phenoptin: a calcium channel blocker reported in 2 Russian articles; no other info available 12/85; see Verapamil, Finoptin is a TRD which could be a translation variant of fenoptin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
sapropterin dihydrochloride : The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 135409471 |
| CHEMBL ID | 1201775 |
| CHEBI ID | 32120 |
| SCHEMBL ID | 258963 |
| MeSH ID | M0517997 |
| Synonym |
|---|
| sun-0588 |
| phenoptin |
| sapropterin dihydrochloride |
| dapropterin dihydrochloride |
| biobuden |
| kuvan |
| t-1401 |
| bipten |
| biopten |
| (6r)-5,6,7,8-tetrahydrobiopterin dihydrochloride |
| t1401 , |
| sun 0588 |
| sapropterin hydrochloride |
| (6r)-2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1h)-pteridinone dihydrochloride |
| (6r)-tetrahydrobiopterin hydrochloride |
| 4(1h)-pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6r-(6r*(1r*,2s*)))- |
| sapropterin dihydrochloride (usan) |
| sapropterin hydrochloride (jan) |
| kuvan (tn) |
| D01798 |
| biopten (tn) |
| 69056-38-8 |
| tetrahydrobiopterin dihydrochloride |
| (6r)-2-amino-6-[(1r,2s)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1h)-one dihydrochloride |
| sun-0588 (shiratori) |
| CHEMBL1201775 |
| dapropterin hydrochloride |
| t1401 (biomarin) |
| CHEBI:32120 , |
| (6r)-tetrahydrobiopterin dihydrochloride |
| sapropterin 2hcl |
| (6r)-2-amino-6-[(1r,2s)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3h)-one dihydrochloride |
| (6r)-5,6,7,8-tetrahydro-l-biopterin dihydrochloride |
| dtxsid0040620 , |
| cas-69056-38-8 |
| tox21_111782 |
| dtxcid8020620 |
| S9568 |
| sapropterin hcl |
| shiratori sn 0588 |
| biomarin t 1401 |
| rg277lf5b3 , |
| sapropterin dihydrochloride [usan] |
| unii-rg277lf5b3 |
| (6beta)-5,6,7,8-tetrahydro-l-biopterin dihydrochloride |
| tetrahydrobiopterin (thb) dihydrochloride |
| (r)-2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3h)-one dihydrochloride |
| sapropterin dihydrochloride [orange book] |
| (6r)-l-erythro-tetrahydrobiopterin dihydrochloride |
| (6.beta.)-5,6,7,8-tetrahydro-l-biopterin dihydrochloride |
| 4(1h)-pteridinone,2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, (6r)- |
| sapropterin hydrochloride [mart.] |
| (6r)-2-amino-6-[(1r,2s)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1h)-pteridinone dihydrochloride |
| sapropterin dihydrochloride [who-dd] |
| sapropterin hydrochloride [jan] |
| sapropterin dihydrochloride [mi] |
| sapropterin dihydrochloride [vandf] |
| (-)-(6r)-2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3h)-pteridinone dihydrochloride |
| SCHEMBL258963 |
| (r)-2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1h)-one dihydrochloride |
| AC-30208 |
| CS-5740 |
| sapropterin (dihydrochloride) |
| HY-A0124A |
| (6r)-2-amino-6-[(1r,2s)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1h-pteridin-4-one;dihydrochloride |
| BS-17377 |
| Q27114793 |
| BCP09678 |
| EX-A7412 |
| mfcd00891665 |
| 6r-bh4 dihydrochloride |
| 6r-tetrahydro-l-biopterin dihydrochloride |
| D82236 |
| tetrahydrobiopterin (thb) dihydrochloride is known as an activating nos cofactor. |
| AKOS016842774 |
| AKOS037649224 |
| (r)-2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1h)-onedihydrochloride |
| tetrahydro-l-biopterin 2hcl |
| sapropterin dihcl |
| (6r)-2-amino-6-[(1r,2s)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3h-pteridin-4-one;dihydrochloride |
| c9h17cl2n5o3 |
| (6r)-2-amino-6-((1r,2s)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3h)-one dihydrochloride |
| sapropterin hydrochloride (mart.) |
| javygtor |
| Excerpt | Reference |
|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) |
| Role | Description |
|---|---|
| diagnostic agent | A substance administered to aid diagnosis of a disease. |
| coenzyme | A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| hydrochloride | A salt formally resulting from the reaction of hydrochloric acid with an organic base. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 0.0178 | 9.6374 | 44.6684 | AID588834 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (20.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||