Page last updated: 2024-12-08

podophyllic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

podophyllic acid: natural product with antitumor effect [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID134632
CHEMBL ID32955
SCHEMBL ID8016
MeSH IDM0494593

Synonyms (12)

Synonym
1853-37-8
podophyllic acid
diaethyl-(2-chlor-1-(2,4-dichlorphenyl))-vinyl-phosphat [german]
podophyllinic acid
CHEMBL32955
(5r,6r,7r,8r)-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole-6-carboxylic acid
unii-16fk9l3306
diaethyl-(2-chlor-1-(2,4-dichlorphenyl))-vinyl-phosphat
16fk9l3306 ,
naphtho(2,3-d)-1,3-dioxole-6-carboxylic acid, 5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, (5r,6r,7r,8r)-
SCHEMBL8016
Q27251810

Research Excerpts

Effects

ExcerptReferenceRelevance
"Podophyllic acid has antitumor effect, but the change of structure affects the function of derivatives of podophylloxin greatly."( [An experimental study on proliferative effects and apoptotic effects of podophyllic acid in K562 cells].
Chen, C; Gao, P; Jia, Z; Yu, J, 2005
)
2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID46279In vitro cytotoxicity against human colon cancer COLO 205 cell line1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
AID80250In vitro cytotoxicity against human colon cancer HCT 116 cell line1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
AID85442In vitro cytotoxicity against human colon cancer HT 29 cell line1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
AID80367In vitro cytotoxicity against human colon cancer HCT 15 cell line1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
AID79771In vitro cytotoxicity against human colon cancer HCC 2998 cell line1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
AID94686In vitro cytotoxicity against human colon cancer KM 12 cell line1998Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11
Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (41.67)18.7374
1990's1 (8.33)18.2507
2000's4 (33.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.39 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]