retinoyl beta-glucuronide profile

retinoyl glucuronide: metabolite of retinoic acid in bile [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

9-cis-retinoyl-beta-D-glucuronide : A retinoid that is 9-cis-retinoic acid in which the carboxy proton has been replaced by a beta-D-glucuronyl group. It is a major metabolite of 9-cis-retinoic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5281877
CHEBI ID	28870
MeSH ID	M0087629

Synonym
retinoyl b-glucuronide
401-10-5
all-trans-retinoyl-beta-glucuronide
glucuronide
retinoyl glucuronide
o(15)-[(2s,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxytetrahydro-2h-pyran-2-yl]retinoic acid
CHEBI:28870
1-o-[(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]-beta-d-glucopyranuronic acid
all-trans-retinoyl-beta-d-glucuronide
9-cis-retinoyl-beta-d-glucuronide
retinoyl-beta-glucuronide
beta-d-glucopyranuronic acid, 1-retinoate
13-cis-retinoyl glucuronide
beta-d-glucopyranuronic acid, 1-ester with retinoic acid
retinoic acid beta-d-glucuronide
retinoyl beta-glucuronide
all-trans retinoyl \|a-d-glucuronide, >85% by hplc
(2s,3s,4s,5r,6s)-6-[(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
unii-xb6rq16y55
trans-retinoyl glucuronide
xb6rq16y55 ,
W-201374
13-cis-retinoyl b-d-glucuronide
9-cis-retinoyl b-d-glucuronide
W-203796
W-202656
e-retinoyl b-glucuronide
retinoyl .beta.-glucuronide
all-trans-retinoyl .beta.-d-glucuronide
glucopyranosiduronic acid, 1-retinoate, .beta.-d-
all-trans-retinoyl glucuronide
1004517-36-5
retinoyl glucuronide, all-trans
retinoic acid, 1-ester with glucopyranuronic acid
retinoic acid, .beta.-d-glucuronosyl ester
.beta.-d-glucopyranuronic acid, 1-retinoate
retinoic acid, 1-ester with .beta.-d-glucopyranosiduronic acid
(2s,3s,4s,5r,6s)-6-{[(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
DTXSID40274187
13-cis-retinoic acid acyl beta-d-glucuronide
13-cis-retinoic acid acyl beta-delta-glucuronide
13-cis-retinoyl-beta-d-glucuronide
all-trans-retinoyl-beta-delta-glucuronide
9-cis-retinoyl-beta-delta-glucuronide
13-cis-retinoyl-beta-delta-glucuronide
retinoic acid beta-delta-glucuronide
MTGFYEHKPMOVNE-NEFMKCFNSA-N
Q27103934
all-trans retinoyl beta-d-glucuronide, >85per cent by hplc
e-retinoylb-glucuronide
all-trans retinoyl ?-d-glucuronide, (>80%)
all-trans retinoyl ?-d-glucuronide
all-trans retinoyl ??-d-glucuronide
AKOS040754950

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
" Thereafter, RAG was eliminated through a first-order process, in accord with a typical two-compartment first order pharmacokinetic profile."	( Pharmacokinetic study of all-trans-retinoyl-beta-D-glucuronide in Sprague-Dawley rats after single and multiple intravenous administration(s). Barua, AB; Chan, SY; Ho, PC; Lin, HS; Low, KS; Olson, JA; Shoon, ML, 2001)	0.31

