Compounds > o-(biotinylcarbazoylmethyl)hydroxylamine
Page last updated: 2024-11-06

o-(biotinylcarbazoylmethyl)hydroxylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

O-(biotinylcarbazoylmethyl)hydroxylamine: formed by reacting biotin hydrazide with O-(carboxymethyl)hydroxylamine in the presence of carbodiimide; used to tag AP sites in damaged DNA with biotin; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID83922
SCHEMBL ID829621
MeSH IDM0200380

Synonyms (13)

Synonym
o-(biotinylcarbazoylmethyl)hydroxylamine
5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n'-(2-aminooxyacetyl)pentanehydrazide
biotin-cmha
139585-03-8
1h-thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2-((aminooxy)acetyl)hydrazide, (3as,4s,6ar)-
1h-thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2-((aminooxy)acetyl)hydrazide, (3as-(3aalpha,4beta,6aalpha))-
aldehyde reactive probe
SCHEMBL829621
n-(aminooxyacetyl)-n'-(d-biotinoyl) hydrazine
DTXSID60930511
n-[2-(aminooxy)-1-hydroxyethylidene]-5-(2-hydroxy-3a,4,6,6a-tetrahydro-1h-thieno[3,4-d]imidazol-6-yl)pentanehydrazonic acid
n/'-aminooxymethylcarbonylhydrazino-d-biotin
PD070258
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's3 (27.27)29.6817
2010's5 (45.45)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.30 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.79 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.30)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methoxyamine
methoxyamine: analytical reagent for aldehydes and ketones; strong irritant, can probably produce methemoglobinemia; RN given refers to parent cpd; structure		2.1110organooxygen compound
methyl methanesulfonate
[no description available]		2.4220methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
hydrazine
diamine : Any polyamine that contains two amino groups.		2.0810azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
biotin hydrazide
biotin hydrazide: structure given in first source; RN given refers to (3aS-(3aalpha,4beta,6aalpha))-isomer		2.4220
deoxyglucose
Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.		1.9810
peroxynitrous acid
Peroxynitrous Acid: A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).		2.0610nitrogen oxoacid
3-(2'-deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3h)-one
3-(2'-deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one: a malondialdehyde-deoxyguanosine adduct; structure given in first source		2.0210
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		3.84110biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
deoxyguanosine
[no description available]		2.0210purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose.		2.0610guanosines;
purines D-ribonucleoside		fundamental metabolite
8-hydroxyguanosine
8-hydroxyguanosine: immunostimulant for B lymphocytes; structure given in first source		2.0610purine nucleoside
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1110
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.0610