Compounds > saikogenin f

Page last updated: 2024-11-13

saikogenin f

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

saikogenin F: a saikosapogenin from roots of Bupleurium smithii var. parvifolium [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	21594261
CHEMBL ID	3542345
SCHEMBL ID	1046332
MeSH ID	M0404975

Synonyms (9)

Synonym
saikogenin f
SCHEMBL1046332
CHEMBL3542345
14356-59-3
MS-28754
(1s,2s,4s,5r,8r,9r,10s,13s,14r,17s,18r)-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-ene-2,10-diol
CS-0135171
HY-N7670
AKOS040763726

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID1293539	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1219349	Drug level in Sprague-Dawley rat assessed as retention time treated with saikosaponin a by LC-DAD-IT-TOF-MS analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 41, Issue:3	Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
AID1293535	Neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells assessed as cell viability at 50 uM pretreated for 12 hrs followed by H2O2 addition measured after 3 hrs by MTT assay relative to control	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1293541	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1293536	Neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells assessed as cell viability at 25 uM pretreated for 12 hrs followed by H2O2 addition measured after 3 hrs by MTT assay relative to control	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1219343	Drug excretion in Sprague-Dawley rat feces treated with saikosaponin a at 15 mg/kg, iv by LC-DAD-IT-TOF-MS analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 41, Issue:3	Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
AID1293542	Neuroprotective activity against H2O2-induced neuronal cell death in human SH-SY5Y cells assessed as cell viability at 100 uM pretreated for 12 hrs followed by H2O2 addition measured after 3 hrs by MTT assay relative to control	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1293540	Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1219347	Drug excretion in Sprague-Dawley rat feces treated with saikosaponin a at 50 mg/kg, po administered through gavage by LC-DAD-IT-TOF-MS analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 41, Issue:3	Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
AID1293538	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1293537	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6	Neuroprotective oleanane triterpenes from the roots of Bupleurum chinense.
AID1219350	Drug recovery in po dosed rat excreted feces measured over 0 to 24 hrs after drug administration by HPLC analysis relative to starting drug dose	2013	Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 41, Issue:3	Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
AID1219311	Drug excretion in Sprague-Dawley rat urine treated with saikosaponin a at 50 mg/kg, po administered through gavage by LC-DAD-IT-TOF-MS analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 41, Issue:3	Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (14.29)	18.2507
2000's	1 (14.29)	29.6817
2010's	3 (42.86)	24.3611
2020's	2 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.98 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	5.06 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.98)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
benzoic acid Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.	2.6	1	0	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite
aconitic acid Aconitic Acid: A tricarboxylic acid with the formula (COOH)-CH2-C(COOH)=CH-COOH.. aconitic acid : A tricarboxylic acid that is prop-1-ene substituted by carboxy groups at positions 1, 2 and 3.	2.6	1	0	tricarboxylic acid
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.13	1	0	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
thiazoles [no description available]	2.02	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
oleanolic acid [no description available]	2.77	3	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [no description available]	2.13	1	0	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.02	1	0	organic bromide salt	colorimetric reagent; dye
saikogenin a saikogenin A: RN given refers to (3beta,4alpha,16beta)-isomer; structure	2.53	2	0
saikosaponin d [no description available]	2.46	2	0
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.02	1	0	prostaglandins E	human metabolite; mouse metabolite; oxytocic
beta-escin [no description available]	2.97	4	0
sapogenins Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.	2.97	4	0

Condition	Indicated	Relationship Strength	Studies	Trials
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	2.6	1	0
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	0	2.6	1	0