Page last updated: 2024-12-11

rolodine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5359646
CHEMBL ID347425
SCHEMBL ID121916
MeSH IDM0577843

Synonyms (48)

Synonym
rolodine [usan:inn]
4-(benzylamino)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine
2-methyl-4-benzylaminopyrrolo(2,3-d)pyrimidine
rolodina [inn-spanish]
brn 0886046
nsc 106570
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 2-methyl-n-(phenylmethyl)-
rolodinum [inn-latin]
7h-pyrrolo(2,3-d)pyrimidine, 4-(benzylamino)-2-methyl-
2-methyl-4-benzylamino-pyrrolo-(2,3d)pyrimidine
7h-pyrrolo[2,3-d]pyrimidine, 4-(benzylamino)-2-methyl-
n-benzyl-n-(2-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amine
n-benzyl-2-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine
7h-pyrrolo[2,3-d]pyrimidin-4-amine, 2-methyl-n-(phenylmethyl)-
rolodine (usan)
D05750
7h-pyrrolo[2, 2-methyl-n-(phenylmethyl)-
4-(benzylamino)-2-methyl-7h-pyrrolo[2,3-d]pyrimidine
bw 58-271
nsc106570
mls000737264 ,
rolodine
wln: t56 bm gn inj fm1r& h1
rolodin
2-methyl-4-(benzylamino)-pyrrolo-[2,3d]pyrimidine
nsc-106570
7h-pyrrolo[2, 4-(benzylamino)-2-methyl-
1866-43-9
bw 58 271
bw 58271
smr000528492
CHEMBL347425
bw-58271
bw-58-271
NCGC00246715-01
626gmn0sto ,
rolodinum
unii-626gmn0sto
rolodina
HMS2886J03
SCHEMBL121916
rolodine [usan]
rolodine [inn]
2-dodecen-1-ylsuccinicanhydride
DTXSID30171919
2-methyl-4-benzylamino-pyrrolo-(2,3-d)pyrimidine
Q27263448
Z1317594904
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (7)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
TDP1 proteinHomo sapiens (human)Potency20.33750.000811.382244.6684AID686978; AID686979
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency79.43280.707936.904389.1251AID504333
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency32.64270.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency100.00003.548119.542744.6684AID743266
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency0.70790.050127.073689.1251AID588590
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency3.54810.00419.962528.1838AID2675
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID147707Concentration at which 50% of maximum response of callus yield derived from Nicotiana tabacum var is obtained1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
Quantitative aspects of the receptor binding of cytokinin agonists and antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.06 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]