Compounds > rasfonin
Page last updated: 2024-10-14

rasfonin

Description

rasfonin: an apoptosis inhibitor; isolated from Talaromyces; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11259090
MeSH IDM0374519

Synonyms (10)

Synonym
rasfonin
(a?-rasfonin
(2e,4e,6s)-8-hydroxy-6-(hydroxymethyl)-4-methyl-2,4-octadienoic acid, (2r,3r)-3,6-dihydro-6-oxo-2-[(1s,3r,5e)-1,3,5-trimethyl-5-hepten-1-yl]-2h-pyran-3-yl ester
303156-68-5
(-)-rasfonin
[(2r,3r)-2-[(e,2s,4r)-4,6-dimethyloct-6-en-2-yl]-6-oxo-2,3-dihydropyran-3-yl] (2e,4e,6s)-8-hydroxy-6-(hydroxymethyl)-4-methylocta-2,4-dienoate
CS-0082478
HY-121532
DTXSID301043830
AKOS040756192

Research Excerpts

Overview

Rasfonin is a novel 2-pyrone derivative reported to induce apoptosis in ras-dependent cells. It is a fungal secondary metabolite with demonstrated antitumor effects.

ExcerptReference
"Rasfonin is a novel 2-pyrone derivative reported to induce apoptosis in ras-dependent cells. "( Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Che, Y; Cheng, J; Li, L; Li, Y; Liu, F; Xiao, Z; Zhang, Y; Zheng, P; Zhou, W, 2014)
"Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. "( Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells.
Che, Y; Jiang, X; Li, Y; Lu, Q; Sun, H; Wang, W; Xi, Z; Yan, S; Yang, X, 2015)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.1510metal allergen;
nickel group element atom;
platinum group metal atom
zirconium
Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.		2.1510titanium group element atom
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma Of Kidney
[description not available]		02.5720
Cancer of Kidney
[description not available]		02.5720
Carcinoma, Renal Cell
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.		02.5720
Kidney Neoplasms
Tumors or cancers of the KIDNEY.		02.5720
Bone Cancer
[description not available]		02.2110
Osteogenic Sarcoma
[description not available]		02.2110
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES.		02.2110
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)		07.2110
Cancer of Pancreas
[description not available]		02.110
Invasiveness, Neoplasm
[description not available]		02.110
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.110