Compounds > octacosanoic acid
Page last updated: 2024-12-05

octacosanoic acid

Description

Octacosanoic acid, also known as montanic acid, is a saturated fatty acid with 28 carbon atoms. It is found in many natural sources, including beeswax, carnauba wax, and wool wax. It is also present in some plant oils. Octacosanoic acid has been studied for its potential applications in various fields. For example, it has been investigated as a potential bio-based lubricant, due to its high melting point and good thermal stability. The compound has also been studied for its potential use in the development of biodegradable polymers. Octacosanoic acid has a low toxicity and is generally considered safe for human consumption. However, further research is needed to fully understand its potential benefits and risks. '

octacosanoic acid: RN given refers to parent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

octacosanoic acid : A straight-chain saturated fatty acid that is octacosane in which one of the terminal methyl groups has been oxidised to the corresponding carboxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID10470
CHEMBL ID2261064
CHEBI ID31001
SCHEMBL ID49866
MeSH IDM0188019

Synonyms (40)

Synonym
octaeicosanoic acid
octacosoic acid
ch3-[ch2]26-cooh
1-octacosanoic acid
montanic acid
n-octacosanoic acid
octacosansaeure
octacosancarbonsaeure
CHEBI:31001 ,
n-octaeicosanoic acid
nsc-407311
506-48-9
nsc407311
octacosanoic acid
c28:0
LMFA01010028
octacosanoic acid, synthetic, >=98%
03D7DC3A-50B1-4BBA-9AF7-C86F38E231A2
M1342
4bkl1a0kjy ,
nsc 407311
einecs 208-041-8
unii-4bkl1a0kjy
AKOS015892943
CHEMBL2261064
montan acid ester
SCHEMBL49866
octacosanoic acid,synthetic
mfcd00002812
DTXSID2075051
octacosanoic acid, puriss., synthetic, >=98.5% (gc)
fa 28:0
octacosanoicacid
A855122
FT-0706014
octacosoate
Q911196
C21933
HY-N8425
CS-0144141

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Meanwhile, no adverse effects on reproductive performance, or on embryonic or fetal development, including visceral and skeletal examination, were seen in any of the groups administered D-003."( Lack of developmental toxicity of D-003: a mixture of long-chain fatty acids in rats.
Acosta, CP; Gámez, R; García, H; Goicochea, E; González, JE; Rodríguez, MD, 2003)		0.32

Dosage Studied

ExcerptRelevanceReference
"The present study demonstrates that octacosanoic acid is formed after incubation of fibroblast cultures with (3)H-octacosanol and after oral dosing with policosanol to rats."( In vitro and in vivo study of octacosanol metabolism.
Fernández, I; González, L; González, RM; Marrero, D; Más, R; Menéndez, R, )		0.41
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
straight-chain saturated fatty acidAny saturated fatty acid lacking a side-chain.
ultra-long-chain fatty acidAny very long-chain fatty acid which has a chain length greater than C27.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Elongation of (very) long chain fatty acids345

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1063391Induction of dendrite extension in rat cortical neurons assessed as inhibition of amyloid beta (25 to 35)-induced neuronal degeneration at 1 uM after 4 days by fluorescence microscopic analysis2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's9 (60.00)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.18 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.37 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0310alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
palmitic acid
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.		2.0510long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
lauric acid
dodecanoic acid : A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.		2.0210medium-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
antibacterial agent;
plant metabolite
behenic acid
behenic acid: RN given refers to parent cpd; structure. docosanoic acid : A straight-chain, C22, long-chain saturated fatty acid.		2.7730long-chain fatty acid;
straight-chain saturated fatty acid		plant metabolite
kainic acid
Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.		2.0210dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
oleanolic acid
[no description available]		1.9710hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
neutral red
Neutral Red: A vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.. neutral red : A hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0.		2.0110hydrochlorideacid-base indicator;
dye;
two-colour indicator
lignoceric acid
lignoceric acid: RN given refers to parent cpd; structure. tetracosanoic acid : A C24 straight-chain saturated fatty acid.		2.4420straight-chain saturated fatty acid;
very long-chain fatty acid		Daphnia tenebrosa metabolite;
human metabolite;
plant metabolite;
volatile oil component
tritriacontane
tritriacontane : A long-chain alkane consisting of an unbranched chain of 33 carbon atoms.		2.0310long-chain alkane
tetrabutylammonium
tetrabutylammonium: lipophilic probe; RN given refers to parent cpd		2.0210quaternary ammonium ion
perfluidone
perfluidone: structure		2.0710sulfonamide
mefluidide
Mefluidide: structure in first source		2.0710sulfonamide
metazachlor
metazachlor: alpha-chloroacetamide herbicide. metazachlor : An organochlorine compound that is 2-chloroacetamide substituted by a 2,6-dimethylphenyl and a (1H-pyrazol-1-ylmethyl) group at the nitrogen atom.		2.0710aromatic amide;
organochlorine compound;
pyrazoles		environmental contaminant;
herbicide;
xenobiotic
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.0310D-glucopyranoseepitope;
mouse metabolite
delphinidin
Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.. delphinidin chloride : An anthocyanidin chloride that has delphinidin as the cationic counterpart.		2.0310anthocyanidin chloride
taraxerone
taraxerone: structure		1.9710scalarane sesterterpenoidmetabolite
scopolin
[no description available]		2.0310beta-D-glucoside;
coumarins;
monosaccharide derivative		plant metabolite
gamma-sitosterol
clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.		2.4203beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
sesquiterpenes
[no description available]		2.0310
cytellin
cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982		2.420
stigmasterol
stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.		2.05103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
cetoleic acid
cetoleic acid: RN given refers to cpd with specified locant & without isomeric designation. cetoleic acid : A docosenoic acid having a cis-double bond at position 11.		2.110docosenoic acidDaphnia tenebrosa metabolite
diosgenone
diosgenone: RN given for (25R)-isomer; isolated from Solanum nudum; structure in first source		2.0110
phytosterols
Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.		2.0310
lyoniside
lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer		2.420
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0310benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia
[description not available]		02.110
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.110
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0110
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		02.0110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0110
Weight Gain
Increase in BODY WEIGHT over existing weight.		02.0110
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