Compounds > oxazepam acetate
Page last updated: 2024-12-07

oxazepam acetate

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Description

Oxazepam acetate is a prodrug of oxazepam, a benzodiazepine used to treat anxiety and insomnia. It is synthesized by reacting oxazepam with acetic anhydride. Oxazepam acetate is rapidly absorbed after oral administration and is hydrolyzed to oxazepam in the body. Oxazepam is a potent anxiolytic and sedative with a rapid onset of action. It is also used to treat alcohol withdrawal symptoms. Oxazepam acetate is studied because it offers a convenient and effective way to administer oxazepam. It is particularly useful for patients who have difficulty swallowing tablets or capsules.'

oxazepam acetate: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID102697
CHEMBL ID146245
SCHEMBL ID10513690
MeSH IDM0091091

Synonyms (29)

Synonym
7-chloro-2-oxo-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-3-yl acetate
oxazepam acetate
1824-74-4
CHEMBL146245
3-acetoxy-7-chloro-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepin-2-one
(7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl) acetate
acetic acid (7-chloro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl) ester
7-chloro-1,3-dihydro-5-phenyl-2-oxo-2h-1,4-benzodiazepin-3-yl acetate
(7-chloranyl-2-oxidanylidene-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl) ethanoate
A812994
A812699
unii-611v4315ua
611v4315ua ,
einecs 217-359-6
(+/-)-oxazepam 3-acetate
(3rs)-7-chloro-2-oxo-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-3-yl acetate
(+/-)-oxazepam acetate
2h-1,4-benzodiazepin-2-one, 3-(acetyloxy)-7-chloro-1,3-dihydro-5-phenyl-
oxazepam impurity b [ep impurity]
3-acetoxy-7-chloro-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepine-one
FYRWUTOZBRWYCS-UHFFFAOYSA-N
SCHEMBL10513690
W-109125
AKOS030241640
3-acetoxy-7-cholro-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepin-2-one
DB14672
DTXSID40939582
7-chloro-2-hydroxy-5-phenyl-3h-1,4-benzodiazepin-3-yl acetate
Q27263273
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID1131184Antimetrazol activity in iv dosed mouse assessed as inhibition of metrazol-induced tonic-extensor seizures administered 30 mins prior to metrazol challenge1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID1131199Drug metabolism in mouse liver microsomes assessed as rate of esterase-mediated compound hydrolysis measured per mg of protein by pH stat based titrimetric analysis1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID127661Compound was evaluated for the antimetrazole effect by administering through intravenous route at the pretreatment period of 120 min1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Oxazepam esters. 3. Intrinsic activity, selectivity, and prodrug effect.
AID1131187Muscle relaxant activity in iv dosed mouse after 60 mins by rotarod test1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID407138Antiviral activity against hepatitis B virus infected Hep G2.2.15 cells assessed as inhibition of HBeAg secretion2008Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.
AID1131186Muscle relaxant activity in iv dosed mouse after 30 mins by rotarod test1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID1131228Fraction unbound in 22% albino mouse serum at 10 uM by equilibrium dialysis method in presence of diisopropyl fluorophosphate1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 2. Correlation of hydrophobicity with serum binding, brain penetration, and excretion.
AID1131208Ratio of ED50 for muscle relaxant activity in mouse to ED50 for antimetrazol activity in mouse measured after 60 mins1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID127659Compound was evaluated for the antimetrazole effect by administering through intravenous route at the pretreatment period 240 min1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Oxazepam esters. 3. Intrinsic activity, selectivity, and prodrug effect.
AID407142Selectivity index, ratio of CC50 for human Hep G2.2.15 cells to IC50 for HBV e antigen secretion2008Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.
AID407141Selectivity index, ratio of CC50 for human Hep G2.2.15 cells to IC50 for HBV surface antigen secretion2008Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.
AID1131188Ratio of ED50 for muscle relaxant activity in mouse to ED50 for antimetrazol activity in mouse measured after 30 mins1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID407139Antiviral activity against hepatitis B virus infected Hep G2.2.15 cells assessed as inhibition of HBsAg secretion2008Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.
AID127697Compound was evaluated for the muscle relaxant effect by administering through intravenous route at the pretreatment period of 240 min1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Oxazepam esters. 3. Intrinsic activity, selectivity, and prodrug effect.
AID407140Cytotoxicity against human Hep G2.2.15 cells2008Bioorganic & medicinal chemistry letters, Jul-01, Volume: 18, Issue:13
Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.
AID127695Compound was evaluated for the muscle relaxant effect by administering through intravenous route at the pretreatment period of 120 min1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Oxazepam esters. 3. Intrinsic activity, selectivity, and prodrug effect.
AID1131185Antimetrazol activity in iv dosed mouse assessed as inhibition of metrazol-induced tonic-extensor seizures administered 60 mins prior to metrazol challenge1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam.
AID1131229Prodrug conversion in 22% albino mouse serum assessed as oxazepam content at 10 uM by equilibrium dialysis method in presence of diisopropyl fluorophosphate1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 2. Correlation of hydrophobicity with serum binding, brain penetration, and excretion.
AID1131230Binding affinity to human serum albumin at 10 uM after 12 to 20 hrs by scintillation spectrometry1979Journal of medicinal chemistry, Dec, Volume: 22, Issue:12
Oxazepam esters. 2. Correlation of hydrophobicity with serum binding, brain penetration, and excretion.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (63.64)18.7374
1990's2 (18.18)18.2507
2000's2 (18.18)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.72 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nordazepam
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.. nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.		2.04101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
GABA modulator;
human metabolite;
sedative
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		1.96101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		2.0310monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
lorazepam
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.		2.8940benzodiazepine
cm 7116
norflutoprazepam: structure		2.0410benzodiazepine
oxazepam
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.. oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.		3.671001,4-benzodiazepinone;
organochlorine compound		anxiolytic drug;
environmental contaminant;
xenobiotic
lorazepam acetate
lorazepam acetate: RN given refers to unlabeled cpd without isomeric designation		2.8940
chlordesmethyldiazepam
[no description available]		2.0410benzodiazepine
lamivudine
[no description available]		2.0410monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		1.9510monohydroxybenzoateplant metabolite
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		1.9610benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatitis B Virus Infection
[description not available]		02.0410
Hepatitis B
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		02.0410