Compounds > phenylheptatriyne
Page last updated: 2024-12-07

phenylheptatriyne

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phenylheptatriyne: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID77981
CHEMBL ID444776
CHEBI ID671
MeSH IDM0072020

Synonyms (18)

Synonym
benzene, 1,3,5-heptatriynyl-
bl44u3v466 ,
unii-bl44u3v466
1,3,5-heptatriynyl-benzene
C08456
phenylheptatriyne
4300-27-0
1-phenylhepta-1,3,5-triyne
hepta-1,3,5-triynylbenzene
1-phenyl-1,3,5-heptatriyne
chebi:671 ,
CHEMBL444776
A827067
DTXSID00195622
Q27105327
benzene, 1,3,5-heptatriyn-1-yl-
phenyl-1,3,5-heptatriyne, 1-
1,3,5-heptatriyn-1-ylbenzene

Research Excerpts

Effects

ExcerptReferenceRelevance
"Phenylheptatriyne has shown significant activity against investigated strains, and the Minimal Inhibitory Concentrations for Candida spp."( In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts.
Avdeeva, LV; Klochko, VV; Nagorna, SS; Ostapchuk, AN; Prykhodko, VA; Rybalchenko, NP; Rybalchenko, TV; Volynets, NN, 2010)		1.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (80)

