Page last updated: 2024-12-08

substance p (6-11), pglu(6)-

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

substance P (6-11), pGlu(6)-: pyroglutamic acid deriv of the C-terminal of Substance P [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID188348
CHEMBL ID441061
MeSH IDM0086415

Synonyms (22)

Synonym
61123-13-5
CHEMBL441061 ,
6-pglu-substance p (6-11)
substance p (6-11), pglu(6)-
l-methioninamide, 5-oxo-l-prolyl-l-phenylalanyl-l-phenylalanylglycyl-l-leucyl-
6-pglu-sp(6-11)
substance p, c-terminal pentapeptide
5-oxo-pro-phe-phe-gly-leu-met-amide
substance p (6-11), pyroglutamic acid-
e-sp(7-11)
substance p (6-11), hexapeptide-pglu(6)-
pglu6-phe-phe-gly-leu-met-nh2
bdbm50007963
(2s)-n-[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-oxopyrrolidine-2-carboxamide
pglu-phe-phe-gly-leu-met-nh2
glp-phe-phe-gly-leu-met-nh2
(s)-n-((5s,8s,14s,17s)-14-benzyl-5-carbamoyl-8-isobutyl-7,10,13,16-tetraoxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadecan-17-yl)-5-oxopyrrolidine-2-carboxamide
n-{14-benzyl-7,10,13,16-tetrahydroxy-5-[hydroxy(imino)methyl]-8-(2-methylpropyl)-18-phenyl-2-thia-6,9,12,15-tetraazaoctadeca-6,9,12,15-tetraen-17-yl}-5-hydroxy-3,4-dihydro-2h-pyrrole-2-carboximidic acid
DTXSID50976640
CS-0621309
[glp6] substance p (6-11)
HY-P3799
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID144420Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
AID175878Inhibitory effect was measured on electrically stimulated rat vas deferens contraction1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
AID78838Effective dose was measured on guinea pig ileum for maximal contraction1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
AID230245Ratio of NK-1 receptor to that of NK-3 receptor1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
AID144550Effective dose was measured on NK3 receptors of guinea pig ileum for maximal contraction in the presence of 10e-7 M substance P methyl ester1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
AID79360Relative potency as ratio of the EC50 value of analogue to that of [PGlu6]SP6-11 in tachykinin receptor 3 in guinea pig ileum1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (76.92)18.7374
1990's3 (23.08)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.48 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]