RS 42358-197: a 5-hydroxytryptamine-3 receptor ligand; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 148209 |
| CHEMBL ID | 544784 |
| SCHEMBL ID | 305013 |
| MeSH ID | M0213479 |
| Synonym |
|---|
| rs-42358-197 |
| chembl544784 , |
| bdbm50000523 |
| 135729-55-4 |
| 1h-benz(de)isoquinolin-1-one, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,4,5,6-tetrahydro-, monohydrochloride, (s)- |
| (3h)-rs-42358-197 |
| rs 25259-007 |
| (s)-n-(1-azabicyclo(2.2.2)oct-3-yl)-2,4,5,6-tetrahydro-1h-benzo(de)isoquinolin-1-one hydrochloride |
| rs 42358-197 |
| unii-866e0t17rq |
| 866e0t17rq , |
| SCHEMBL305013 |
| DTXSID20159504 |
| 2-[(s)-1-azabicylco[2.2.2]oct-3-yl]-2,4,5,6-tetrahydro-1h-benz[de] isoquinolin-1-one hydrochloride |
| PEMWWRCTBNOHCX-UNTBIKODSA-N |
| 2-[(s)-1-azabicylco[2.2.2]oct-3-yl]-2,4,5,6-tetrahydro-1h-benz [de] isoquinolin-1-one hydrochloride |
| (s)-2-(quinuclidin-3-yl)-2,4,5,6-tetrahydro-1h-benzo[de]isoquinolin-1-one hcl |
| 2-((3s)-1-azabicyclo(2.2.2)oct-3-yl) 2,4,5,6-tetrahydro-1h-benzo(de)isoquinolin-1-one hydrochloride |
| 1h-benz(de)isoquinolin-1-one, 2-(3s)-1-azabicyclo(2.2.2)oct-3-yl-2,4,5,6-tetrahydro-, hydrochloride (1:1) |
| (2-((3s)-quinuclidin-3-yl)-2,4,5,6-tetrahydro-1h-benzo(de)isoquinolin-1-one hydrochloride) |
| dehydro palonosetron hydrochloride |
| (s)-2-(quinuclidin-3-yl)-2,4,5,6-tetrahydro-1h-benzo[de]isoquinolin-1-one hydrochloride |
| palonosetron-3-ene hydrochloride |
| 2-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-5,6-dihydro-4h-benzo[de]isoquinolin-1-one;hydrochloride |
| AKOS040744681 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID6310 | Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazine | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18 | 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists. |
| AID183147 | Potency to inhibit bradycardiac effect measured by Von Bezold-Jarisch assay in 9 anesthetized rats | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18 | 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||