suillin profile

suillin: isol from Suillus granulatus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5387599
CHEMBL ID	485467
CHEBI ID	190366
MeSH ID	M0170860

Synonyms (17)

Synonym
NSC625110 ,
suillin
nsc-625110
1,4-benzenetriol, 3-(3,7,11,15-tetramethyl)-2,6,10,14-hexadecatetraenyl)- 4-acetate, (e,e,e)-
103538-03-0
[3,4-dihydroxy-2-[(2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]phenyl] acetate
1,2,4-benzenetriol, 3-(3,7,11,15-tetramethyl)-2,6,10, 14-hexadecatetraenyl)- 4-acetate, (e,e,e)-
3,4-dihydroxy-2-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)phenyl acetate
CHEMBL485467
tetraprenylphenolsuillin
1,2,4-benzenetriol, 3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-, 4-acetate, (e,e,e)-
4-acetoxy-3-geranylgeranyl-1,2-dihydroxybenzene
CHEBI:190366
unii-v324ra58sa
nsc 625110
v324ra58sa ,
1,2,4-benzenetriol, 3-[(2e,6e,10e)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-, 4-acetate

Research Excerpts

Treatment

Excerpt	Reference	Relevance
"Iso-suillin-treated K562 cells exhibited an increased rate of apoptosis, mitochondrial membrane potential (MMP) depolarization, and G0/G1 arrest."	( Iso-suillin from the mushroom Suillus flavus induces cell cycle arrest and apoptosis in K562 cell line. Wang, LA; Wang, Y; Zhang, J; Zhang, Q; Zhao, J; Zhao, X, 2014)	1.44

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
diterpenoid	Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID359654	Cytotoxicity against human KB cells after 72 hrs by MTT assay	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus.
AID359657	Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus.
AID336908	Cytotoxicity against human NSCLC-N6 cells
AID336906	Cytotoxicity against human KB cells
AID336907	Cytotoxicity against mouse P388 cells
AID336910	In vivo antitumor activity against mouse P388 cells at 10 mg/kg, ip administered on 1,5 and 9 days relative to control
AID359659	Cytotoxicity against human NSCLC-N6 cells after 72 hrs by MTT assay	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus.
AID336909	In vivo antitumor activity against mouse P388 cells at 5 mg/kg, ip administered on 1,5 and 9 days relative to control
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	2 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ergosterol [no description available]	2.15	1	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.13	1	0

Condition	Relationship Strength	Studies
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.98	1
Carcinoma, Non-Small Cell Lung [description not available]	2.31	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.31	1
Hepatocellular Carcinoma [description not available]	2.1	1
Cancer of Liver [description not available]	2.1	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.1	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.1	1
Carcinoma, Small Cell Lung [description not available]	2.13	1
Small Cell Lung Carcinoma A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).	2.13	1

suillin

Description

Cross-References

Synonyms (17)

Research Excerpts

Treatment

Drug Classes (1)

Bioassays (8)

Research

Studies (8)

Study Types

suillin

Description

Cross-References

Synonyms (17)

Research Excerpts

Treatment

Drug Classes (1)

Bioassays (8)

Research

Studies (8)

Study Types

Related Drugs (2)

Related Conditions (9)