o-4-methylthymine profile

O(4)-methylthymine : A methylthymine in which the methyl group is located at the O4-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	65353
CHEBI ID	134100
SCHEMBL ID	230411
MeSH ID	M0075802

Synonym
o-4-methylthymine
o(4)-methylthymine
4-methoxy-5-methylpyrimidin-2(1h)-one
4-methoxy-5-methylpyrimidin-2-one
25902-89-0
CHEBI:134100
6-methoxy-5-methyl-1h-pyrimidin-2-one
AKOS006352885
2(1h)-pyrimidinone, 4-methoxy-5-methyl-
2(1h)-pyrimidinone,6-methoxy-5-methyl-
SCHEMBL230411
NWUTZAVMDAGNIG-UHFFFAOYSA-N
4-methoxy-5-methyl-2(1h)-pyrimidinone
DTXSID30180566
2(1h)-pyrimidinone, 4-methoxy-5-methyl- (8ci,9ci)
6-methoxy-5-methylpyrimidin-2(1h)-one

Excerpt	Reference	Relevance
" Expression of the ogt ATase provided greater protection against the toxic effects of the alkylating agents then the ada ATase particularly with N-ethyl-N-nitrosourea (ENU) and N-butyl-N-nitrosourea (BNU) to which the ada ATase expressing cells were as sensitive as parent vector transfected cells."	( Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas. Harris, LC; Margison, GP, 1993)	0.29

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
methylthymine	A pyrimidone that is thymine bearing a single methyl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (27.78)	18.7374
1990's	23 (63.89)	18.2507
2000's	2 (5.56)	29.6817
2010's	1 (2.78)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (5.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (94.87%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	1.98	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cytosine [no description available]	1.96	1	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
thymine [no description available]	6	36	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
o(6)-benzylguanine O(6)-benzylguanine: a suicide inhibitor of O(6)-methylguanine-DNA methyltransferase activity	2.69	3
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.97	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
2-acetylaminofluorene 2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.	1.97	1	2-acetamidofluorenes	antimitotic; carcinogenic agent; epitope; mutagen
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	1.97	1	nitrosamine	geroprotector; mutagen
2-aminopurine 2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.	1.98	1	2-aminopurines; nucleobase analogue	antimetabolite
2,6-diaminopurine 9H-purine-2,6-diamine : A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups.	1.98	1	2,6-diaminopurines; primary amino compound	antineoplastic agent
thymidine 5'-triphosphate thymidine 5'-triphosphate: RN given refers to parent cpd. dTTP : A thymidine phosphate having a triphosphate group at the 5'-position.	1.96	1	pyrimidine 2'-deoxyribonucleoside 5'-triphosphate; thymidine phosphate	Escherichia coli metabolite; mouse metabolite
o-(6)-methylguanine O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent.	5.56	23	methylguanine	mutagen
6-ethylguanine 6-ethylguanine: found in rat brain DNA	2.89	4
6'-o-methylguanosine [no description available]	1.98	1
4-(methylnitrosoamino)-4-(3-pyridyl)-1-butanol 4-(methylnitrosoamino)-4-(3-pyridyl)-1-butanol: tobacco-specific N-nitrosamine; structure given in first source	1.97	1
4-ethylthymine [no description available]	3.08	5
o(4)-methylthymidine triphosphate [no description available]	1.96	1
4-amino-2-methoxypyrimidine 4-amino-2-methoxypyrimidine: recognized by E. coli DNA repair enzymes; shown to exhibit strong miscoding properties. 2-O-methylcytosine : Pyrimidine substituted with a methoxy group at position C-2 and an amine group at C-4.	1.96	1	aminopyrimidine; aromatic ether; methylcytosine	metabolite
oligonucleotides [no description available]	7.4	2
deoxyguanosine triphosphate [no description available]	1.98	1	deoxyguanosine phosphate; guanyl deoxyribonucleotide; purine 2'-deoxyribonucleoside 5'-triphosphate	Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
guanine [no description available]	5.64	25	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	1.98	1	guanosines; purines D-ribonucleoside	fundamental metabolite
7-methylguanine 7-methylguanine: RN given refers to unlabeled cpd; structure. 7-methylguanine : A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.. 2-imino-7-methyl-1,2,3,7-tetrahydro-6H-purin-6-one : A 7-methylguanine that is 1,2,3,7-tetrahydro-6H-purin-6-one substituted by an imino group at position 2 and a methyl group at position 7.. 2-amino-7-methyl-7H-purin-6-ol : A 7-methylguanine that is 7H-purine substituted by an amino group at position 2, a methyl group at position 7 and a hydroxy group at position 6.. 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one : A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7.	2.17	1	7-methylguanine
methylnitronitrosoguanidine Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position	2.69	3	nitroso compound	alkylating agent
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	2.38	2

Condition	Relationship Strength	Studies
Glial Cell Tumors [description not available]	1.98	1
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	1.98	1
Kaposi Disease [description not available]	1.98	1
Xeroderma Pigmentosum A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.	1.98	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.38	2
Cancer of Colon [description not available]	2.38	2
Colonic Neoplasms Tumors or cancer of the COLON.	2.38	2
Cancer of Lung [description not available]	1.97	1
Lung Neoplasms Tumors or cancer of the LUNG.	1.97	1
Benign Neoplasms [description not available]	2.89	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.89	1
Cancer of Liver [description not available]	1.96	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.96	1

o-4-methylthymine

Description

Cross-References

Synonyms (16)

Research Excerpts

Toxicity

Roles (1)

Drug Classes (2)

Research

Studies (36)

Market Indicators

Research Demand Index: 10.89

Study Types