Ponceau 3R is a synthetic azo dye. It is derived from naphthalene and contains two sulfonic acid groups. The dye is bright red in color and is used in a variety of applications, including food coloring, textiles, and cosmetics. Ponceau 3R is considered safe for use in food products in many countries. Ponceau 3R can be synthesized via a multi-step process. The first step involves the diazotization of 1-naphthylamine with sodium nitrite and hydrochloric acid. The diazonium salt is then coupled with 2-naphthol, yielding Ponceau 3R. Despite being commonly used in food products, there have been some studies suggesting that Ponceau 3R may be a possible carcinogen. Further research is needed to confirm these findings. The dye has been found to induce hyperactivity in children, but there is no consensus on this finding. Ponceau 3R is often studied because it is a common food additive and has been linked to potential health risks. This dye is also used as a coloring agent in some pharmaceuticals. Research on Ponceau 3R often focuses on its safety and potential health effects. The dye's potential genotoxicity is being investigated to determine if it poses a carcinogenic risk. The potential for Ponceau 3R to cause allergic reactions is also under investigation. '
ponceau 3R: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 19095 |
| CHEMBL ID | 3186386 |
| CHEBI ID | 176136 |
| SCHEMBL ID | 3624402 |
| SCHEMBL ID | 1268489 |
| SCHEMBL ID | 1268487 |
| MeSH ID | M0074226 |
| Synonym |
|---|
| disodium;3-hydroxy-4-[(2,4,5-trimethylphenyl)diazenyl]naphthalene-2,7-disulonate |
| CHEBI:176136 |
| disodium 3-hydroxy-4-[(e)-(2,4,5-trimethylphenyl)diazenyl]naphthalene-2,7-disulfonate |
| c.i.16155 |
| fd & c red no. 1 |
| usacert red no. 1 |
| maple ponceau 3r |
| a.f. red no. 1 |
| c.i. food red 6 |
| food red 6 |
| ext d and c red no. 15 |
| c.i. food red 6, disodium salt |
| 3564-09-8 |
| nsc-10461 |
| ponceau 3r lake |
| nsc10461 |
| ponceau 3r |
| ponceau rn |
| fdc red 1 |
| ponceau 3rn |
| dolkwal ponceau 3r |
| d and c red 15 |
| ponceau 3r sodium salt |
| nsc 10461 |
| einecs 222-638-0 |
| disodium 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)naphthalene-2,7-disulphonate |
| 3-hydroxy-4((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulfonic |
| ccris 527 |
| cerven kumidinova [czech] |
| 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulfonic acid disodium salt |
| 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulphonic acid, disodium salt |
| cerven potravinarska 6 [czech] |
| disodium 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulphonate |
| sodium cumeneazo-beta-naphthol disulphonate |
| disodium 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulfonate |
| sodium cumeneazo-beta-naphtholdisulphonate |
| 2,7-naphthalenedisulfonic acid, 3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-, disodium salt |
| hsdb 2946 |
| ci 16155 |
| af red no. 1 |
| sodium cumeneazo-beta-naphthol disulfonate |
| ci food 6 |
| ci food red 6, disodium salt |
| SCHEMBL3624402 |
| dtxcid801231 |
| tox21_202788 |
| NCGC00260334-01 |
| cas-3564-09-8 |
| dtxsid7021231 , |
| cerven kumidinova |
| unii-fa32r9s74x |
| fa32r9s74x , |
| cerven potravinarska 6 |
| FT-0634904 |
| ponceau 3r [iarc] |
| aka502 |
| ponceau 3r [ii] |
| c.i. food red 6 disodium salt |
| ponceau 3r [hsdb] |
| fd&c red no. 1 (delisted) |
| red no. 502 |
| ponceau 3r [mi] |
| aka502 [inci] |
| 2,7-naphthalenedisulfonic acid, 3-hydroxy-4-(2-(2,4,5-trimethylphenyl)diazenyl)-, sodium salt (1:2) |
| SCHEMBL1268489 |
| SCHEMBL1268487 |
| ponceau3r |
| CHEMBL3186386 |
| ponceau 3r, analytical standard |
| pon-ceau 3r |
| sodium (e)-3-hydroxy-4-((2,4,5-trimethylphenyl)diazenyl)naphthalene-2,7-disulfonate |
| allylorthoformate |
| disodium 3-hydroxy-4-[(2,4,5-trimethylphenyl)azo]-2,7-naphthalenedisulfonate |
| STARBLD0009511 |
| disodium;3-hydroxy-4-[(2,4,5-trimethylphenyl)diazenyl]naphthalene-2,7-disulfonate |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| progesterone receptor | Homo sapiens (human) | Potency | 0.1208 | 0.0004 | 17.9460 | 75.1148 | AID1346784 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.9593 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.5441 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.98) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||