Assay IDTitleYearJournalArticle
AID380637Phototoxicity against Microsporum cookei at 5 ug/disk in presence of cool-white fluorescent light
AID380661Effect on human skin fibroblast cells assessed as viable cell count at 10 ug/ml in petroleum ether after 5.33 Joules/cm UV irradiation for 60 mins by trypan blue exclusion method
AID380316Phototoxicity against Streptococcus faecalis at 5 ug/disk in presence of long wave UV light
AID380636Phototoxicity against Microsporum cookei at 5 ug/disk in presence of long wave UV light
AID380901Photochemical activity against denatured calf thymus DNA at 10 ug after UV irradiation with 16.00 Joules/cm'2 for 180 mins by hyperchromicity test
AID380626Phototoxicity against Fusarium sp. at 5 ug/disk in dark
AID380638Phototoxicity against Microsporum cookei at 5 ug/disk in dark
AID380336Phototoxicity against Pseudomonas fluorescens at 5 ug/disk in presence of cool-white fluorescent light
AID380624Phototoxicity against Fusarium sp. at 5 ug/disk in presence of long wave UV light
AID380310Phototoxicity against Staphylococcus albus at 5 ug/disk in presence of long wave UV light
AID380324Phototoxicity against Escherichia coli at 5 ug/disk in dark
AID380632Phototoxicity against Microsporum canis at 5 ug/disk in dark
AID380650Phototoxicity against Trichophyton mentagrophytes at 5 ug/disk in dark
AID380649Phototoxicity against Trichophyton mentagrophytes at 5 ug/disk in presence of cool-white fluorescent light
AID380907Phototoxicity against Candida albicans at 2.5 ug/disk after UV irradiation for 30 mins
AID380662Effect on human skin fibroblast cells assessed as viable cell count at 10 ug/ml in petroleum ether after 8.00 Joules/cm UV irradiation for 90 mins by trypan blue exclusion method
AID380655Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether in dark after 15 mins
AID380591Phototoxicity against Pseudomonas fluorescens at 5 ug/disk in dark
AID380311Phototoxicity against Staphylococcus albus at 5 ug/disk in presence of cool-white fluorescent light
AID380599Phototoxicity against Saccharomyces cerevisiae at 2.5 ug/disk after UV irradiation for 30 mins
AID380902Photochemical activity against denatured calf thymus DNA at 10 ug in dark by hyperchromicity test
AID380595Phototoxicity against Candida albicans at 5 ug/disk in presence of long wave UV light
AID380648Phototoxicity against Trichophyton mentagrophytes at 5 ug/disk in presence of long wave UV light
AID380644Phototoxicity against Microsporum gypseum at 5 ug/disk in dark
AID380619Phototoxicity against Torula sp. at 5 ug/disk in presence of cool-white fluorescent light
AID380601Phototoxicity against Rhodotorula rubra Y96 at 5 ug/disk in presence of long wave UV light
AID380299Phototoxicity against Bacillus subtilis at 5 ug/disk in presence of cool-white fluorescent light
AID380654Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether after 16 Joules/cm'2 UV irradiation for 180 mins
AID380322Phototoxicity against Escherichia coli at 5 ug/disk in presence of long wave UV light
AID380659Effect on human skin fibroblast cells assessed as viable cell count at 10 ug/ml in petroleum ether after 1.78 Joules/cm UV irradiation for 20 mins by trypan blue exclusion method
AID380306Phototoxicity against Micrococcus roseus UBC 289 at 5 ug/disk in dark
AID380335Phototoxicity against Pseudomonas fluorescens at 5 ug/disk in presence of long wave UV light
AID380658Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether in dark after 180 mins
AID380905Photochemical activity against denatured calf thymus DNA at in dark after 120 mins by hyperchromicity test
AID380609Phototoxicity against Saccharomyces cerevisiae at 5 ug/disk in dark
AID380318Phototoxicity against Streptococcus fecalis at 5 ug/disk in dark
AID380330Phototoxicity against Proteus mirabilis UBC 5 at 5 ug/disk in dark
AID380607Phototoxicity against Saccharomyces cerevisiae at 5 ug/disk in presence of long wave UV light
AID380596Phototoxicity against Candida albicans at 5 ug/disk in presence of cool-white fluorescent light
AID380618Phototoxicity against Torula sp. at 5 ug/disk in presence of long wave UV light
AID380903Photochemical activity against denatured calf thymus DNA at 10 ug in dark after 30 mins by hyperchromicity test
AID380329Phototoxicity against Proteus mirabilis UBC 5 at 5 ug/disk in presence of cool-white fluorescent light
AID380323Phototoxicity against Escherichia coli at 5 ug/disk in presence of cool-white fluorescent light
AID380894Phototoxicity against Saccharomyces cerevisiae at 2.5 ug/disk after UV irradiation for 15 mins
AID380603Phototoxicity against Rhodotorula rubra Y96 at 5 ug/disk in dark
AID380608Phototoxicity against Saccharomyces cerevisiae at 5 ug/disk in presence of cool-white fluorescent light
AID380899Photochemical activity against denatured calf thymus DNA at 10 ug after UV irradiation with 5.33 Joules/cm'2 for 60 mins by hyperchromicity test
AID380305Phototoxicity against Micrococcus roseus UBC 289 at 5 ug/disk in presence of cool-white fluorescent light
AID380312Phototoxicity against Staphylococcus albus at 5 ug/disk in dark
AID380653Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether after 5.33 Joules/cm'2 UV irradiation for 60 mins
AID380900Photochemical activity against denatured calf thymus DNA at 10 ug after UV irradiation with 10.67 Joules/cm'2 for 120 mins by hyperchromicity test
AID380666Phototoxicity against Candida albicans at 2.5 ug/disk after UV irradiation for 15 mins
