1,2,3,4-butanetetrol, [s-(r*,r*)]-
nsc20660
6968-16-7
nsc-20660
2(r),3(s)-1,2,3,4-butanetetrol
STK368180
1,2,3,4-tetrahydroxybutane
CHEBI:48299 ,
butane-1,2,3,4-tetrol
E-3000
D172AE70-F62C-413D-A64B-686F547D8D77
7541-59-5
CHEMBL402812
butane-1,2,3,4-tetraol
dl-1,2,3,4-butanetetrol
BMSE000100
BMSE000121
FT-0654570
NCGC00248705-01
tetritol
einecs 231-418-3
FT-0625699
FT-0628023
SCHEMBL36228
UNXHWFMMPAWVPI-UHFFFAOYSA-N
1,2,3,4-tetrahydroxybutane, (r*,s*)-
HMS3652N15
DTXSID70859289
SB44878
SB44744
1,2,3,4-butanetetrol, (r*,r*)-(a+/-)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
tetritol
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID314754Inhibition of carbonic anhydrase 9 catalytic domain assessed as residual activity at 2.5 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314748Inhibition of carbonic anhydrase 9 catalytic domain assessed as residual activity at 0.1 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314744Inhibition of carbonic anhydrase 2 assessed as residual activity at 0.01 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314741Inhibition of carbonic anhydrase 2 assessed as residual activity at 0.001 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314755Inhibition of carbonic anhydrase 9 assessed as residual activity at 2.5 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314758Inhibition of carbonic anhydrase 9 assessed as residual activity at 10 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314746Inhibition of carbonic anhydrase 9 assessed as residual activity at 0.01 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314751Inhibition of carbonic anhydrase 9 catalytic domain assessed as residual activity at 1.0 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314747Inhibition of carbonic anhydrase 2 assessed as residual activity at 0.1 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314749Inhibition of carbonic anhydrase 9 assessed as residual activity at 0.1 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314743Inhibition of carbonic anhydrase 9 assessed as residual activity at 0.001 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314745Inhibition of carbonic anhydrase 9 catalytic domain assessed as residual activity at 0.01 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314742Inhibition of carbonic anhydrase 9 catalytic domain assessed as residual activity at 0.001 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314756Inhibition of carbonic anhydrase 2 assessed as residual activity at 10 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314750Inhibition of carbonic anhydrase 2 assessed as residual activity at 1.0 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314753Inhibition of carbonic anhydrase 2 assessed as residual activity at 2.5 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314757Inhibition of carbonic anhydrase 9 catalytic domain assessed as residual activity at 10 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
AID314752Inhibition of carbonic anhydrase 9 assessed as residual activity at 1.0 mM2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.83

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.83 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.83)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sorbitol
[no description available]		1.9310hexitol
mercaptoethanol
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.		2.0410alkanethiol;
primary alcohol		geroprotector
acetazolamide
Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)		2.0410monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
mannitol
[no description available]		2.0310mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
dithiothreitol
1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.		2.04101,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
tris(2-carboxyethyl)phosphine
tris(2-carboxyethyl)phosphine: water-soluble reagent which irreversibly reduces disulfides to thiols at room temperature & is active below neutral pH; used for quantitation of iodine and iodate. TCEP : A tertiary phosphine in which phosphane is substituted with three 2-carboxyethyl groups. It is a commonly used reducing agent.		2.0410phosphine derivative;
tricarboxylic acid		reducing agent
ConditionIndicatedRelationship StrengthStudiesTrials