Compounds > nsc 297170
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nsc 297170

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Description

NSC 297170: RN given refers to cpd without isomeric designation; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100424
CHEMBL ID18268
SCHEMBL ID5014485
MeSH IDM0103369

Synonyms (16)

Synonym
nsc366211
nsc-366211
68266-24-0
phenol,3'-(1,2-diethyl-1,2-ethanediyl)bis-
nsc-297170
nsc297170
CHEMBL18268
3-[4-(3-hydroxyphenyl)hexan-3-yl]phenol
1,2-diethyl-1,2-bis(3'-hydroxyphenyl)ethane
nsc 297170
phenol, 3,3'-(1,2-diethyl-1,2-ethanediyl)bis-
SCHEMBL5014485
3,4-bis(3'-hydroxyphenyl)hexane
3,3'-(hexane-3,4-diyl)diphenol
DTXSID90987795
PD181164
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (83)

Assay IDTitleYearJournalArticle
AID134175Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 5 mg/kg1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID48653Percent change in body weight DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 18 mg for 7 days1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID125618Predominant components of vaginal smear at a compound concentration of 500 ug was determined using vaginal cornification test; leucocytes (1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID125619Predominant components of vaginal smear at a compound concentration of 50 ug was determined using vaginal cornification test; leucocytes (1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID49019Progression of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 2 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130769Estrogenic activity in uterotrophic test in mice at 2.7 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID127522Estrogenic activity in mouse uterotrophic assay at 0.8 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID125620Vaginal cornification test in mice at 5 ug; predominant cellular component leucocytes (diestrus)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48668Percent change in DMBA-induced hormone-dependent mammary carcinoma tumor area at 1 mg after 28 days1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID49005Percent unchanged tumor size of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 4 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130412Antiestrogenic activity in uterotrophic test in mice at 0 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48660Percent change in body weight DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 4 mg for 7 days1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID103528Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-7 M with 10e-7 M 17-beta-estradiol1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48656Percent change in body weight DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 2 mg for 7 days1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID125483Vaginal cornification test in mice at 0 ug; predominant cellular component leucocytes (diestrus)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130749Estrogenic activity in uterotrophic test in mice at 800 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID126572Anti-estrogenic activity in mouse uterotrophic assay at 2.5 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID135382Inhibitory activity in mouse uterine weight test at 5 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48693Final number of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 1 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID103526Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-6 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID103532Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-7 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48857Partial remission of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 1 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130426Antiestrogenic activity in uterotrophic test in mice at 25 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48834Initial tumor number of DMBA-induced hormone-dependent mammary carcinoma in rats at 2 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID69388Displacement of [3H]estradiol from rat estrogen receptor1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130742Estrogenic activity in uterotrophic test in mice at 24 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID101932Inhibition of estrogen receptor positive MCF-7 cell proliferation as percent treated/control cell number after 10 days at 10e-7 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48838Initial tumor number of DMBA-induced hormone-dependent mammary carcinoma in rats at 4 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID71124Relative binding affinity for calf uterine estrogen receptor is the ratio of molar concentrations of 17-beta-estradiol and compound required to decrease amount of bound [3H]-E2 by 50% X 100.1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID48846Complete remission of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 2 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID49020Progression of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 4 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID125486Vaginal cornification test in mice at 2.5 ug; predominant cellular component leucocytes (diestrus)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48673Percent change in DMBA-induced hormone-dependent mammary carcinoma tumor area at 4 mg after 28 days1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130748Estrogenic activity in uterotrophic test in mice at 80 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID103535Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-8 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48845Complete remission of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 1 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID49023Progression of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 1 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID101939Inhibition of estrogen receptor positive MCF-7 cell proliferation as percent treated/control cell number after 10 days at 10e-9 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID71144Association constant for Estrogen receptor1980Journal of medicinal chemistry, Aug, Volume: 23, Issue:8
Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2 -diphenylethanes.
