Compounds > pyrromethene 546
Page last updated: 2024-11-12

pyrromethene 546

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pyrromethene 546: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14766991
CHEMBL ID3794349
SCHEMBL ID14020660
MeSH IDM0489972

Synonyms (28)

Synonym
pyrromethene 546
121207-31-6
4,4-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene
SCHEMBL14020660
[[(3,5-dimethyl-1h-pyrrol-2-yl)(3,5-dimethyl-2h-pyrrol-2-ylidene)methyl]methane](difluoroborane)
D4341
DTXSID50563812
{2-[1-(3,5-dimethyl-2h-pyrrol-2-ylidene-kappan)ethyl]-3,5-dimethyl-1h-pyrrolato-kappan}(difluoro)boron
CHEMBL3794349
AS-71734
2,2-difluoro-4,6,8,10,12-pentamethyl-1??,3-diaza-2-boratricyclo[7.3.0.0(3),?]dodeca-1(12),4,6,8,10-pentaen-1-ylium-2-uide
mfcd00467372
5,5-difluoro-1,3,7,9,10-pentamethyl-5h-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
FT-0701408
ylidene)methyl]methane](difluoroborane)
[[(3,5-dimethyl-1h-pyrrol-2-yl)(3,5-dimethyl-2h-pyrrol-2-
2,2-difluoro-4,6,8,10,12-pentamethyl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaene
5,5-difluoro-1,3,7,9,10-pentamethyl-5h-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine
bdp 493/503 lipid stain
AMY3546
T70146
YSZC157
AKOS037646964
R12-0001
D5724
[[(3,5-dimethyl-1h-pyrrol-2-yl)(3,5-dimethyl-2h-pyrrol-2-ylidene)methyl]methane](difluoroborane) (purified by sublimation)
SY056362
5,5-difluoro-1,3,7,9,10-pentamethyl-5h-dipyrrolo[1,2-c:2 inverted exclamation mark ,1 inverted exclamation mark -f][1,3,2]diazaborinin-4-ium-5-uide

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" DPH, Nile Red, and BODIPY 493/503 were compared as assay reagents in oleic acid dose-response experiments."( High-content imaging of neutral lipid droplets with 1,6-diphenylhexatriene.
Gabrielli, BG; Gonda, TJ; Ranall, MV, 2011)		0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1293504Drug uptake in Chlamydia trachomatis serovar LGV-L2 inclusion infected in human HeLa cells at 1 uM after 48 hrs by laser confocal microscopy2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.
AID1293505Drug uptake in human HeLa cells infected with Chlamydia trachomatis serovar LGV-L2 at 1 uM after 48 hrs by laser confocal microscopy2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (20.00)29.6817
2010's12 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.59 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational1 (6.67%)0.25%
Other14 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
porphobilinogen
[no description available]		2.4520aralkylamino compound;
dicarboxylic acid;
pyrroles		Escherichia coli metabolite;
metabolite;
mouse metabolite
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.2110aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.1310dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
c.i. 42510
Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.. basic fuchsin : A four-component mixture of chemically related dyes comprising pararosanilin, rosanilin, magenta II and new fuchsin in varying amounts. rosanilin : A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the major constituents of Basic fuchsin, together with pararosanilin, magenta II and new fuchsin.		2.110
l 451167
L 451167: structure given in first source		2.110
nile red
nile red : An organic heterotetracyclic compound that is 5H-benzo[a]phenoxazin-5-one substituted at position 9 by a diethylamino group.		2.4520aromatic amine;
cyclic ketone;
organic heterotetracyclic compound;
tertiary amino compound		fluorochrome;
histological dye
diphenylhexatriene
Diphenylhexatriene: A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.		2.0610alkatrienefluorochrome
pyrromethene 597
pyrromethene 597: structure in first source		2.0210
oligonucleotides
[no description available]		2.110
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.110chlorophyll;
methyl ester		cofactor
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
[no description available]		2.4920BODIPY compound
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		2.0510
pheophytin a
pheophytin a: structure given in first source; RN given refers to (3S-(3alpha(2E,7S*,11S*),4beta,21beta))-isomer		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Chlamydia
[description not available]		02.1310
Chlamydia Infections
Infections with bacteria of the genus CHLAMYDIA.		02.1310
Anasarca
[description not available]		02.110
Petechiae
Pinhead size (3 mm) skin discolorization due to hemorrhage.		02.110
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.110
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.		02.110
Purpura
Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is		02.110