pyridoxal 5'-diphospho-5'-adenosine profile

Pyridoxal 5'-diphospho-5'-adenosine (PLP-Ado) is a coenzyme formed from the reaction of pyridoxal 5'-phosphate (PLP) with adenosine 5'-triphosphate (ATP). It acts as a cofactor for a wide range of enzymatic reactions, particularly those involving amino acid metabolism. PLP-Ado plays a crucial role in the synthesis of neurotransmitters, such as dopamine, serotonin, and norepinephrine, which are essential for brain function and mood regulation. Its importance in these processes makes it a target for research in neurological disorders, such as Parkinson's disease and Alzheimer's disease. PLP-Ado also participates in the synthesis of heme, a component of hemoglobin, which is responsible for oxygen transport in the blood. The study of PLP-Ado aims to understand its role in various metabolic pathways, its contribution to human health, and its potential as a therapeutic target for various diseases.'

pyridoxal 5'-diphospho-5'-adenosine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	121867
MeSH ID	M0138895

Synonym
adenosine diphosphopyridoxal
4500-99-6
[[(2r,3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl hydrogen phosphate
5'-adenosine-5'-diphosphopyridoxal
adp-pyridoxal
unii-il00v5z57e
ap2pl
adenosine 5'-(trihydrogen diphosphate), p'-((4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl) ester
pyridoxal 5'-diphospho-5'-adenosine
il00v5z57e ,
pyridoxal-adenine dinucleotide
9-{5-o-[({[(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]pentofuranosyl}-9h-purin-6-amine
DTXSID20963320
Q27280773

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (32.00)	18.7374
1990's	15 (60.00)	18.2507
2000's	2 (8.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (96.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetyl phosphate acetyl dihydrogen phosphate : An acyl monophosphate in which the acyl group specified is acetyl.	1.99	1	acyl monophosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
pyridoxal [no description available]	2.89	4	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
pyridoxal phosphate Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).. pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.	10.64	25	methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6 phosphate	coenzyme; cofactor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	3.92	13	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	5.64	25	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	3.49	2	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
adenosine monophosphate Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.	1.97	1	adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
uridine diphosphate glucose Uridine Diphosphate Glucose: A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.. UDP-alpha-D-glucose : The alpha-anomer of UDP-alpha-D-glucose. It is used in nucleotide sugars metabolism.	3.08	1	UDP-D-glucose	fundamental metabolite
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.4	2	fluorescein isothiocyanate
uridine diphosphopyridoxal uridine diphosphopyridoxal: structure given in first source	3.49	2
adenosine triphosphopyridoxal adenosine triphosphopyridoxal: RN given from first source	2.66	3
adenosine tetraphosphopyridoxal adenosine tetraphosphopyridoxal: RN given from first source	2.37	2
3'-anthraniloyl-2'-deoxy-atp [no description available]	1.98	1
nadp [no description available]	6.97	1
sodium borohydride sodium borohydride: RN given refers to parent cpd	1.97	1	inorganic sodium salt; metal tetrahydridoborate
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	1.96	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite

pyridoxal 5'-diphospho-5'-adenosine

Description

Cross-References

Synonyms (14)

Research

Studies (25)

Market Indicators

Research Demand Index: 11.11

Study Types