Compounds > pendolmycin
Page last updated: 2024-12-08

pendolmycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pendolmycin: indole alkaloid from Nocardiopsis; inhibitor of phosphatidylinositol turnover & binding of epidermal growth factor; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID154206
CHEMBL ID519751
CHEBI ID69600
MeSH IDM0165029

Synonyms (9)

Synonym
pendolmycin
CHEMBL519751
chebi:69600 ,
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 9-(1,1-dimethyl-2-propenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2s-(2r*,5r*))-
ccris 4043
119375-01-8
DTXSID10152428
Q27137942
(10s,13s)-13-(hydroxymethyl)-9-methyl-5-(2-methylbut-3-en-2-yl)-10-propan-2-yl-3,9,12-triazatricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one

Research Excerpts

Overview

Pendolmycin is a new indole alkaloid isolated from Nocardiopsis. It is an inhibitor of phosphatidylinositol turnover.

ExcerptReferenceRelevance
"Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidylinositol turnover. "( Modification of cellular membrane functions by pendolmycin.
Imoto, M; Sawa, T; Takeuchi, T; Umezawa, K; Yamashita, T, 1989)		1.98

Effects

ExcerptReferenceRelevance
"Pendolmycin has a C5 dimethyl allyl group attached to C-7 of (-)-indolactam-V, whereas teleocidin A has a C10 linalyl group attached to the molecule."( Pendolmycin, a new tumor promoter of the teleocidin A class on skin of CD-1 mice.
Fujiki, H; Furuya-Suguri, H; Muratake, H; Nakayasu, M; Natsume, M; Nishiwaki, S; Okabe, K; Okabe, S; Suganuma, M; Yoshizawa, S, 1991)		2.45
"Pendolmycin has a C5 dimethyl allyl group attached to C-7 of (-)-indolactam-V, whereas teleocidin A has a C10 linalyl group attached to the molecule."( Pendolmycin, a new tumor promoter of the teleocidin A class on skin of CD-1 mice.
Fujiki, H; Furuya-Suguri, H; Muratake, H; Nakayasu, M; Natsume, M; Nishiwaki, S; Okabe, K; Okabe, S; Suganuma, M; Yoshizawa, S, 1991)		2.45
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
indolesAny compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID636818Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID636817Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID636815Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID1870481Inhibition of GLI in SAG induced mouse Shh Light II cells assessed as residual Smo-dependent Gli luciferase activity in starvation medium at 100 nM incubated for 30 hrs by dual luciferase assay2022ACS medicinal chemistry letters, Jul-14, Volume: 13, Issue:7
Indolactam Dipeptides as Nanomolar Gli Inhibitors.
AID636822Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID636819Cytotoxicity against human A549 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID1870480Inhibition of GLI in SAG induced mouse Shh Light II cells assessed as residual Smo-dependent Gli luciferase activity in starvation medium incubated for 30 hrs by dual luciferase assay2022ACS medicinal chemistry letters, Jul-14, Volume: 13, Issue:7
Indolactam Dipeptides as Nanomolar Gli Inhibitors.
AID636816Cytotoxicity against human SW1990 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID636821Cytotoxicity against human DU145 cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID1870484Inhibition of GLI in SAG induced mouse Sufu-KO-LIGHT cells assessed as residual Smo-independent Gli luciferase activity in starvation medium incubated for 30 hrs by dual luciferase assay2022ACS medicinal chemistry letters, Jul-14, Volume: 13, Issue:7
Indolactam Dipeptides as Nanomolar Gli Inhibitors.
AID636820Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2011Journal of natural products, Oct-28, Volume: 74, Issue:10
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
AID1870485Inhibition of GLI in SAG induced mouse Sufu-KO-LIGHT cells assessed as residual Smo-independent Gli luciferase activity in starvation medium at 100 nM incubated for 30 hrs by dual luciferase assay2022ACS medicinal chemistry letters, Jul-14, Volume: 13, Issue:7
Indolactam Dipeptides as Nanomolar Gli Inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0610aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9710acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
teleocidin b-4
teleocidins: structure; RN given refers to teleocidin		2.4220
lyngbyatoxin a
lyngbyatoxin A: indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as swimmers' itch in Hawaii		2.7630indoles
indolactam v
indolactam V: only the (-)-isomer of indolactam V showed carcinogenic activity; structure given in first source		2.4420indoles
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		1.9710icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
1-acetyl-beta-carboline
1-acetyl-beta-carboline: structure in first source		2.0610harmala alkaloidmetabolite
gdc 0449
HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity		2.4110benzamides;
monochlorobenzenes;
pyridines;
sulfone		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Skin
[description not available]		01.9710
Skin Neoplasms
Tumors or cancer of the SKIN.		01.9710