Page last updated: 2024-10-14

saliphenylhalamide

Description

saliphenylhalamide: a V-ATPase inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11271117
CHEMBL ID457538
MeSH IDM0576336

Synonyms (5)

Synonym
CHEMBL457538
saliphenylhalamide
saliphe
GLXC-25513
n-[(e)-3-[(4s,6r,7s,9e)-6,16-dihydroxy-7-methyl-2-oxo-3-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraen-4-yl]prop-1-enyl]-3-phenylprop-2-ynamide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID392116Cytotoxicity against human HOS cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392110Cytotoxicity against human HCT15 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392118Cytotoxicity against human AsPC1 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392124Cytotoxicity against human NCI-H1299 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392121Cytotoxicity against human MCF7/DX cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID1251288Inhibition of purified reconstituted bovine brain V-ATPase2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs.
AID392127Growth inhibition of human HME50T cells at 100 nM2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392125Cytotoxicity against human A549 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392109Cytotoxicity against human HCT116 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392112Cytotoxicity against human SW480 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392115Cytotoxicity against human A2058 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392107Cytotoxicity against human HepG2 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392123Cytotoxicity against human NCI-H460 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392119Cytotoxicity against human PANC1 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392120Cytotoxicity against human MCF7 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392114Cytotoxicity against human SK-MEL-28 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392122Cytotoxicity against human MDA-MB-231 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392111Cytotoxicity against human HT-29 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392117Cytotoxicity against human MG63 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392126Cytotoxicity against human SKMES1 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID1251290Growth inhibition of human HCC4017 cells assessed as reduction in cell viability at 0.1 nM to 10 uM2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs.
AID392113Cytotoxicity against human SK-MEL-5 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
AID392108Cytotoxicity against human SKHEP1 cells expressing vacuolar ATPase2008Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's7 (87.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]