Compounds > pestalone
Page last updated: 2024-11-12

pestalone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pestalone: produced by a marine fungus, Pestalotia sp. in response to bacterial challenge; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10071878
CHEMBL ID489144
MeSH IDM0409181

Synonyms (3)

Synonym
CHEMBL489144
pestalone
2-(3,5-dichloro-2-hydroxy-6-methoxy-4-methylbenzoyl)-4,6-dihydroxy-3-(3-methylbut-2-enyl)benzaldehyde

Research Excerpts

Overview

Pestalone (1) is a prominent marine natural product. It was first isolated by M. Sebastian Hoffman.

ExcerptReferenceRelevance
"Pestalone (1) is a prominent marine natural product first isolated by M. "( On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
Augner, D; Benting, J; Gerbino, DC; Hillebrand, S; Krönke, M; Krut, O; Nising, CF; Sahl, HG; Schmalz, HG; Slavov, N, 2013)		2.09
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID762988Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microdilution method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762971Antifungal activity against Trametes versicolor after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID358286Cytotoxicity against human NCI60 cells2001Journal of natural products, Nov, Volume: 64, Issue:11
Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge.
AID762986Antimicrobial activity against Staphylococcus aureus SG511 after 24 hrs by broth microdilution method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762979Antifungal activity against Alternaria mali after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762983Antifungal activity against Phytophthora cryptogea after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762976Antifungal activity against Pyrenophora teres after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID358287Antibacterial activity against methicillin-resistant Staphylococcus aureus2001Journal of natural products, Nov, Volume: 64, Issue:11
Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge.
AID762973Antifungal activity against Aspergillus niger after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID1528558Antiproliferative activity against human PANC1 cells incubated for 72 hrs by MTT assay2019Journal of natural products, 12-27, Volume: 82, Issue:12
Benzophenone Compounds, from a Marine-Derived Strain of the Fungus
AID762974Antifungal activity against Fusarium culmorum after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762985Antimicrobial activity against methicillin-resistant Staphylococcus aureus LT-1334 after 24 hrs by microdilution method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762987Antimicrobial activity against Bacillus subtilis 168 after 24 hrs by broth microdilution method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762992Antifungal activity against Septoria tritici after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID358288Antibacterial activity against vancomycin-resistant Enterococcus faecium2001Journal of natural products, Nov, Volume: 64, Issue:11
Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge.
AID762991Antimicrobial activity against epidemic community acquired methicillin-resistant Staphylococcus aureus USA300 after 24 hrs by microdilution method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762972Antifungal activity against Pseudomonas fluorescens after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID377842Antibacterial activity against Staphylococcus aureus2005Journal of natural products, Apr, Volume: 68, Issue:4
Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
AID762978Antifungal activity against Botrytis cinerea after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762984Antifungal activity against Pyricularia oryzae after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762990Antimicrobial activity against hospital acquired vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by microdilution method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762977Antifungal activity against Leptosphaeria nodorum after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762980Antifungal activity against Pythium aphanidermatum after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762981Antifungal activity against Gibberella zeae after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID377843Antibacterial activity against Enterococcus faecium2005Journal of natural products, Apr, Volume: 68, Issue:4
Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
AID762975Antifungal activity against Ustilago avenae after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
AID762982Antifungal activity against Phytophthora infestans after 3 to 5 days by photometric method2013Journal of natural products, Aug-23, Volume: 76, Issue:8
On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.66 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.44 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		2.0710sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.2110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.		2.2110aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
phthalide
2-benzofuran-1(3H)-one : A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.. isobenzofuranone : A 2-benzofuran containing one or more oxo groups.		2.07102-benzofurans;
gamma-lactone
cyclohexanone
[no description available]		2.0510cyclohexanoneshuman xenobiotic metabolite
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0810glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		2.0510
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Resistance
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.		02.0810
Cancer of Pancreas
[description not available]		02.2110
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.2110