Page last updated: 2024-11-13

spironolactone, althiazide drug combination

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

spironolactone, althiazide drug combination: combination of spironolactone and althiazide for treatment of benign essential hypertension [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID86277930
MeSH IDM0538934

Synonyms (9)

Synonym
aldactacine
prinactizide
spironolactone, althiazide drug combination
spiroctazine
pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, mixt. with 6-chloro-3,4-dihydro-3-((2-propenylthio)methyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
practazin
76270-06-9
spironolactone and althiazide
aldactazine

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"6%), and a low rate of adverse effects."( Aldactazine/captopril combination, safe and effective in mild to moderate systemic hypertension: report on a multicenter study of 967 patients.
Capron, MH; Pelletier, B; Schohn, DC; Spiesser, R; Wehrlen, M, 1990
)
0.28

Dosage Studied

ExcerptRelevanceReference
" There was a marked dose-response relation between NE and AII administration and mean (NE) or diastolic (AII) blood pressure (BP)."( Effects of a potassium-sparing/thiazide diuretic combination on cardiovascular reactivity to vasopressor agents.
Jahn, HA; Schohn, DC, 1990
)
0.28
" Despite the universal inclusion of asparaginase in such treatment protocols, debate on the optimal formulation and dosage of these agents continues."( L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase.
Baruchel, A; Boos, J; Goekbuget, N; Hunger, SP; Pieters, R; Pui, CH; Rizzari, C; Schrappe, M; Silverman, L, 2011
)
0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (38.46)18.7374
1990's5 (38.46)18.2507
2000's2 (15.38)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.36 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (30.77%)5.53%
Reviews1 (7.69%)6.00%
Case Studies3 (23.08%)4.05%
Observational0 (0.00%)0.25%
Other5 (38.46%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]