Dosage Studied

Excerpt	Relevance	Reference
"In order to compare the disposition and metabolism of 13-cis-retinoic acid (13-cis-RA) and all-trans-retinoic acid (all-trans-RA) in the nonpregnant female cynomolgus monkey, the plasma concentrations of the parent compound, the oxidized metabolites 4-oxo-13-cis-retinoic acid and 4-oxo-all-trans-retinoic acid, and the conjugate metabolites 13-cis-retinoyl-beta-glucuronide (13-cis-RAG) and all trans-retinoyl-beta-glucuronide (all-trans-RAG), were determined on day 1 and day 10 after oral dosing of 2 and 10 mg 13-cis- and all-trans-RA/kg/day."	( Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin. Bailey, JR; Fischer, B; Kraft, JC; Nau, H; Roberts, LG; Slikker, W; Wittfoht, W, )	0.13
" Since 13-cis-retinoyl-beta-glucuronide and 13-cis- and all-trans-retinoic acid were detected in the embryo after this multiple dosing schedule, any of the three or their combinations may have been involved in the induction of malformations, but all-trans-retinoic acid, a well-known potent teratogen detected at concentrations of between 590 and 80 ng/g for 10 critical hours during gestation, could have been the major component."	( Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity. Bochert, G; Chahoud, I; Creech Kraft, J; Eckhoff, C; Kochhar, DM; Nau, H, 1991)	0.28
"The liver and intestinal metabolites of orally dosed 13-cis-[11-3H]retinoic acid were analyzed in normal and 13-cis-retinoic acid treated rats 3 h after administration of the radiolabeled retinoid."	( 13-cis-retinoic acid metabolism in vivo. The major tissue metabolites in the rat have the all-trans configuration. Kroll, KD; McCormick, AM; Napoli, JL, 1983)	0.27
" In contrast, dosing with 13-cis-RA yielded much higher plasma retinoid levels."	( Metabolism of oral 9-cis-retinoic acid in the human. Identification of 9-cis-retinoyl-beta-glucuronide and 9-cis-4-oxo-retinoyl-beta-glucuronide as urinary metabolites. Masgrau, E; Nau, H; Sass, JO; Saurat, JH, 1995)	0.29
" Taken together, our findings that chronic dosing with RAG produces sustained levels of both the parent compound and the RA hydrolysis product, combined with the apparent low toxicity of RAG, suggest that RAG could be a safe and useful alternative to some retinoids which are presently being utilized in the clinic."	( Pharmacokinetics of chronically administered all-trans-retinoyl-beta-glucuronide in mice. Barua, AB; Connor, MJ; Olson, JA; Sawatsri, S; Sidell, N; Wada, RK, 2000)	0.31
" Therefore, long-term daily dosing of RAG seemed to decrease its distribution profile."	( Pharmacokinetic study of all-trans-retinoyl-beta-D-glucuronide in Sprague-Dawley rats after single and multiple intravenous administration(s). Barua, AB; Chan, SY; Ho, PC; Lin, HS; Low, KS; Olson, JA; Shoon, ML, 2001)	0.31
" In orally dosed rats (n = 6), neither RAG nor its products, except for occasional traces of the lactone, were detected."	( Pharmacokinetics of all-trans retinoyl beta-glucuronide in rats following intraperitoneal and oral administration. Barua, AB; Olson, JA; Romans, DA, 2003)	0.61
"1 mmol) was orally dosed to fasting well-nourished young men."	( Intestinal absorption and metabolism of retinoyl beta-glucuronide in humans, and of 15-[14C]-retinoyl beta-glucuronide in rats of different vitamin A status. Barua, AB; Goswami, BC; Ivanoff, KD; Olson, JA; Reida, AK, 2003)	0.59
" Blood was collected from the children in Group I (n 19) who were not dosed with RAG."	( A new approach to the assessment of marginal vitamin A deficiency in children in suburban Guwahati, India: hydrolysis of retinoyl glucuronide to retinoic acid. Barua, AB; Bhattacharjee, H; Gogoi, K; Goswami, BC; Sarma, PC, 2009)	0.35
" These included dose-response tests and isotope dilution assays."	( Vitamin A: biomarkers of nutrition for development. Tanumihardjo, SA, 2011)	0.37

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
glucuronic acids
retinoid	Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Retinol Metabolism	37	30
Vitamin A Deficiency	37	30

