Page last updated: 2024-12-08

pneumadin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pneumadin: lung peptide which triggers antidiuresis; the rat peptide begins with Tyr and the peptide from human fetal lungs has Ala instead of Tyr [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID164313
MeSH IDM0183593

Synonyms (8)

Synonym
130918-90-0
pneumadin
tyr-gly-glu-pro-lys-leu-asp-ala-gly-val-nh2
pnemadin (rat)
pneumadin (rat)
(s)-4-(2-((s)-2-amino-3-(4-hydroxyphenyl)propanamido)acetamido)-5-((s)-2-(((3s,9s,12s,15s,18s)-22-amino-3-carbamoyl-12-(carboxymethyl)-15-isobutyl-2,9-dimethyl-5,8,11,14,17-pentaoxo-4,7,10,13,16-pentaazadocosan-18-yl)carbamoyl)pyrrolidin-1-yl)-5-oxopentan
pneumadin(rat)
AKOS040742428

Research Excerpts

Overview

Pneumadin (PNM) is a decapeptide originally isolated from mammalian lungs. It exerts a potent antidiuretic action by stimulating arginine-vasopressin release. Pneumadin has previously been found to enhanced rat adrenal growth.

ExcerptReferenceRelevance
"Pneumadin (PNM) is a decapeptide, originally isolated from mammalian lungs, which exerts a potent stimulating effect on arginine-vasopressin (AVP) release, thereby evoking an antidiuretic effect. "( Tissue distribution of pneumadin immunoreactivity in the rat.
Konwerska, A; Kosowicz, J; Malendowicz, LK; Miskowiak, B; Nussdorfer, GG; Tortorella, C, 2003
)
2.07
"Pneumadin (PNM) is a decapeptide (the rat peptide: Tyr-Gly-Glu-Pro-Lys-Leu-Asp-Ala-Gly-Val-NH2) isolated from mammalian lungs. "( Pneumadin in the ventral prostate and seminal vesicles of estradiol-treated rats: RIA and immunocytochemical studies.
Konwerska, A; Kosowicz, J; Malendowicz, LK; Miśkowiak, B; Nussdorfer, GG; Ziółkowska, A, 2003
)
3.2
"Pneumadin (PNM) is a decapeptide originally isolated from mammalian lungs, and exerts a potent antidiuretic action by stimulating arginine-vasopressin release. "( Pneumadin in the rat ventral prostate and its hormonal regulation.
Belloni, AS; Konwerska, A; Kosowicz, J; Malendowicz, LK; Miskowiak, B; Nussdorfer, GG, 2004
)
3.21
"Pneumadin is an antidiuretic decapeptide, recently isolated from rat and human lung. "( The antidiuretic effect of pneumadin requires a functional arginine vasopressin system.
Flynn, TG; Jennings, DB; Lawson, B; Pang, SC; Sarda, IR; Watson, JD; Wigle, DA, 1995
)
2.03
"Pneumadin (PNM) is a biologically active decapeptide, originally isolated from mammalian lungs, that has been previously found to acutely stimulate pituitary-adrenocortical axis in rats. "( Effects of pneumadin (PNM) on the adrenal glands. 5. Potent stimulating action of PNM on adrenocortical growth of dexamethasone-administered rats.
Macchi, C; Malendowicz, LK; Markowska, A; Nussdorfer, GG, 1996
)
2.13
"Pneumadin (PNM) is a biologically active decapeptide, which has previously been found to enhanced rat adrenal growth; the mechanism is indirect and probably involves the stimulation of both arginine-vasopressin (AVP) and ACTH release. "( Effects of pneumadin (PNM) on the adrenal glands. 6. Further studies on the inhibitory effect of PNM on dexamethasone-induced atrophy of the rat adrenal cortex.
Andreis, PG; Malendowicz, LK; Markowska, A; Miskowiak, B; Nussdorfer, GG, 1997
)
2.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.01 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]