Page last updated: 2024-12-06

s-(2-chloroethyl)cysteine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

s-(2-chloroethyl)cysteine, also known as melphalan, is an alkylating agent used in chemotherapy to treat multiple myeloma, non-Hodgkin lymphoma, and ovarian cancer. It is synthesized through a multi-step process involving the reaction of cysteine with ethylene oxide followed by chlorination. Melphalan works by interfering with DNA replication and repair, ultimately leading to cell death. It is studied extensively due to its effectiveness in treating certain types of cancer, and ongoing research focuses on improving its efficacy and reducing its side effects.'

S-(2-chloroethyl)cysteine: induces nephrotoxicity; RN given refers to (L)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID34229
MeSH IDM0131778

Synonyms (15)

Synonym
s-(2-chloroethyl)-cysteine
s-(2-chloroethyl)cysteine
3-((2-chloroethyl)thio)alanine
alanine, 3-((2-chloroethyl)thio)-
brn 2433353
ccris 1745
s-(2-chloroethyl)-l-cysteine
nsc-241258
nsc241258
56674-34-1
2-amino-3-(2-chloroethylsulfanyl)propanoic acid
97142-17-1
s-(2-chloroethyl)-dl-cysteine
28361-96-8
DTXSID10914109
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.28 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]