purealin: from sea sponge Psammaplysilla purea; modulates ATPase activity of dephosphorylated myosin; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6419303 |
| MeSH ID | M0143403 |
| Synonym |
|---|
| purealin |
| (5r,6s)-n-[3-[4-[(2z)-3-[2-(2-amino-1h-imidazol-5-yl)ethylamino]-2-hydroxyimino-3-oxopropyl]-2,6-dibromophenoxy]propyl]-7,9-dibromo-6-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,7,9-triene-3-carboxamide |
Purealin is a small bioactive compound obtained from the marine sponge.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Purealin is a small bioactive compound obtained from the marine sponge. " | ( Unfolding of the myosin head by purealin in glycerol. Kobayashi, J; Nakamura, M; Nonomura, Y; Ohizumi, Y; Takito, J, 2018) | 2.21 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID261869 | Antiproliferative activity against human PC3 prostate carcinoma cells by MTS assay | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6 | Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. |
| AID261866 | Antiproliferative activity against human 2008 ovarian carcinoma cells by MTS assay | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6 | Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. |
| AID261865 | Inhibition of MT-stimulated ATPase activity of rat cytoplasmic dynein heavy chain motor domain | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6 | Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. |
| AID261870 | Antiproliferative activity against mouse L1210 leukemia cell line by MTS assay | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6 | Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. |
| AID261867 | Antiproliferative activity against human MDA-MB-231 breast carcinoma cells by MTS assay | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6 | Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. |
| AID261868 | Antiproliferative activity against human HT29 colon carcinoma cells by MTS assay | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6 | Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.29) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||