shionone: isolated from roots of Aster auriculatus Franch; RN not in Chemline 5/88; RN from Chemical Abstracts Index Guide; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
shionone : A tetracyclic triterpenoid that is perhydrochrysene which is substituted by methyl groups at positions 1, 4bbeta, 6aalpha, 8beta, 10abeta and 12a positions, by a 4-methylpent-3-enyl group at the 8alpha position, and with an oxo group at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Aster | genus | [no description available] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| Aster auriculatus | species | [no description available] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 12315507 |
| CHEBI ID | 63459 |
| MeSH ID | M0156605 |
| Synonym |
|---|
| shionone |
| 10376-48-4 |
| C17966 |
| bt0amd31ub , |
| unii-bt0amd31ub |
| d:a-friedo-18,19-secolup-19-en-3-one |
| (1r,4as,4bs,6as,8r,10ar,10bs,12as)-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methylpent-3-en-1-yl)hexadecahydrochrysen-2(1h)-one |
| CHEBI:63459 |
| AC-35082 |
| d-homo-5.alpha.-androstan-17-one, 3.alpha.,5,8,17a.beta.-tetramethyl-3-(4-methyl-3-pentenyl)- |
| shionone [mi] |
| 2(1h)-chrysenone, hexadecahydro-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methyl-3-pentenyl)-, (1r-(1.alpha.,4a.beta.,4b.alpha.,6a.beta.,8.beta.,10a.alpha.,10b.beta.,12a.alpha.))- |
| 2(1h)-chrysenone, hexadecahydro-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methyl-3-penten-1-yl)-, (1r,4as,4bs,6as,8r,10ar,10bs,12as)- |
| FT-0697220 |
| AKOS030573546 |
| mfcd06799428 |
| Q27132632 |
| HY-N0829 |
| CS-0009860 |
| MS-27538 |
| (1r,4as,4bs,6as,8r,10ar,10bs,12as)-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methylpent-3-enyl)-1,3,4,4a,5,6,7,9,10,10b,11,12-dodecahydrochrysen-2-one |
Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus. It has been reported to possess marked anti-inflammatory properties.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, and it has been reported to possess marked anti-inflammatory properties. " | ( Shionone alleviates NLRP3 inflammasome mediated pyroptosis in interstitial cystitis injury. Fan, L; Fei, X; Jin, Q; Luo, J; Peng, J; Tang, H; Tang, X; Wang, X; Xue, Y; Yin, H; Zhang, J; Zhou, Y, 2021) | 3.51 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Shionone treatment significantly attenuated the bladder wet weight, score of edema and hemorrhage, enhanced the viability of SV-HUC-1 cell, decreased the rate of pyroptosis." | ( Shionone alleviates NLRP3 inflammasome mediated pyroptosis in interstitial cystitis injury. Fan, L; Fei, X; Jin, Q; Luo, J; Peng, J; Tang, H; Tang, X; Wang, X; Xue, Y; Yin, H; Zhang, J; Zhou, Y, 2021) | 2.79 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The developed method was successfully applied to the pharmacokinetic study of shionone and epi-friedelinol after oral administration of Aster tataricus extract to rats." | ( Development and validation of an LC/MS/MS method for simultaneous determination of shionone and epi-friedelinol in rat plasma for pharmacokinetic study after oral administration of Aster tataricus extract. Deng, J; Hu, L; Liu, JT; Liu, Y; Wang, SP; Xiong, Y; Yin, DF; Zhong, W; Zhou, K, 2016) | 0.89 |
| Class | Description |
|---|---|
| tetracyclic triterpenoid | Any triterpenoid consisting of a tetracyclic skeleton. |
| cyclic terpene ketone | An alicyclic ketone in which the carbocyclic ring structure forms part of a terpene skeleton. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.07) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||