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	22 (34.38)	18.7374
1990's	28 (43.75)	18.2507
2000's	13 (20.31)	29.6817
2010's	1 (1.56)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (4.41%)	5.53%
Reviews	6 (8.82%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	59 (86.76%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	1.98	1	0	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.98	1	0	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
nitroblue tetrazolium Nitroblue Tetrazolium: Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.	1.97	1	0	organic cation
4-chlorophenylacetic acid 4-chlorophenylacetic acid: RN given refers to parent cpd. 4-chlorophenylacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-chlorophenyl group.	2.01	1	0	monocarboxylic acid; monochlorobenzenes	xenobiotic metabolite
tetrabutylammonium tetrabutylammonium: lipophilic probe; RN given refers to parent cpd	1.99	1	0	quaternary ammonium ion
uridine diphosphate glucuronic acid Uridine Diphosphate Glucuronic Acid: A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.. UDP-alpha-D-glucuronic acid : A UDP-sugar having alpha-D-glucuronic acid as the sugar component.	1.96	1	0	UDP-D-glucuronic acid	Escherichia coli metabolite; human metabolite; mouse metabolite
glucuronic acid Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.	1.94	1	0	D-glucuronic acid	algal metabolite
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	9.97	64	2	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
retinol Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.. vitamin A : Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.. all-trans-retinol : A retinol in which all four exocyclic double bonds have E- (trans-) geometry.. retinol : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).	6.53	20	0	retinol; vitamin A	human metabolite; mouse metabolite; plant metabolite
bromochloroacetic acid Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.	2	1	0	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound
retinaldehyde Retinaldehyde: A diterpene derived from the carotenoid VITAMIN A which functions as the active component of the visual cycle. It is the prosthetic group of RHODOPSIN (i.e., covalently bonded to ROD OPSIN as 11-cis-retinal). When stimulated by visible light, rhodopsin transforms this cis-isomer of retinal to the trans-isomer (11-trans-retinal). This transformation straightens-out the bend of the retinal molecule and causes a change in the shape of rhodopsin triggering the visual process. A series of energy-requiring enzyme-catalyzed reactions convert the 11-trans-retinal back to the cis-isomer.. all-trans-retinal : A retinal in which all four exocyclic double bonds have E- (trans-) geometry.	2.39	2	0	retinal; vitamin A	gap junctional intercellular communication inhibitor; human metabolite; mouse metabolite
retinol acetate retinol acetate: structure given in first source	1.97	1	0	acetate ester
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2	1	0	organic sodium salt	detergent; protein denaturant
beta carotene beta Carotene: A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).. provitamin A : A provitamin that can be converted into vitamin A by enzymes from animal tissues.	3.8	2	1	carotenoid beta-end derivative; cyclic carotene	antioxidant; biological pigment; cofactor; ferroptosis inhibitor; human metabolite; mouse metabolite; plant metabolite; provitamin A
lutein Lutein: A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.. xanthophyll : A subclass of carotenoids consisting of the oxygenated carotenes.	3.43	1	1	carotenol	food colouring; plant metabolite
etretinate retinoid : Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.	2.38	2	0	enoate ester; ethyl ester; retinoid	keratolytic drug
isotretinoin Isotretinoin: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.. isotretinoin : A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.	4.74	7	1	retinoic acid	antineoplastic agent; keratolytic drug; teratogenic agent
acitretin Acitretin: An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate.. acitretin : A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.	1.99	1	0	acitretin; alpha,beta-unsaturated monocarboxylic acid; retinoid	keratolytic drug
fenretinide Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.. 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.	3.48	2	0	monocarboxylic acid amide; retinoid	antineoplastic agent; antioxidant
retinamide retinamide: metabolite of tretinoin	1.97	1	0
methyl retinoate methyl retinoate: RN given refers to cpd without isomeric designation	1.94	1	0
vitamin a2 vitamin A2: RN given refers to cpd without isomeric designation. all-trans-3,4-didehydroretinol : A retinoid derived from 3,4-desaturation of the beta-ionone ring of all-trans-retinol.	1.98	1	0	retinoid; vitamin A	human xenobiotic metabolite; marine xenobiotic metabolite; mouse metabolite
4-oxoretinoic acid 4-oxoretinoic acid: RN given refers to cpd without isomeric designation; structure. all-trans-4-oxoretinoic acid : A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring.	2.67	3	0	enone; retinoid	human xenobiotic metabolite
5,6-epoxyretinoic acid 5,6-epoxyretinoic acid: RN given refers to parent cpd without isomeric designation. 5,6-epoxyretinoic acid : A retinoid obtained by epoxidation across the 5,6-double bond of retinoic acid.	2.36	2	0
alcian blue Alcian Blue: A copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.	1.99	1	0

Condition	Relationship Strength	Studies	Trials
Deficiency, Vitamin A [description not available]	5.98	10	1
Vitamin A Deficiency A nutritional condition produced by a deficiency of VITAMIN A in the diet, characterized by NIGHT BLINDNESS and other ocular manifestations such as dryness of the conjunctiva and later of the cornea (XEROPHTHALMIA). Vitamin A deficiency is a very common problem worldwide, particularly in developing countries as a consequence of famine or shortages of vitamin A-rich foods. In the United States it is found among the urban poor, the elderly, alcoholics, and patients with malabsorption. (From Cecil Textbook of Medicine, 19th ed, p1179)	10.98	10	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	9.61	10	0
Night Blindness Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)	2.98	1	0
Birth Weight The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.	2.01	1	0
Bronchial Pneumonia [description not available]	2.01	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.01	1	0
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	3.34	2	0
Vaginal Diseases Pathological processes of the VAGINA.	1.96	1	0
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	4	5	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	1.99	1	0
Weight Gain Increase in BODY WEIGHT over existing weight.	2	1	0
Acute Myelogenous Leukemia [description not available]	2.37	2	0
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.37	2	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.97	1	0

retinoyl beta-glucuronide

Description

Cross-References

Synonyms (54)

Research Excerpts

Pharmacokinetics

Dosage Studied

Roles (1)

Drug Classes (2)

Pathways (2)

Research

Studies (64)

Market Indicators

Research Demand Index: 9.91

Study Types

retinoyl beta-glucuronide

Description

Cross-References

Synonyms (54)

Research Excerpts

Pharmacokinetics

Dosage Studied

Roles (1)

Drug Classes (2)

Pathways (2)

Research

Studies (64)

Market Indicators

Research Demand Index: 9.91

Study Types

Related Drugs (25)

Related Conditions (15)