Compounds > pd 128483
Page last updated: 2024-11-07

pd 128483

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

PD 128483: structure given in first source; a potential antipsychotic drug candidate found to be a potent frameshift mutagen [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID130792
CHEMBL ID350920
SCHEMBL ID10665477
MeSH IDM0199808

Synonyms (28)

Synonym
b054zgi96w ,
115688-97-6
unii-b054zgi96w
4,5,5a,6,7,8-hexahydro-6-methylthiazolo(4,5-f)quinoline-2-amine
pd 128483
4,5,5a,6,7,8-hexahydro-6-methylthiazolo(4,5-f)quinolin-2-amine
pd-128483
ccris 4394
thiazolo(4,5-f)quinolin-2-amine, 4,5,5a,6,7,8-hexahydro-6-methyl-, (+-)-
CHEMBL350920
6-methyl-5,5a,7,8-tetrahydro-4h-[1,3]thiazolo[4,5-f]quinolin-2-amine
ccris 6698
6-methyl-4,5,5a,6,7,8-hexahydrothiazolo(4,5-f)quinolin-2-amine
153260-23-2
XFJSSDHKIXXJLM-UHFFFAOYSA-N ,
(+) 4,5,5a,6,7,8-hexahydro-6-methylthiazolo[4,5-f]quinolin-2-amine
SCHEMBL10665477
pd-128483, (+/-)-
thiazolo(4,5-f)quinolin-2-amine, 4,5,5a,6,7,8-hexahydro-6-methyl-
thiazolo(4,5-f)quinolin-2-amine, 4,5,5a,6,7,8-hexahydro-6-methyl-, (+/-)-
thiazolo[4,5-f]quinolin-2-amine, 4,5,5a,6,7,8-hexahydro-6-methyl-, (+/-)-
6-methyl-4,5,5a,6,7,8-hexahydro[1,3]thiazolo[4,5-f]quinolin-2(1h)-imine
DTXSID20921788
Q27896723
(+/-)-pd-128483
6-methyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine
4,5,5a,6,7,8-hexahydro-6-methylthiazolo[4,5-f]quinoline-2-amine
thiazolo[4,5-f]quinolin-2-amine, 4,5,5a,6,7,8-hexahydro-6-methyl-, ()-

Research Excerpts

Actions

ExcerptReferenceRelevance
"(+)-PD 128483 did not inhibit avoidance responding."( Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers.
Caprathe, BW; Christoffersen, CL; Corbin, AE; Jaen, JC; Meltzer, LT; Ninteman, FW; Pugsley, TA; Serpa, KA; Shih, YH; Whetzel, SZ, 1993)		1.01

Compound-Compound Interactions

ExcerptReferenceRelevance
" The present study was designed to evaluate PD 128483 ((+)-4,5,5a,6,7,8-hexahydro-6-methyl-thiazolo[4,5-f]quinoline-2-amine) alone and in combination with cocaine in three behavioral paradigms."( Behavioral effects of the dopamine autoreceptor agonist PD 128483 alone and in combination with cocaine.
Vanover, KE; Woolverton, WL, 1994)		0.8

Dosage Studied

ExcerptRelevanceReference
") decreased milk intake in rats (n = 9) and, when given in combination with cocaine, shifted the cocaine dose-response function (4."( Behavioral effects of the dopamine autoreceptor agonist PD 128483 alone and in combination with cocaine.
Vanover, KE; Woolverton, WL, 1994)		0.53
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amphetamine
Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.. 1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.. amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.		1.9810primary amine
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		1.9810aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
talipexole
talipexole: dopamine receptor agonist; structure given in first source		1.9810azepine
apomorphine
Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.		2.3920aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		1.9810butan-4-olidemetabolite;
neurotoxin
thiazoles
[no description available]		3.08501,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pramipexole
Pramipexole: A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.. pramipexole : A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.		2.3920benzothiazoles;
diamine		antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
radical scavenger
cocaine
Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.		6.9810benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
preclamol
preclamol: centrally acting dopamine receptor agonist with selectivity for autoreceptors		1.9810
piperidines
Piperidines: A family of hexahydropyridines.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.3920