Compounds > plukenetione a
Page last updated: 2024-11-13

plukenetione a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

plukenetione A: produced by honey bees from various plant sources; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44589660
CHEMBL ID485750
MeSH IDM0528250

Synonyms (3)

Synonym
plukenetione a
CHEMBL485750
bdbm50479806
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (39)

Assay IDTitleYearJournalArticle
AID345175Inhibition of Moloney murine leukemia virus reverse transcriptase2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345172Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA up to 6.25 ug/mL after 30 mins by agarose gel electrophoresis2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID1228172Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.
AID345179Decrease in multidrug-resistant related protein gene expression in human HCT8 cells at 2.5 times IC50 after 24 hrs by RT-PCR2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345171Induction of late apoptosis in [14C]D-thymidine labeled human HCT8 cells assessed DNA fragmentation treated at 10 times IC50 for 8 hrs measured after 24 hrs by liquid scintillation counter2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345150Cytotoxicity against cisplatin-resistant human A2780 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345145Cytotoxicity against human MCF7 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345159Cytotoxicity against etoposide-resistant human LNCAP cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345148Cytotoxicity against human A2780 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345170Induction of late apoptosis in [14C]D-thymidine labeled human HCT8 cells assessed DNA fragmentation treated at 2.5 times IC50 for 8 hrs measured after 24 hrs by liquid scintillation counter2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345147Cytotoxicity against 5-FU-resistant human MCF7 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345168Cell cycle arrest in human HCT8 cells assessed as accumulation at S phase at IC50 after 24 hrs by FACS analysis relative to control2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345163Cytotoxicity against HEK293 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345158Cytotoxicity against human LNCAP cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345149Cytotoxicity against doxorubicin-resistant human A2780 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345143Cytotoxicity against SN38-resistant human HCT8 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345169Cell cycle arrest in human HCT8 cells assessed as accumulation at G2/M phase at IC50 after 24 hrs by FACS analysis relative to control2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID1228175Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.
AID345177Decrease in topoisomerase 2 beta gene expression in human HCT8 cells at 2.5 times IC50 after 24 hrs by RT-PCR2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345140Cytotoxicity against 5-FU-resistant human HT-29 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345162Cytotoxicity against human H460 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345167Cell cycle arrest in human HCT8 cells assessed as accumulation at G0/G1 phase at IC50 after 24 hrs by FACS analysis relative to control2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345139Cytotoxicity against human HT-29 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345142Cytotoxicity against human HCT8 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345173Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA up to 12.5 ug/mL after 30 mins by agarose gel electrophoresis2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345174Inhibition of Taq DNA polymerase2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345151Cytotoxicity against human M51 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345144Cytotoxicity against raltitrexed-resistant human HCT8 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345164Cytotoxicity against human MCR5 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345420Cytotoxicity against human Jurkat cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345141Cytotoxicity against SN38-resistant human HT-29 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345146Cytotoxicity against doxorubicin-resistant human MCF7 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID345178Decrease in EGF receptor gene expression in human HCT8 cells at 2.5 times IC50 after 24 hrs by RT-PCR2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID1228171Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.
AID345165Cytotoxicity against Swiss mouse 3T3 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID1228173Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.
AID345152Cytotoxicity against cisplatin-resistant human M51 cells after 24 hrs2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
AID1228174Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.
AID345176Inhibition of HIV reverse transcriptase2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phloroglucinol
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.		2.0410benzenetriol;
phenolic donor		algal metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0410nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
nonane
iotrochotin: toxin from the Caribbean sponge Iotrochota birotulata, which selectively permeabilizes synaptosomes. nonane : A straight chain alkane composed of 9 carbon atoms.		2.0410alkaneplant metabolite;
volatile oil component
adamantane
Adamantane: A tricyclo bridged hydrocarbon.		2.0410adamantanes;
polycyclic alkane
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
hyperforin
hyperforin: a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure;. hyperforin : A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.		2.1110
mucronulatol
mucronulatol: compound from Caribbean propolis that exerts cytotoxic effects on human tumor cell lines. mucronulatol : A methoxyisoflavan that is (S)-isoflavan substituted by methoxy groups at positions 2' and 4' and hydroxy groups at positions 7 and 3' respectively.		2.0410hydroxyisoflavans;
methoxyisoflavan		antineoplastic agent;
plant metabolite
nemorosone
[no description available]		7.4520
ConditionIndicatedRelationship StrengthStudiesTrials