Page last updated: 2024-11-12

segetalin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

segetalin B: isolated from Vaccaria segetalis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
VaccariagenusA plant genus of the family CARYOPHYLLACEAE. The common name Soapwort is also used with SAPONARIA.[MeSH]CaryophyllaceaeA plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. The species are diverse in appearance and habitat; most have swollen leaf and stem joints.[MeSH]

Cross-References

ID SourceID
PubMed CID10345235
CHEMBL ID386632
SCHEMBL ID151686
MeSH IDM0267180

Synonyms (11)

Synonym
segetalin b
CHEMBL386632
SCHEMBL151686
164991-89-3
segetalin-b
(3s,6s,9s,12s)-6-(1h-indol-3-ylmethyl)-3,9-dimethyl-12-propan-2-yl-1,4,7,10,13-pentazacyclopentadecane-2,5,8,11,14-pentone
MS-29005
HY-107245
E88615
CS-0027753
AKOS040760076

Research Excerpts

Overview

Segetalin B (SB) is a cyclic peptide compound showing estrogenic activity.

ExcerptReferenceRelevance
"Segetalin B (SB) is a cyclic peptide compound showing estrogenic activity."( SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation.
Cheng, Q; Lan, X; Luo, J; Ma, H; Xiao, Y; Yuan, Z; Zou, L, 2022
)
1.68
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID270574Vasocontractile effect on norepinephrine-induced contraction of rat thoracic aortic ring without endothelium at 100 uM2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
AID270572Vasocontractile effect on norepinephrine-induced contraction of rat thoracic aortic ring with endothelium at 100 uM2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
AID270571Vasorelaxation effect against norepinephrine-induced contraction of rat thoracic aortic ring with endothelium at 100 uM2006Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis.
AID402827Estrogen-like activity in ovariectomized SD rat assessed as increase in uterus weight at 2.5 mg/kg, sc administered daily for 14 days1997Journal of natural products, Mar, Volume: 60, Issue:3
Cyclic peptides from higher plants. 34. Segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.77

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.77 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.77)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]