Compounds > sc70303
Page last updated: 2024-11-13

sc70303

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

SC70303: potassium salt of the open lactone ring of eplerenone; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23670437
SCHEMBL ID10948684
MeSH IDM0385594

Synonyms (14)

Synonym
eplerenone hydroxyacid potassium salt
95716-98-6
pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, 7-methyl ester, potassium salt (1:1), (7.alpha.,11.alpha.,17.alpha.)-
SCHEMBL10948684
eplerenone hydroxyacid potassium
sc-70303 ,
pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, 7-methyl ester, potassium salt (1:1), (7alpha,11alpha,17alpha)-
unii-1385q51vem
sc70303
1385q51vem ,
eplerenone ep impurity f potassium salt
potassium;3-[(1r,2s,9r,10r,11s,14r,15s,17r)-14-hydroxy-9-methoxycarbonyl-2,15-dimethyl-5-oxo-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-en-14-yl]propanoate
Q27251491
9,11alpha-epoxy-17-hydroxy-7alpha-(methoxycarbonyl)-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid potassium salt

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" A population pharmacokinetic model incorporating protein binding and the reversible relationship between eplerenone and SC-70303 was developed."( A population approach to eplerenone pharmacokinetics and saturable protein binding.
Chiba, K; Mori, Y; Ogata, H; Takahashi, H, 2010)		0.36

Dosage Studied

ExcerptRelevanceReference
", oral, and rectal dosing (15 mg/kg) and following intragastric, intraduodenal, intrajejunal, and intracolonic dosing (7."( Absorption and disposition of a selective aldosterone receptor antagonist, eplerenone, in the dog.
Cook, CS; Fischer, JS; Zhang, L, 2000)		0.31
" The pharmacokinetics of eplerenone (EP) were examined in rats following single or repeated dosing with (14)C-labelled or unlabelled EP to characterize absorption, metabolism and excretion."( Single- and repeated-dose pharmacokinetics of eplerenone, a selective aldosterone receptor blocker, in rats.
Ames, GB; Cook, CS; Fischer, J; Levin, S; Zhang, J; Zhang, L, 2003)		0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
spironolactone
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.		4.5513-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
aldosterone
[no description available]		2.011011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
eplerenone
Eplerenone: A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.		4.5513-oxo-Delta(4) steroid;
epoxy steroid;
gamma-lactone;
methyl ester;
organic heteropentacyclic compound;
oxaspiro compound;
steroid acid ester		aldosterone antagonist;
antihypertensive agent
ConditionIndicatedRelationship StrengthStudiesTrials