s-(4-nitrobenzyl)glutathione

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

S-(4-nitrobenzyl)glutathione: metabolite of 4-nitrotoluene [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

S-(4-nitrobenzyl)glutathione : An S-substituted glutathione in which the thiol hydrogen of glutathione is replaced by a 4-nitrobenzyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	97538
CHEBI ID	87407
SCHEMBL ID	2089788
MeSH ID	M0115599

Synonyms (19)

Synonym
6803-19-6
s-(p-nitrobenzyl)glutathione
GTB ,
s-(4-nitrobenzyl)glutathione
DB03686
(2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-[(4-nitrophenyl)methylsulfanyl]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
A835983
glycine, n-(n-l-gamma-glutamyl-s-((4-nitrophenyl)methyl)-l-cysteinyl)-
nsc 131122
SCHEMBL2089788
l-gamma-glutamyl-s-[(4-nitrophenyl)methyl]-l-cysteinylglycine
CHEBI:87407
l-gamma-glutamyl-s-(4-nitrobenzyl)-l-cysteinylglycine
Q27159603
s-(p-nitrobenzyl)-glutathione
(s)-2-amino-5-((r)-1-(carboxymethylamino)-3-(4-nitrobenzylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid
CS-0616363
HY-148208
(s)-2-amino-5-(((r)-1-((carboxymethyl)amino)-3-((4-nitrobenzyl)thio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

Class	Description
C-nitro compound	A nitro compound having the nitro group (-NO2) attached to a carbon atom.
organic sulfide	Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers.
S-substituted glutathione	A glutathione derivative that is glutathione in which the hydrogen of the thiol has been replaced by any other group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	3 (42.86)	18.2507
2000's	1 (14.29)	29.6817
2010's	2 (28.57)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.82 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.90 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.82)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dinitrochlorobenzene Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.	2.06	1	C-nitro compound; monochlorobenzenes	allergen; epitope; sensitiser
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	6.96	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
iodoacetic acid Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.. iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.	1.99	1	haloacetic acid; organoiodine compound	alkylating agent
dithionitrobenzoic acid Dithionitrobenzoic Acid: A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.. dithionitrobenzoic acid : An organic disulfide that results from the formal oxidative dimerisation of 2-nitro-5-thiobenzoic acid. An indicator used to quantify the number or concentration of thiol groups.	2.06	1	nitrobenzoic acid; organic disulfide	indicator
4-nitrotoluene 4-nitrotoluene: RN given refers to parent cpd; structure in Merck Index, 9th ed, #6470. mononitrotoluene : A nitrotoluene bearing a single nitro substituent at any position. A "closed class".. 4-nitrotoluene : A mononitrotoluene that consists of toluene bearing a nitro substituent at the 4-position.	6.96	1	mononitrotoluene
fluorodifen fluorodifen: structure	2.13	1	aromatic ether
s-(2,4-dinitrophenyl)glutathione S-(2,4-dinitrophenyl)glutathione : A glutathione conjugate in which the thiol hydrogen of glutathione has been replaced by a 2,4-dinitrophenyl group.	2.06	1	glutathione conjugate
hexylglutathione S-hexylglutathione : An S-substituted glutathione that is glutathione in which the hydrogen of the thiol has been replaced by a hexyl group (PDB entry: 1PN9).	2	1	S-substituted glutathione
s-ethyl glutathione [no description available]	1.97	1	oligopeptide
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.42	2	cysteinium	fundamental metabolite

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