AID101931Inhibition of estrogen receptor positive MCF-7 cell proliferation as percent treated/control cell number after 10 days at 10e-6 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130413Antiestrogenic activity in uterotrophic test in mice at 0 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID135378Inhibitory activity in mouse uterine weight test at 25 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID125615Vaginal cornification test in mice at 25 ug; predominant cellular component leucocytes (diestrus)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID127533Estrogenic activity in mouse uterotrophic assay at 8 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID71146Relative binding affinity for Estrogen receptor compared to 17-beta-estradiol1980Journal of medicinal chemistry, Aug, Volume: 23, Issue:8
Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2 -diphenylethanes.
AID130747Estrogenic activity in uterotrophic test in mice at 8 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130735Estrogenic activity in uterotrophic test in mice at 0 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID126567Anti-estrogenic activity in mouse uterotrophic assay at 0 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID228855Estrogenic activity as uterotrophic effect in mice at 800 ug dose1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID135388Inhibitory activity in mouse uterine weight test at 500 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID126577Anti-estrogenic activity in mouse uterotrophic assay at 50 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID103533Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-7 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID127402Estrogenic activity in mouse uterotrophic assay at 0 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID127534Estrogenic activity in mouse uterotrophic assay at 80 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID130423Antiestrogenic activity in uterotrophic test in mice at 2.5 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48682Final number of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 1 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48859Partial remission of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 4 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130600Estrogenic activity in uterotrophic test in mice at 0.8 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID101938Inhibition of estrogen receptor positive MCF-7 cell proliferation as percent treated/control cell number after 10 days at 10e-8 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID101934Inhibition of estrogen receptor positive MCF-7 cell proliferation as percent treated/control cell number after 10 days at 10e-7 M and 10e-8 M 17-beta-estradiol1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID126573Anti-estrogenic activity in mouse uterotrophic assay at 25 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID48849Complete remission of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 4 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130429Antiestrogenic activity in uterotrophic test in mice at 5 ug (experiment 1)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48687Final number of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 4 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID135385Inhibitory activity in mouse uterine weight test at 50 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID230350Ratio of association constants for estradiol and compound in estrogen receptor binding assay1980Journal of medicinal chemistry, Aug, Volume: 23, Issue:8
Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2 -diphenylethanes.
AID127529Estrogenic activity in mouse uterotrophic assay at 24 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID101933Inhibition of estrogen receptor positive MCF-7 cell proliferation as percent treated/control cell number after 10 days at 10e-7 M with 10e-7 M 17-beta-estradiol1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID103529Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-7 M and 10e-8 M 17-beta-estradiol1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID134172Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 25 mg/kg1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID126578Anti-estrogenic activity in mouse uterotrophic assay at 500 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID134173Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 500 mg/kg1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID130553Antiestrogenic activity in uterotrophic test in mice at 500 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID130432Antiestrogenic activity in uterotrophic test in mice at 50 ug (experiment 2)1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48874Percent unchanged tumor size of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 2 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48873Percent unchanged tumor size of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 1 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID126576Anti-estrogenic activity in mouse uterotrophic assay at 5 ug1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID134168Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 2.5 mg/kg1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
AID48858Partial remission of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 2 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48671Percent change in DMBA-induced hormone-dependent mammary carcinoma tumor area at 2 mg after 28 days1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID48683Final number of DMBA-induced hormone-dependent mammary carcinoma tumors in rats at 2 mg1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID103536Inhibition of estrogen receptor positive MCF-7 cell proliferation as cell number after 10 days at 10e-9 M1981Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes.
AID134174Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 50 mg/kg1984Journal of medicinal chemistry, May, Volume: 27, Issue:5
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hexestrol
[no description available]		3.3570stilbenoid
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		1.961017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		2.6530ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane
[no description available]		2.6530
diethylstilbestrol
Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed). diethylstilbestrol : An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.		1.9610olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
tamoxifen
[no description available]		2.6530stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Mammary Neoplasms
[description not available]		03.2160
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		01.9610
Breast Cancer
[description not available]		02.3620
Hormone-Dependent Neoplasms
[description not available]		02.3620
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.3620