AID380642Phototoxicity against Microsporum gypseum at 5 ug/disk in presence of long wave UV light
AID380897Photochemical activity against denatured calf thymus DNA at 10 ug by hyperchromicity test
AID380328Phototoxicity against Proteus mirabilis UBC 5 at 5 ug/disk in presence of long wave UV light
AID380651Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether after 1.33 Joules/cm'2 UV irradiation for 15 mins
AID380906Photochemical activity against denatured calf thymus DNA at in dark after 180 mins by hyperchromicity test
AID380643Phototoxicity against Microsporum gypseum at 5 ug/disk in presence of cool-white fluorescent light
AID380614Phototoxicity against Sporobolomyces sp. Y138 at 5 ug/disk in presence of cool-white fluorescent light
AID380615Phototoxicity against Sporobolomyces sp. Y138 at 5 ug/disk in dark
AID380652Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether after 2.67 Joules/cm'2 UV irradiation for 30 mins
AID380657Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether in dark after 60 mins
AID380660Effect on human skin fibroblast cells assessed as viable cell count at 10 ug/ml in petroleum ether after 3.53 Joules/cm UV irradiation for 40 mins by trypan blue exclusion method
AID380296Phototoxicity against Saccharomyces cerevisiae at 2.5 ug/disk after UV irradiation for 180 mins
AID380298Phototoxicity against Bacillus subtilis at 5 ug/disk in presence of long wave UV light
AID380664Effect on human skin fibroblast cells assessed as viable cell count at 10 ug/ml in petroleum ether in dark after 60 mins by trypan blue exclusion method
AID380656Effect on Saccharomyces cerevisiae assessed as viable cell count at 10 ug/ml in petroleum ether in dark after 30 mins
AID380630Phototoxicity against Microsporum canis at 5 ug/disk in presence of long wave UV light
AID380602Phototoxicity against Candida albicans at 2.5 ug/disk after UV irradiation for 180 mins
AID380625Phototoxicity against Fusarium sp. at 5 ug/disk in presence of cool-white fluorescent light
AID380300Phototoxicity against Bacillus subtilis at 5 ug/disk in dark
AID380620Phototoxicity against Torula sp. at 5 ug/disk in dark
AID380304Phototoxicity against Micrococcus roseus UBC 289 at 5 ug/disk in presence of long wave UV light
AID380631Phototoxicity against Microsporum canis at 5 ug/disk in presence of cool-white fluorescent light
AID380904Photochemical activity against denatured calf thymus DNA at 10 ug in dark after 60 mins by hyperchromicity test
AID380597Phototoxicity against Candida albicans at 5 ug/disk in dark
AID380613Phototoxicity against Sporobolomyces sp. Y138 at 5 ug/disk in presence of long wave UV light
AID380317Phototoxicity against Streptococcus faecalis at 5 ug/disk in presence of cool-white fluorescent light
AID380898Photochemical activity against denatured calf thymus DNA 10 ug after UV irradiation with 2.67 Joules/cm'2 for 30 mins at by hyperchromicity test
AID380663Effect on human skin fibroblast cells assessed as viable cell count at 10 ug/ml in petroleum ether after 10.67 Joules/cm UV irradiation for 120 mins by trypan blue exclusion method
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (66.67)18.7374
1990's0 (0.00)18.2507
2000's2 (13.33)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.22 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.		1.9710aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
tolonium chloride
Tolonium Chloride: A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.. tolonium chloride : An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.		1.9710
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.8840mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
ricinine
[no description available]		2.1110nitrile;
pyridine alkaloid;
pyridone
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		1.9510dihydrogen
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		1.9510pseudohalide anionmitochondrial respiratory-chain inhibitor
acridine orange
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.		1.9710aminoacridines;
aromatic amine;
tertiary amino compound		fluorochrome;
histological dye
alpha-terthienyl
[no description available]		2.6630terthiophene
thiarubrine a
thiarubrine A: dithiin polyacetylene; bioactive constituent of Aspilia (Asteraceae); structure given in first source		1.9610organosulfur heterocyclic compound
thiophene a
thiophene A: RN not in Chemline 4/87; RN from Chem Abstracts Index Guide 1986; structure given in first source		1.9610
parthenin
parthenin: sesqiterpene lactone from Parthenium hysterophorus; structure; RN given refers to 3aS-(3aalpha,6beta,6abeta,9abeta,9balpha)-isomer		2.1110sesquiterpene lactone
sesquiterpenes
[no description available]		2.1110
harmine
Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.. harmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.		1.9710harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		1.9610chalcogen;
nonmetal atom		macronutrient
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.96101,2-diacyl-sn-glycero-3-phosphocholine
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		02.1110
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.1110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0610
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		01.9610
Extravascular Hemolysis
[description not available]		01.9710
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		06.9710