Compounds > tetramethylsuccinonitrile
Page last updated: 2024-12-06

tetramethylsuccinonitrile

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID18745
CHEMBL ID3182970
SCHEMBL ID576290
MeSH IDM0111341

Synonyms (56)

Synonym
tetramethylbutanedinitrile
succinonitrile, tetramethyl-
nsc39746
wln: ncx1&1&x1&1&cn
3333-52-6
tetramethylsuccinonitrile
butanedinitrile, tetramethyl-
tetramethylsuccinodinitrile
nsc-39746
tetramethylsuccinotrile
tetramethylsuccinic acid dinitrile
ai3-23333
hsdb 7193
nsc 39746
tetramethylsukcinonitril [czech]
tetramethyl succinonitrile
tmsn
brn 1752813
2,2,3,3-tetramethylbutanedinitrile
ccris 1551
cp 75475
inchi=1/c8h12n2/c1-7(2,5-9)8(3,4)6-10/h1-4h3
zvqxqpnjhrngid-uhfffaoysa-
AKOS003333998
FT-0695327
2,3-dicyano-2,3-dimethylbutane
T0155
NCGC00248713-01
4-02-00-02054 (beilstein handbook reference)
116xmu2ghk ,
tetramethylsukcinonitril
unii-116xmu2ghk
NCGC00258127-01
dtxcid406125
tox21_200573
dtxsid0026125 ,
cas-3333-52-6
2,2,3,3-tetramethyl-butanedinitrile
SCHEMBL576290
tetramethylsuccinonitrile [hsdb]
butanedinitrile, 2,2,3,3-tetramethyl-
2,2,3,3-tetramethylsuccinonitrile
2,2,3,3-tetramethyl-succinonitrile
2,2,3,3-tetramethylsuccinonitrile #
ZVQXQPNJHRNGID-UHFFFAOYSA-N
CHEMBL3182970
mfcd00040683
BBL104218
STL558082
Q7706592
dl-1,4-bis-o-(phenylmethyl)-myoinositol
D92309
BS-43981
SY051169
CS-0154962
EN300-198103

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"The acute rat oral LD50 for tetramethylsuccinonitrile (TMSN) is 38."( Subchronic toxicity of tetramethylsuccinonitrile.
Johannsen, FR; Levinskas, GJ, 1986)		0.88
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency17.43940.000714.592883.7951AID1259369
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency69.42750.003041.611522,387.1992AID1159552
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.00160.001530.607315,848.9004AID1224849
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency22.145619.739145.978464.9432AID1159509
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (60.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's1 (10.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.47 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.69 (4.65)
Search Engine Demand Index25.55 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
n,n-dimethylaniline
N,N-dimethylaniline: RN given refers to parent cpd; structure. dimethylaniline : A methylaniline carrying at least two methyl groups.. N,N-dimethylaniline : A tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups.		1.9810dimethylaniline;
tertiary amine
cyanides
Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.		2.3520pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
n-nitrosomorpholine
N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.		1.9810nitrosaminecarcinogenic agent;
mutagen
quinethazone
quinethazone: RN given for cpd without isomeric designation. quinethazone : A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension.		1.9810quinazolinesantihypertensive agent;
diuretic
azobis(isobutyronitrile)
azobis(isobutyronitrile): blowing agent for elastomers & plastics; initiator for free radical reactions; structure		210
4-nitrophthalimide
4-nitrophthalimide: structure given in first source		1.9810
succinonitrile
succinonitrile: structure		1.9610
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		1.9810azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
alkenes
[no description available]		2.610
azidotrimethylsilane
azidotrimethylsilane: structure in first source		2.610
ConditionIndicatedRelationship StrengthStudiesTrials
Fasting Hypoglycemia
HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.		02.110
Absence Seizure
[description not available]		02.110
Hypoglycemia
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.		02.110
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.110
Diseases, Occupational
[description not available]		01.9310
Abnormalities, Autosome
[description not available]		01.9810
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9610