Compounds > oxynitidine
Page last updated: 2024-12-07

oxynitidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

oxynitidine: structure in frist source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID97597
CHEMBL ID488611
MeSH IDM0498961

Synonyms (20)

Synonym
nsc-135066
oxynitidine
548-31-2
nsc135066
2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-13-one
6-oxynitidine
CHEMBL488611
2,3-dimethoxy-12-methyl-12h-[1,3]dioxolo-[4',5':4,5]benzo[1,2-c]phenanthridin-13-one
(1,3)benzodioxolo(5,6-c)phenanthridin-13(12h)-one, 2,3-dimethoxy-12-methyl-
1wh82ujd2g ,
unii-1wh82ujd2g
nsc 135066
c21h17no5
DTXSID40203275
2,3-dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridin-13(12h)-one
rhoifoline b
nsc782370
nsc-782370
HY-W676876
CS-0760766
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1363351Growth inhibition of human DU145 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1363345Binding affinity to F10T dsDNA (unknown origin) assessed as change in melting temperature at 2 uM after 0.5 hrs by FRET assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1363342Inhibition of recombinant human TDP1 at 100 uM using 5'FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence-based assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1363352Growth inhibition of human A549 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1363341Inhibition of recombinant TOP1 (unknown origin)-mediated 3'-[32P]-labeled 117-bp DNA oligonucleotide cleavage assessed as induction of protein-DNA covalent cleavage complex formation after 20 mins by PAGE analysis2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1566678Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
AID1363349Growth inhibition of human HCT116 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1566680Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
AID338342In vivo antitumor activity against mouse P388 cells at 30 to 50 mg/kg, ip relative to control
AID1566679Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
AID1566677Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
AID1566675Inhibition of recombinant TOP1 (unknown origin) using 3'-[32P]-labeled 117 bp DNA oligonucleotide assessed as decrease in TOP1-mediated DNA cleavage incubated for 20 mins by PAGE analysis relative to 1 uM CPT2019European journal of medicinal chemistry, Sep-15, Volume: 178Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
AID1363350Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1363353Growth inhibition of human HuH7 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID1363340Inhibition of recombinant TOP1 (unknown origin)-mediated 3'-[32P]-labeled 117-bp DNA oligonucleotide cleavage assessed as induction of protein-DNA covalent cleavage complex formation at 1 uM after 20 mins by PAGE analysis relative to camptothecin2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzonitrile
benzonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a phenyl group.		2.0310benzenes;
nitrile
ethidium bromide
[no description available]		2.1710organic bromide saltgeroprotector;
intercalator;
trypanocidal drug
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.5920delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
nsc 706744
[no description available]		2.5920
n'-(10h-indolo(3,2-b)quinolin-11-yl)-n,n-dimethylpropane-1,3-diamine
[no description available]		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.2110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.2110