pyragonicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pyragonicin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10393745
CHEMBL ID	448093
MeSH ID	M0496640

Synonyms (3)

Synonym
CHEMBL448093
pyragonicin
(2s)-2-methyl-4-[(2r,8r,11r)-2,8,11-trihydroxy-11-[(2r,5r,6r)-5-hydroxy-6-tetradecyloxan-2-yl]undecyl]-2h-furan-5-one

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID379112	Cytotoxicity against human MIA PaCa2 cells	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
AID379124	Cytotoxicity against human HT-29 cells	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
AID379125	Cytotoxicity against human A-498 cells	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
AID379121	Toxicity in brine shrimp	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
AID379111	Cytotoxicity against human PC-3 cells	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
AID379123	Cytotoxicity against human MCF7 cells	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
AID379122	Cytotoxicity against human A549 cells	1999	Journal of natural products, Mar, Volume: 62, Issue:3	Annonaceous acetogenins: recent progress.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.03 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.82 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
bendiocarb bendiocarb: FICAM 80W contains 80% of the above chemical cpd as the active ingredient	3.1	1	benzodioxoles; carbamate ester	agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	3.1	1	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
cypermethrin cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.	3.1	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound	agrochemical; molluscicide; pyrethroid ester acaricide; pyrethroid ester insecticide
propoxur Propoxur: A carbamate insecticide.. propoxur : A carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group.	3.1	1	aromatic ether; carbamate ester	acaricide; agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	2.03	1	butan-4-olide	metabolite; neurotoxin
butenolide butenolide: inhibits experimental allergic encephalomyelitis in rats. butenolide : A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.	2.03	1	butenolide
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.03	1	elemental platinum; nickel group element atom; platinum group metal atom
acetogenins Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.	7.72	3
hydramethylnon hydramethylnon: used as fire ant insecticide in southern USA; poorly absorbed by mammals & more than 95% is excreted unchanged in the feces. hydramethylnon : A member of the class of hydrazones that is used as an insecticide for control of ants and cockroaches.	3.1	1	hydramethylnon
pyranicin pyranicin: structure in first source	8.51	2
10-hydroxyasimicin 10-hydroxyasimicin: a bis-tetrahydrofuran acetogenin with 4 hydroxyl groups; from Asimina triloba; structure given in first source	3.1	1

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