Compounds > piperidine-4-carboxamide
Page last updated: 2024-12-05

piperidine-4-carboxamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Piperidine-4-carboxamide is a heterocyclic compound that serves as a building block for various pharmaceuticals and bioactive molecules. Its synthesis typically involves reactions like amination or amidation of piperidine-4-carboxylic acid. Research on this compound focuses on its potential therapeutic applications due to its ability to interact with receptors and enzymes relevant to various diseases. For instance, derivatives of piperidine-4-carboxamide have shown promise as anti-inflammatory agents, anticonvulsants, and even as potential treatments for Alzheimer's disease. Its structural flexibility allows for modifications to fine-tune its pharmacological properties, making it an attractive target for medicinal chemistry studies.'

piperidine-4-carboxamide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3772
CHEBI ID166563
SCHEMBL ID12461666
SCHEMBL ID1298
MeSH IDM000610621

Synonyms (52)

Synonym
AC-539
BB 0256894
CHEBI:166563
4-piperidine carboxamide
nsc82318
nsc-82318
39546-32-2
isonipecotamide ,
4-piperidinecarboxamide
hexahydroisonicotinamide
piperidine-4-carboxamide
4-piperidinecarboxamide, 97%
I0255
AKOS000119354
A6617
piperidine-4-carboxylic acid amide
piperidine-4-carboxylicacidamide
unii-cze2810t4x
nsc 82318
einecs 254-501-6
cze2810t4x ,
BP-11768
FT-0627432
AM20100043
PB25917
SCHEMBL12461666
iso-nipecotamide
piperidin-4-carboxylic amide
4-aminocarbonylpiperidine
isonipecotic acid amide
4-piperidine-carboxamide
4-carbamoylpiperidine
SCHEMBL1298
DTXSID7068182
TS-01685
STR01101
1219803-20-9
4-piperidine-d9-carboxamide
W-111734
mfcd00038012
F2190-0334
CS-W013464
BCP18799
4-(aminocarbonyl)piperidine
4-piperidylcarboxamide
4-carboxamidopiperidine
Q63392690
EN300-20201
STL183252
SY005311
V5Y ,
piperidine-4-carboxiamide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
piperidinecarboxamide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.30 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.30)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrrolidonecarboxylic acid
Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.		2.31105-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.1310prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
piperidines
Piperidines: A family of hexahydropyridines.		3.4460
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia
[description not available]		02.7220
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.7220
Dementia Praecox
[description not available]		02.2510
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.		02.2510
Adjuvant Arthritis
[description not available]		02.1310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1310
Pyrexia
[description not available]		02.1310
Innate Inflammatory Response
[description not available]		02.1310
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process.		02.1310
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.1310