senecionine N-oxide: isolated from Senecio vulgaris L.; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Senecio | genus | A species of toxic plants of the Compositae. The poisonous compounds are alkaloids which cause cattle diseases, neoplasms, and liver damage and are used to produce cancers in experimental animals.[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| Senecio vulgaris | species | [no description available] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 5380876 |
| CHEMBL ID | 471683 |
| CHEBI ID | 52070 |
| MeSH ID | M0159300 |
| Synonym |
|---|
| nsc 106677 |
| senecionine oxide |
| senecionan-11,16-dione, 12-hydroxy-, 4-oxide |
| 12-hydroxysenecionan-11,16-dione 4-oxide |
| (1,6)dioxacyclododecino(2,3,4-gh)pyrrolizine-3,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, 12-oxide, (3z,5r,6r,14ar,14br)- |
| senecionine, n-oxide |
| nsc106677 , |
| 13268-67-2 |
| senecionine n-oxide |
| nsc-106677 |
| CHEBI:52070 , |
| CHEMBL471683 |
| senecionin-n-oxid |
| AKOS037515349 |
| (5r,6r,9a1r,14ar,z)-3-ethylidene-6-hydroxy-5,6-dimethyl-2,7-dioxo-2,3,4,5,6,7,9,9a1,11,13,14,14a-dodecahydro-12h-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine 12-oxide |
| (1r,4z,6r,7r,17r)-4-ethylidene-7-hydroxy-6,7-dimethyl-14-oxido-2,9-dioxa-14-azoniatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione |
| Q27104786 |
| DTXSID901016615 |
| CS-0062870 |
| HY-N6637 |
| E80698 |
| senecionine-n-oxide 100 microg/ml in water |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The rat LD50 of most alkaloids known to be significant for human health are in the range of 34-300 mg/kg." | ( Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo. Halasková, M; Peterka, M; Roeder, E; Sarin, S; Wiedenfeld, H, 1994) | 0.29 |
| " As a continuation of our investigation into the safety assessment of PA-containing herbal medicines, the toxicity and toxicokinetic characteristics of senecionine N-oxide (a representative toxic PA N-oxide) were investigated by using the UDP-glucuronosyltransferase 1A4 humanized mouse model (hUGT1A4 mouse model) and compared with those in wild-type mice simultaneously." | ( Species difference in toxicokinetics and safety assessment of senecionine N-oxide in a UDP-glucuronosyltransferase 1A4 humanized mouse model. Chen, Y; Ding, L; Liu, P; Tang, Y; Wang, C; Wang, J; Wang, W; Wang, Z; Xiong, A; Yang, L, 2023) | 1.35 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " PA N-oxide-induced hepatotoxicity was further confirmed on mice orally dosed of herbal extract containing 170 μmol PA N-oxides/kg/day, with its hepatotoxicity similar to but potency much lower than the corresponding PAs." | ( First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans. Fu, PP; Gao, H; Li, N; Lin, G; Ma, J; Ruan, J; Wang, J; Xue, J; Yang, M; Ye, Y, 2017) | 0.46 |
| Class | Description |
|---|---|
| tertiary amine oxide | An N-oxide where there are three organic groups bonded to the nitrogen atom. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID339034 | Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay | |||
| AID1110932 | Nematicidal activity against juvenile stage of Heterodera schachtii assessed as inhibition of mobility after 168 hr | 2009 | Pest management science, Jul, Volume: 65, Issue:7 | Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes. |
| AID1110936 | Nematicidal activity against juvenile stage of Meloidogyne incognita (root-knot nematode) assessed as inhibition of mobility after 20 hr | 2009 | Pest management science, Jul, Volume: 65, Issue:7 | Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes. |
| AID1110931 | Nematicidal activity against juvenile stage of Meloidogyne incognita (root-knot nematode) assessed as inhibition of mobility after 168 hr | 2009 | Pest management science, Jul, Volume: 65, Issue:7 | Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes. |
| AID1110926 | Nematicidal activity against juvenile stage of Heterodera schachtii assessed as inhibition of mobility incubated for 168 hr followed by compound wash out measured after 24 hr | 2009 | Pest management science, Jul, Volume: 65, Issue:7 | Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes. |
| AID1110927 | Nematicidal activity against juvenile stage of Meloidogyne incognita (root-knot nematode) assessed as inhibition of mobility incubated for 168 hr followed by compound wash out measured after 24 hr | 2009 | Pest management science, Jul, Volume: 65, Issue:7 | Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes. |
| AID1110937 | Nematicidal activity against juvenile stage of Heterodera schachtii assessed as inhibition of mobility after 20 hr | 2009 | Pest management science, Jul, Volume: 65, Issue:7 | Effects of pyrrolizidine alkaloids on the performance of plant-parasitic and free-living nematodes. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.03) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||