Compounds > nsc319726
Page last updated: 2024-12-11

nsc319726

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5351307
CHEMBL ID1976486
SCHEMBL ID17975335
MeSH IDM000608544

Synonyms (21)

Synonym
LS-13960
azetidinecarbothioic acid, [1-(2-pyridinyl)ethylidene] hydrazide
NSC319726 ,
n-[(e)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide
BRD-K99170882-001-01-9
CHEMBL1976486
CCG-35689
S7149
(e)-n'-(1-(pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide
CS-3542
n'-(1-(pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide
HY-18634
AC-32867
AKOS024458479
SCHEMBL17975335
EX-A2113
cid 5351307
azetidine-1-carbothioic acid(1-pyridin-2-yl-ethylidene)hydrazide
A899911
AS-56104
WCA55525

Research Excerpts

Overview

NSC319726 is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H)

ExcerptReferenceRelevance
"NSC319726 (ZMC1) is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H). "( Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism.
Augeri, D; Blanden, AR; Carpizo, DR; Jayakumar, L; Kimball, SD; Loh, SN; Lubin, D; Narayanan, S; Yu, X, 2014)		1.85
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1749769Binding affinity to Zn(II)+ incubated for 60 mins using FluoZin-3 by fuorescence assay2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749774Induction of Zinc-dependent p53 R175H mutant refolding by assessing wild type conformation2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749768Binding affinity to Zn(II)+ incubated for 60 mins using RhodZin-3 by fuorescence assay2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749770Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749790Stability in simulated gastric fluid assessed as parent compound remaining measured after 7 hrs at room temperature2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749785Anticancer activity against human TOV112D cells harbouring p53 R175H mutant xenografted NCr nu/nu mouse assessed as tumor growth inhibition at 5.73 mg/kg, ip relative to control2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749772Induction of ROS production in human H1299 cells at 0.75 uM incubated for 24 hrs by CellRox green based fluorescence flow cytometry relative to ZMC12021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749771Ratio of EC50 for test compound to EC50 for ZMC1 for growth inhibition of human TOV-112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749783Toxicity in mouse assessed as maximum tolerated dose2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749773Apparent permeability in human Caco-2 cells at 5 uM measured up to 90 mins by LC-MS/MS analysis2021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
AID1749787Binding affinity to Cu(II)+ using CuSO42021Journal of medicinal chemistry, 02-25, Volume: 64, Issue:4
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's3 (37.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.87 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index28.17 (26.88)
Search Engine Supply Index2.56 (0.95)

This Compound (32.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitrilotriacetic acid
Nitrilotriacetic Acid: A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)		2.3110NTA;
tricarboxylic acid		carcinogenic agent;
nephrotoxic agent
lapatinib
[no description available]		2.2510furans;
organochlorine compound;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		2.2510
hki 272
[no description available]		2.2510nitrile;
quinolines		antineoplastic agent;
tyrosine kinase inhibitor
sepantronium
sepantronium: a survivin suppressant with antineoplastic activity. sepantronium : An organic cation that is 1-(2-methoxyethyl)-2-methyl-1H-naphtho[2,3-d]imidazole-4,9-dione in which the nitrogen at position 3 of the napthoimidazole moiety has been alkylated by a pyrazin-2-ylmethyl group.		2.2510organic cation
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.3110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.3110
Breast Cancer
[description not available]		02.2510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.2510
Cancer of Lung
[description not available]		02.2510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.2510
Aspergillus Infection
[description not available]		02.1510
Candida Infection
[description not available]		02.1510
C gattii Infection
[description not available]		02.1510
Fungal Diseases
[description not available]		02.1510
Aspergillosis
Infections with fungi of the genus ASPERGILLUS.		02.1510
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)		02.1510
Cryptococcosis
Fungal infection caused by genus CRYPTOCOCCUS.		02.1510
Mycoses
Diseases caused by FUNGI.		02.1510