Compounds > olivomycin a
Page last updated: 2024-12-07

olivomycin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

olivomycin A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122806
CHEMBL ID576383
CHEBI ID52511
SCHEMBL ID606942
MeSH IDM0083970

Synonyms (13)

Synonym
olivomycin a
olivomycin d, 3(b)-o-(2,6-dideoxy-3-c-methyl-4-o-(2-methyl-1-oxopropyl)-alpha-l-arabino-hexopyranosyl)-
olivomycin i
6988-58-5
CHEBI:52511 ,
CHEMBL576383
unii-06720j8x69
06720j8x69 ,
olivomycin d, 3d-o-(2,6-dideoxy-3-c-methyl-4-o-(2-methyl-1-oxopropyl)-.alpha.-l-arabino-hexopyranosyl)-
olivomycin a [mi]
SCHEMBL606942
Q27123480
DTXSID101024454

Research Excerpts

Overview

Olivomycin A is a highly active antitumor drug. It belongs to the family of aureolic acid antibiotics.

ExcerptReferenceRelevance
"Olivomycin A is a highly active antitumor drug that belongs to the family of aureolic acid antibiotics. "( The Effect of Antitumor Antibiotic Olivomycin A and Its New Semi-synthetic Derivative Olivamide on the Activity of Murine DNA Methyltransferase Dnmt3a.
Gromova, ES; Sergeev, AV; Tevyashova, AN; Vorobyov, AP, 2019)		2.23
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
olivomycinA class of several closely related glycosidic antibiotics obtained from Actinomyces (or Streptomyces) olivoreticuli.
secondary alpha-hydroxy ketoneAn alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary alpha-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID436712Antiproliferative against human HCT116 cells after 72 hrs2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436711Antiproliferative against human K562 cells after 72 hrs2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436717Antiviral activity against HIV1 3B infected in human CEM cells assessed as drug level required for protection against virus-induced cytopathogenicity after 4 days2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436709Antiproliferative against human Molt4/C8 cells after 72 hrs2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436713Inhibition of DNA topoisomerase 1 assessed as inhibition of unwinding of supercoiled pBR322 DNA at 10 to 20 uM by agarose gel electrophoresis2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436714Inhibition of DNA topoisomerase 1 assessed as partial inhibition of unwinding of supercoiled pBR322 DNA at 5 uM by agarose gel electrophoresis2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436708Antiproliferative against mouse L1210 cells after 48 hrs2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436710Antiproliferative against human CEM cells after 72 hrs2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
AID436718Antiviral activity against HIV2 ROD infected in human CEM cells assessed as drug level required for protection against virus-induced cytopathogenicity after 4 days2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.27 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.75 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycosides
[no description available]		2.0510
olivomycins
Olivomycins: A mixture of several closely related glycosidic antibiotics obtained from Actinomyces (or Streptomyces) olivoreticuli. They are used as fluorescent dyes that bind to DNA and prevent both RNA and protein synthesis and are also used as antineoplastic agents.		3.5780
apoptolidin
apoptolidin: an apoptosis inducer in transformed cells from Nocardiopsis sp.; structure in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Germinoblastoma
[description not available]		02.0610
Malignant Melanoma
[description not available]		02.0610
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		02.0610
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.0610
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9510