picrolonic acid: common lab reagent for alkaloids, amino acids & calcium; found mutagenic for Salmonella typhimurium; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 68369 |
| CHEMBL ID | 1354731 |
| SCHEMBL ID | 1934404 |
| MeSH ID | M0055681 |
| Synonym |
|---|
| 550-74-3 |
| nsc5049 |
| 3h-pyrazol-3-one,4-dihydro-5-methyl-4-nitro-2-(4-nitrophenyl)- |
| picrolonic acid |
| 3h-pyrazol-3-one, 1,4-dihydro-5-methyl-4-nitro-2-(4-nitrophenyl)- |
| picrolonic acid (van) |
| 3-methyl-4-nitro-1-p-nitrophenyl-5-pyrazolone |
| 2-pyrazolin-5-one, 3-methyl-4-nitro-1-(p-nitrophenyl)- |
| brn 0623723 |
| nsc 5049 |
| 3h-pyrazol-3-one, 2,4-dihydro-5-methyl-4-nitro-2-(4-nitrophenyl)- |
| 3-methyl-4-nitro-1-(p-nitrophenyl)-2-pyrazolin-5-one |
| einecs 208-986-6 |
| SR-01000632267-1 |
| MAYBRIDGE1_004192 |
| NCGC00160171-01 |
| HMS553G14 |
| 5-methyl-4-nitro-2-(4-nitrophenyl)-4h-pyrazol-3-one |
| unii-aw40r29u5b |
| P0429 |
| CCG-42254 |
| FT-0632370 |
| AKOS015903060 |
| SCHEMBL1934404 |
| 3-methyl-4-nitro-1-(4-nitrophenyl)-1h-pyrazol-5(4h)-one |
| CHEMBL1354731 |
| 5-methyl-4-nitro-2-(4-nitrophenyl)-2,4-dihydro-3h-pyrazol-3-one # |
| OVFUUSPKWADLNJ-UHFFFAOYSA-N |
| picrolonic acid, 97% |
| pikrolonsaure |
| DTXSID50862175 |
| picrolonicacid |
| VS-13455 |
| 3-methyl-4-nitro-1-(4-nitrophenyl)-4,5-dihydro-1h-pyrazol-5-one |
| STL558974 |
| BBL036385 |
| 5-methyl-4-nitro-2-(4-nitrophenyl)-2,4-dihydro-3h-pyrazol-3-one |
| Q27274147 |
| 3-methyl-4-nitro-1-(4-nitrophenyl)-5-pyrazolone |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The aim of this work was to evaluate antidiabetic activity in Streptozotocin (STZ)-induced diabetic rats and the antioxidant effects of 3',4'-Di-O-acetyl-cis-khellactone (DOAcK), as well as its toxic potential." | ( Antidiabetic effect, antioxidant activity, and toxicity of 3',4'-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats. Burgueño-Tapia, E; Cornejo-Garrido, J; Domínguez-Mendoza, EA; Ordaz-Pichardo, C, 2016) | 0.43 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " This method was successfully applied for famotidine assay from pharmaceutical dosage forms." | ( [UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate]. Apostu, M; Bibire, N; Dorneanu, V, ) | 0.37 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 12.5893 | 0.1800 | 13.5574 | 39.8107 | AID1460 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 19.9526 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 10.0000 | 0.8913 | 10.4328 | 20.5750 | AID1379 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 39.8107 | 0.3548 | 28.0659 | 89.1251 | AID504847 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1636320 | Mutagenicity in Salmonella typhimurium TA98 assessed as mutagenic index at 0.19 uM/plate after 48 hrs in absence of S9 fraction by Ames test relative to control | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antidiabetic effect, antioxidant activity, and toxicity of 3',4'-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (25.31) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||